SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e5z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		4 / 8 SER A 131
VAL A 187
SER A 188
ASP A 221
 None
None
None
MG  A 297 (-2.9A)
 1.20A 1hwiB-3e5zA:
undetectable		 1hwiB-3e5zA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		4 / 6 ARG A   4
GLY A 250
ALA A   6
HIS A 240
 None
 0.99A 1wmqA-3e5zA:
undetectable		 1wmqA-3e5zA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		4 / 6 ARG A   4
GLY A 250
ALA A   6
HIS A 240
 None
 1.01A 1wpuB-3e5zA:
undetectable		 1wpuB-3e5zA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		3 / 3 SER A 104
HIS A  87
ASP A 138
 None
 0.84A 2oxtA-3e5zA:
undetectable		 2oxtA-3e5zA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		3 / 3 GLY A 176
ASP A 119
SER A 131
 None
 0.70A 2qhfA-3e5zA:
undetectable		 2qhfA-3e5zA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		5 / 12 GLY A 143
SER A 116
GLY A 146
ASN A  72
ASP A  46
 None
None
None
MG  A 297 ( 4.4A)
None
 1.34A 3r24A-3e5zA:
undetectable		 3r24A-3e5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		5 / 12 TYR A 135
GLY A 222
GLY A 176
LEU A 177
LYS A 219
 None
 1.17A 3vywD-3e5zA:
undetectable		 3vywD-3e5zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		5 / 11 LEU A 242
THR A 243
TRP A 232
ALA A 233
THR A 220
 None
 1.18A 4e0fA-3e5zA:
undetectable		 4e0fA-3e5zA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		4 / 5 THR A 274
THR A 258
THR A 190
ASN A  72
 None
None
None
MG  A 297 ( 4.4A)
 1.24A 4pgfB-3e5zA:
undetectable		 4pgfB-3e5zA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		4 / 7 GLY A  17
ALA A  18
GLU A  19
SER A 281
 None
 0.78A 4r1zB-3e5zA:
undetectable		 4r1zB-3e5zA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		5 / 12 GLU A 248
LEU A   3
ASP A 237
GLY A 238
LEU A 271
 None
 1.30A 5kc4E-3e5zA:
undetectable		 5kc4E-3e5zA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 3e5z PUTATIVE
GLUCONOLACTONASE
(Deinococcus
radiodurans) 		4 / 5 LEU A  89
TYR A 144
CYH A  85
ASP A 132
 None
 1.21A 5p9iA-3e5zA:
undetectable		 5p9iA-3e5zA:
21.89