SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e6a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		7 / 7 SER O 153
THR O 155
ASN O 157
CYH O 158
TYR O 316
ASN O 318
TYR O 322
 SO4  O6921 (-2.4A)
SO4  O6921 (-3.9A)
None
None
None
None
None
 0.46A 1dssG-3e6aO:
50.3		 1dssG-3e6aO:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		8 / 8 SER O 153
THR O 155
ASN O 157
CYH O 158
HIS O 181
TYR O 316
ASN O 318
TYR O 322
 SO4  O6921 (-2.4A)
SO4  O6921 (-3.9A)
None
None
None
None
None
None
 0.54A 1dssR-3e6aO:
50.0		 1dssR-3e6aO:
69.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 5 ILE O 183
ARG O 236
ASP O 317
ASN O 324
 None
SO4  O6920 (-3.7A)
None
None
 1.43A 1kiaD-3e6aO:
3.7		 1kiaD-3e6aO:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 7 THR O 184
GLU O 319
SER O 243
VAL O 245
 SO4  O6920 (-2.5A)
None
None
None
 1.20A 1tv8B-3e6aO:
undetectable		 1tv8B-3e6aO:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		3 / 3 LEU O 223
HIS O 167
LYS O 164
 None
 1.08A 1y7iA-3e6aO:
3.7		 1y7iA-3e6aO:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 5 ASP O 291
GLY O 274
VAL O 279
ILE O 296
 None
 0.94A 2aoiA-3e6aO:
undetectable		 2aoiA-3e6aO:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		3 / 3 GLY O 200
ASP O 197
SER O 194
 None
 0.59A 2qhfA-3e6aO:
undetectable		 2qhfA-3e6aO:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 7 TRP O 315
VAL O 313
CYH O 158
ILE O 296
 None
 1.23A 2xz5B-3e6aO:
undetectable
2xz5E-3e6aO:
undetectable		 2xz5B-3e6aO:
21.02
2xz5E-3e6aO:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 8 ILE O 296
TRP O 315
VAL O 313
CYH O 158
 None
 1.23A 2xz5A-3e6aO:
undetectable
2xz5C-3e6aO:
undetectable		 2xz5A-3e6aO:
21.02
2xz5C-3e6aO:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 8 ILE O 296
TRP O 315
VAL O 313
CYH O 158
 None
 1.25A 2xz5C-3e6aO:
undetectable
2xz5D-3e6aO:
undetectable		 2xz5C-3e6aO:
21.02
2xz5D-3e6aO:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 7 ILE O 296
TRP O 315
VAL O 313
CYH O 158
 None
 1.24A 2xz5D-3e6aO:
undetectable
2xz5E-3e6aO:
undetectable		 2xz5D-3e6aO:
21.02
2xz5E-3e6aO:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		8 / 8 SER O 153
THR O 155
ASN O 157
CYH O 158
HIS O 181
TYR O 316
ASN O 318
TYR O 322
 SO4  O6921 (-2.4A)
SO4  O6921 (-3.9A)
None
None
None
None
None
None
 0.49A 3dmtC-3e6aO:
47.9		 3dmtC-3e6aO:
55.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		3 / 3 GLU O 139
LEU O 329
ASP O 328
 None
 0.38A 3ko0A-3e6aO:
undetectable		 3ko0A-3e6aO:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		3 / 3 GLU O 139
LEU O 329
ASP O 328
 None
 0.41A 3ko0T-3e6aO:
undetectable		 3ko0T-3e6aO:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		5 / 12 ALA O 216
LEU O 312
PHE O 297
THR O 156
LEU O 159
 None
None
None
SO4  O6921 (-4.8A)
None
 1.05A 3mteB-3e6aO:
undetectable		 3mteB-3e6aO:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		5 / 12 ALA O 216
LEU O 312
PHE O 297
THR O 156
LEU O 159
 None
None
None
SO4  O6921 (-4.8A)
None
 1.05A 3p2kA-3e6aO:
3.2		 3p2kA-3e6aO:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 8 TRP O 315
VAL O 313
CYH O 158
ILE O 296
 None
 1.30A 4bqtC-3e6aO:
undetectable
4bqtD-3e6aO:
undetectable		 4bqtC-3e6aO:
21.02
4bqtD-3e6aO:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		5 / 12 TYR O 316
ASN O 227
GLY O 214
ALA O 215
GLY O 220
 None
None
SO4  O6921 (-4.1A)
SO4  O6921 (-2.9A)
None
 0.99A 4e1gA-3e6aO:
undetectable		 4e1gA-3e6aO:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		5 / 12 ALA O 112
ASP O 106
ILE O  87
GLY O 116
ASN O  83
 None
 0.96A 4obwB-3e6aO:
4.0		 4obwB-3e6aO:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		5 / 12 VAL O 121
GLY O 102
ILE O 123
SER O 124
HIS O 113
 None
 1.00A 4qdjA-3e6aO:
4.2		 4qdjA-3e6aO:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		3 / 3 THR O 156
ALA O 152
ASN O 157
 SO4  O6921 (-4.8A)
None
None
 0.62A 5ersA-3e6aO:
undetectable		 5ersA-3e6aO:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 6 PHE O 235
SER O 211
ARG O 236
GLY O 200
 None
None
SO4  O6920 (-3.7A)
None
 1.13A 5o4yF-3e6aO:
undetectable		 5o4yF-3e6aO:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3e6a GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
CYTOSOLIC
(Oryza
sativa) 		4 / 8 GLY O  15
ILE O  14
ASP O  50
HIS O  53
 None
 0.93A 6ag0A-3e6aO:
undetectable		 6ag0A-3e6aO:
14.33