SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A 149
VAL A 150
LEU A 152
MET A 188
 None
 0.98A 1fduB-3e5mA:
13.5		 1fduB-3e5mA:
24.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WM3_A_NFLA1300_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		7 / 11 CYH A 154
ASN A 158
HIS A 162
PHE A 163
TYR A 246
LEU A 257
TYR A 264
 None
 0.82A 2wm3A-3e5mA:
44.9		 2wm3A-3e5mA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WM3_A_NFLA1300_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		7 / 11 LEU A 114
CYH A 154
ASN A 158
HIS A 162
PHE A 163
LEU A 257
TYR A 264
 None
 0.67A 2wm3A-3e5mA:
44.9		 2wm3A-3e5mA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WM3_A_NFLA1300_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 114
HIS A 129
CYH A 154
ASN A 158
HIS A 162
 None
 1.48A 2wm3A-3e5mA:
44.9		 2wm3A-3e5mA:
99.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		6 / 6 LEU A 120
THR A 121
ARG A 151
PHE A 263
LEU A 266
ASP A 269
 None
 0.83A 2wm3A-3e5mA:
44.9		 2wm3A-3e5mA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLY A  17
GLY A  14
VAL A  78
VAL A 190
 None
 0.73A 4c5nC-3e5mA:
7.6		 4c5nC-3e5mA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 186
ARG A 218
ASP A 269
 None
 0.87A 4fp9D-3e5mA:
4.4		 4fp9D-3e5mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 186
ARG A 218
ASP A 269
 None
 0.81A 4fzvA-3e5mA:
4.4		 4fzvA-3e5mA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A 177
MET A 241
ASP A 170
 None
 0.89A 4mm4B-3e5mA:
undetectable		 4mm4B-3e5mA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A 113
LEU A 114
GLU A 115
ASP A 186
PHE A 130
 None
 1.26A 4wnuC-3e5mA:
undetectable		 4wnuC-3e5mA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A  72
TYR A  73
PRO A 146
 None
 0.67A 4zdyA-3e5mA:
undetectable		 4zdyA-3e5mA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLU A  26
GLY A 194
ARG A  22
GLY A  18
 None
 0.84A 5kprA-3e5mA:
undetectable		 5kprA-3e5mA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		4 / 7 THR A  79
PHE A 140
MET A 147
THR A  75
 None
 1.12A 5u6mA-3e5mA:
6.3		 5u6mA-3e5mA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3e5m NMRA-LIKE FAMILY
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 186
ARG A 218
ASP A 269
 None
 0.88A 5zvgB-3e5mA:
6.0		 5zvgB-3e5mA:
22.47