SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  88
GLU A 141
ALA A 144
LEU A  91
 None
 1.04A 1eta1-3e59A:
undetectable		 1eta1-3e59A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 5 LEU A  88
GLU A 141
ALA A 144
LEU A  91
 None
 1.06A 1eta2-3e59A:
undetectable		 1eta2-3e59A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  88
GLU A 141
ALA A 144
LEU A  91
 None
 1.07A 1etb1-3e59A:
undetectable		 1etb1-3e59A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  94
ILE A 108
ARG A  22
GLY A 265
 None
 0.87A 2du8A-3e59A:
undetectable		 2du8A-3e59A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 6 LEU A  94
ILE A 108
ARG A  22
GLY A 265
 None
 0.93A 2du8B-3e59A:
undetectable		 2du8B-3e59A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 6 PRO A 258
HIS A 255
ASP A 273
ASP A 274
 None
PO4  A 329 (-4.0A)
None
None
 1.25A 2lh8A-3e59A:
0.7		 2lh8A-3e59A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		3 / 3 PRO A 179
LEU A 180
GLN A 233
 None
 0.39A 3hznG-3e59A:
undetectable
3hznH-3e59A:
undetectable		 3hznG-3e59A:
20.73
3hznH-3e59A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 4 LEU A  17
LEU A  45
GLN A 257
GLU A  36
 None
None
PO4  A 329 (-3.7A)
None
 1.09A 4i41A-3e59A:
undetectable		 4i41A-3e59A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  63
ASP A 113
SER A 235
HIS A 255
 PO4  A 329 ( 4.9A)
None
PO4  A 329 ( 4.5A)
PO4  A 329 (-4.0A)
 1.14A 4k7gB-3e59A:
undetectable		 4k7gB-3e59A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 8 TRP A 279
SER A 112
TYR A 131
ILE A 128
 None
 1.29A 4ms4A-3e59A:
undetectable		 4ms4A-3e59A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 255
ILE A 254
SER A 235
ALA A  64
 PO4  A 329 (-4.0A)
None
PO4  A 329 ( 4.5A)
None
 1.27A 5msdA-3e59A:
undetectable		 5msdA-3e59A:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 106
GLY A 105
LEU A  94
PHE A  60
LEU A 252
 None
 1.19A 5w7pA-3e59A:
undetectable		 5w7pA-3e59A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 148
ALA A 144
THR A 109
VAL A  61
PHE A 246
 None
 1.34A 5x6yA-3e59A:
undetectable		 5x6yA-3e59A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 136
GLU A  84
VAL A  75
ARG A  22
 None
 1.16A 6fbvD-3e59A:
undetectable		 6fbvD-3e59A:
14.55