SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		5 / 10 ALA A  42
ASN A 118
ALA A 168
LEU A  83
ILE A 117
 None
 1.28A 1claA-3e5bA:
undetectable		 1claA-3e5bA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 5 ARG A 207
LEU A 305
ASP A 276
LEU A 218
 None
 1.14A 1n13B-3e5bA:
undetectable
1n13C-3e5bA:
undetectable		 1n13B-3e5bA:
15.00
1n13C-3e5bA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 8 GLU A 149
HIS A 199
GLU A 281
ASP A 101
 None
 1.20A 1s3zA-3e5bA:
undetectable
1s3zB-3e5bA:
undetectable		 1s3zA-3e5bA:
17.05
1s3zB-3e5bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 6 ASN A 118
ILE A  81
VAL A  74
ALA A 142
 None
 0.89A 2j5mA-3e5bA:
undetectable		 2j5mA-3e5bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		5 / 12 LEU A 203
ALA A 221
VAL A 220
PHE A 341
LEU A 332
 None
 1.28A 3b0wA-3e5bA:
undetectable		 3b0wA-3e5bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		5 / 12 LEU A 203
ALA A 221
VAL A 220
PHE A 341
LEU A 332
 None
 1.33A 3b0wB-3e5bA:
undetectable		 3b0wB-3e5bA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		3 / 3 TYR A 105
TYR A 165
GLY A  85
 None
 0.61A 3eteB-3e5bA:
undetectable
3eteD-3e5bA:
undetectable
3eteF-3e5bA:
undetectable		 3eteB-3e5bA:
23.14
3eteD-3e5bA:
23.14
3eteF-3e5bA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 8 GLY A 360
TYR A 369
ALA A 367
TYR A 361
 None
 0.81A 3u9hA-3e5bA:
undetectable		 3u9hA-3e5bA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 8 GLY A 360
TYR A 369
ALA A 367
TYR A 361
 None
 0.82A 3u9hB-3e5bA:
undetectable		 3u9hB-3e5bA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 8 GLY A 360
TYR A 369
ALA A 367
TYR A 361
 None
 0.79A 4bjcA-3e5bA:
undetectable		 4bjcA-3e5bA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 8 ASP A 177
ASP A 224
GLU A 226
TYR A 308
 None
 1.01A 4xjeA-3e5bA:
undetectable		 4xjeA-3e5bA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		3 / 3 HIS A 199
ASN A 202
ALA A 206
 None
 0.52A 5n4tB-3e5bA:
undetectable		 5n4tB-3e5bA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 4 ARG A 207
PHE A  16
ASP A  17
LEU A 306
 None
 1.44A 5uhdC-3e5bA:
0.0		 5uhdC-3e5bA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		3 / 3 LYS A  51
LEU A  52
ARG A  48
 None
 0.93A 5yw0A-3e5bA:
undetectable		 5yw0A-3e5bA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 4 ASP A 224
ILE A 194
PRO A 195
LEU A 193
 None
 1.11A 6mkeB-3e5bA:
undetectable		 6mkeB-3e5bA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3e5b ISOCITRATE LYASE
(Brucella
abortus) 		4 / 4 ASP A 224
ILE A 194
PRO A 195
LEU A 193
 None
 1.03A 6mkeA-3e5bA:
undetectable		 6mkeA-3e5bA:
12.40