SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e73'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 199
GLY A 190
ILE A 224
TYR A 225
 None
 0.76A 11gsB-3e73A:
2.7		 11gsB-3e73A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  71
LEU A 372
GLY A  67
ALA A  88
LEU A  87
 None
 1.16A 1gs4A-3e73A:
undetectable		 1gs4A-3e73A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 ARG A 155
LEU A 228
GLY A 154
GLY A 157
ILE A 224
 None
 1.09A 1p91B-3e73A:
undetectable		 1p91B-3e73A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 9 PHE A 164
VAL A 119
PHE A 106
SER A  95
LEU A  73
 None
 1.30A 1wrkA-3e73A:
undetectable
1wrkB-3e73A:
undetectable		 1wrkA-3e73A:
11.41
1wrkB-3e73A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 327
TYR A 319
ASN A 328
ALA A 329
ALA A 348
 None
 1.18A 2bm9C-3e73A:
undetectable		 2bm9C-3e73A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		4 / 4 GLY A  67
GLY A  64
GLY A  59
GLY A  61
 None
 0.67A 3bogC-3e73A:
undetectable		 3bogC-3e73A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 373
GLY A  67
GLY A  64
SER A 371
HIS A  74
 None
 1.29A 3dlcA-3e73A:
undetectable		 3dlcA-3e73A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		4 / 7 GLY A 216
GLY A 278
GLU A 150
ALA A 222
 None
 0.66A 3fpjB-3e73A:
undetectable		 3fpjB-3e73A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 172
LEU A 137
ILE A 134
LEU A 399
TYR A 227
 None
 1.45A 3gwxB-3e73A:
undetectable		 3gwxB-3e73A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A 321
TRP A 275
GLY A 281
 None
 0.79A 3l35A-3e73A:
undetectable
3l35H-3e73A:
undetectable		 3l35A-3e73A:
10.40
3l35H-3e73A:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A 321
TRP A 275
GLY A 281
 None
 0.79A 3l35B-3e73A:
undetectable
3l35K-3e73A:
undetectable		 3l35B-3e73A:
10.40
3l35K-3e73A:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL A  70
LEU A  51
GLY A  67
GLY A  64
TRP A  65
 None
 1.20A 3ls4H-3e73A:
undetectable		 3ls4H-3e73A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 153
CYH A 276
CYH A 322
TYR A  62
 None
ZN  A 501 (-2.1A)
ZN  A 501 ( 2.1A)
None
 1.45A 3pmzE-3e73A:
undetectable		 3pmzE-3e73A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		4 / 5 TYR A 158
THR A 105
PHE A 106
LEU A 114
 None
 1.39A 3qelC-3e73A:
undetectable		 3qelC-3e73A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA213_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 373
VAL A 116
PHE A 164
TYR A 160
PHE A 106
 None
 1.36A 3r6wA-3e73A:
undetectable
3r6wB-3e73A:
undetectable		 3r6wA-3e73A:
19.56
3r6wB-3e73A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 10 VAL A 116
PHE A 164
TYR A 160
PHE A 106
PHE A 373
 None
 1.32A 3r6wA-3e73A:
undetectable
3r6wB-3e73A:
undetectable		 3r6wA-3e73A:
19.56
3r6wB-3e73A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 375
GLY A 320
ILE A 380
SER A 371
LEU A  51
 None
 1.12A 4mwzA-3e73A:
undetectable		 4mwzA-3e73A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		4 / 7 ILE A 104
ILE A 159
THR A 185
ILE A 186
 None
 0.79A 5fukA-3e73A:
undetectable
5fukB-3e73A:
undetectable		 5fukA-3e73A:
19.18
5fukB-3e73A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  28
LEU A 387
PHE A 382
LEU A 333
 None
 0.81A 5gs4A-3e73A:
undetectable		 5gs4A-3e73A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A  78
ASP A  77
LEU A 386
LEU A 333
THR A 334
 None
 1.17A 5hnwB-3e73A:
undetectable		 5hnwB-3e73A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A  78
ASP A  77
LEU A 386
LEU A 333
THR A 334
 None
 1.23A 5hnxB-3e73A:
undetectable		 5hnxB-3e73A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 107
GLY A 157
GLU A 398
LEU A 399
LEU A 163
 None
 1.05A 5nwvA-3e73A:
undetectable		 5nwvA-3e73A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 317
HIS A 274
HIS A 323
 GSH  A 502 (-2.7A)
GSH  A 502 (-4.0A)
ZN  A 501 ( 3.0A)
 1.29A 5oexA-3e73A:
undetectable		 5oexA-3e73A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 317
HIS A 274
HIS A 323
 GSH  A 502 (-2.7A)
GSH  A 502 (-4.0A)
ZN  A 501 ( 3.0A)
 1.30A 5oexB-3e73A:
undetectable		 5oexB-3e73A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 317
HIS A 274
HIS A 323
 GSH  A 502 (-2.7A)
GSH  A 502 (-4.0A)
ZN  A 501 ( 3.0A)
 1.28A 5oexC-3e73A:
undetectable		 5oexC-3e73A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 LYS A 317
HIS A 274
HIS A 323
 GSH  A 502 (-2.7A)
GSH  A 502 (-4.0A)
ZN  A 501 ( 3.0A)
 1.27A 5oexD-3e73A:
undetectable		 5oexD-3e73A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		3 / 3 GLY A 324
LEU A 315
HIS A 274
 None
None
GSH  A 502 (-4.0A)
 0.70A 5u63A-3e73A:
undetectable		 5u63A-3e73A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 3e73 LANC-LIKE PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 182
LEU A 140
ASN A 141
GLY A 157
LEU A 163
 None
 1.06A 6dwnC-3e73A:
undetectable		 6dwnC-3e73A:
12.15