SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 4 THR A 120
LEU A 119
LEU A 112
GLN A 109
 None
 1.14A 1fbmA-3e6eA:
undetectable		 1fbmA-3e6eA:
8.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_A_4AXA605_1
(ALANINE RACEMASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 8 LYS A  40
TYR A  44
ARG A 139
TYR A 356
 DCS  A 372 (-3.6A)
DCS  A 372 (-4.7A)
DCS  A 372 (-3.3A)
DCS  A 372 (-4.5A)
 0.64A 1xqlA-3e6eA:
49.3
1xqlB-3e6eA:
49.2		 1xqlA-3e6eA:
48.69
1xqlB-3e6eA:
48.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XQL_B_4AXB505_1
(ALANINE RACEMASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 8 LYS A  40
TYR A  44
ARG A 139
TYR A 356
 DCS  A 372 (-3.6A)
DCS  A 372 (-4.7A)
DCS  A 372 (-3.3A)
DCS  A 372 (-4.5A)
 0.63A 1xqlA-3e6eA:
49.3
1xqlB-3e6eA:
49.2		 1xqlA-3e6eA:
48.69
1xqlB-3e6eA:
48.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 9 GLY A 229
ALA A 226
LEU A 243
LEU A 211
HIS A 355
 None
 1.23A 1y7iA-3e6eA:
undetectable		 1y7iA-3e6eA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 6 LEU A 127
LEU A 116
LEU A 112
LEU A  91
 None
 0.99A 2ab2A-3e6eA:
undetectable		 2ab2A-3e6eA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 5 PRO A 126
ILE A  98
ARG A 128
ASP A 101
 None
 1.30A 2rhmB-3e6eA:
undetectable		 2rhmB-3e6eA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 VAL A 334
ARG A 248
GLY A  45
VAL A 358
 None
 0.82A 2y05A-3e6eA:
2.4
2y05B-3e6eA:
2.2		 2y05A-3e6eA:
22.53
2y05B-3e6eA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		3 / 3 TYR A 241
GLU A  25
ASN A 206
 None
None
DCS  A 372 ( 4.7A)
 0.96A 2y7hC-3e6eA:
undetectable		 2y7hC-3e6eA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 5 PRO A  82
THR A  19
VAL A  22
GLY A  58
 None
 1.14A 3elzA-3e6eA:
undetectable		 3elzA-3e6eA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 11 GLU A 164
HIS A 130
VAL A 106
ALA A 115
LEU A 127
 None
 1.17A 3mdzA-3e6eA:
undetectable		 3mdzA-3e6eA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 GLU A  50
SER A  51
VAL A  49
VAL A  39
 None
 1.31A 3n61A-3e6eA:
undetectable
3n61B-3e6eA:
undetectable		 3n61A-3e6eA:
21.19
3n61B-3e6eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		3 / 3 ASN A  21
ALA A  17
LYS A 244
 None
 0.97A 3runA-3e6eA:
undetectable		 3runA-3e6eA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 VAL A 325
ILE A 279
VAL A 299
VAL A 331
 None
 0.80A 3ufnB-3e6eA:
undetectable		 3ufnB-3e6eA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 ILE A  13
GLY A  43
ASN A  42
ILE A  18
ALA A  55
 None
 0.82A 3uwlB-3e6eA:
undetectable		 3uwlB-3e6eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 GLY A 186
THR A 178
PHE A 188
VAL A 216
ALA A 190
 None
 1.49A 4df3A-3e6eA:
undetectable		 4df3A-3e6eA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 8 LYS A 132
THR A 105
ALA A 107
VAL A  88
 DCS  A 372 ( 4.7A)
None
None
None
 0.88A 4iizB-3e6eA:
undetectable		 4iizB-3e6eA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 LEU A 119
GLN A 117
PHE A 161
LEU A 127
 None
 1.00A 5b3sC-3e6eA:
undetectable
5b3sJ-3e6eA:
undetectable		 5b3sC-3e6eA:
19.89
5b3sJ-3e6eA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 LEU A 119
GLN A 117
PHE A 161
LEU A 127
 None
 1.00A 5b3sP-3e6eA:
undetectable		 5b3sP-3e6eA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 CYH A 360
LEU A  67
ILE A 354
TYR A 228
TYR A 356
 None
None
None
None
DCS  A 372 (-4.5A)
 1.48A 5fepA-3e6eA:
3.9		 5fepA-3e6eA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 CYH A 360
LEU A  67
ILE A 354
TYR A 228
TYR A 356
 None
None
None
None
DCS  A 372 (-4.5A)
 1.49A 5fesA-3e6eA:
7.1		 5fesA-3e6eA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 10 GLY A 218
THR A  33
PHE A 170
ASN A 206
LEU A  29
 None
None
None
DCS  A 372 ( 4.7A)
None
 1.21A 5fhzC-3e6eA:
undetectable		 5fhzC-3e6eA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 4 GLN A 109
ALA A 151
GLN A 150
THR A 148
 None
 1.47A 5hhjB-3e6eA:
undetectable		 5hhjB-3e6eA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		4 / 7 ARG A 248
GLU A 369
THR A   9
PRO A 367
 None
 1.34A 6a4iB-3e6eA:
undetectable		 6a4iB-3e6eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		3 / 3 GLN A 156
TRP A 163
VAL A 129
 None
 1.03A 6auuA-3e6eA:
undetectable		 6auuA-3e6eA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 GLY A 234
ILE A 284
PHE A 362
GLY A 289
LEU A 351
 None
 1.15A 6e8qA-3e6eA:
undetectable		 6e8qA-3e6eA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		3 / 3 LEU A 247
GLY A 335
PHE A 297
 None
 0.61A 6exiC-3e6eA:
2.5		 6exiC-3e6eA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		3 / 3 THR A  15
ALA A  54
LYS A  56
 None
 0.67A 6fgcA-3e6eA:
undetectable		 6fgcA-3e6eA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		3 / 3 THR A  15
ALA A  54
LYS A  56
 None
 0.71A 6fgdA-3e6eA:
undetectable		 6fgdA-3e6eA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 ILE A  13
GLY A  43
ASN A  42
ILE A  18
ALA A  55
 None
 0.81A 6qxsD-3e6eA:
undetectable		 6qxsD-3e6eA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 3e6e ALANINE RACEMASE
(Enterococcus
faecalis) 		5 / 12 ILE A  13
GLY A  43
ASN A  42
ILE A  18
ALA A  55
 None
 0.81A 6qyaD-3e6eA:
undetectable		 6qyaD-3e6eA:
22.75