SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e74'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 5 HIS A  59
HIS A 186
HIS A 242
ASP A 315
 FE  A 454 (-3.5A)
FE  A 455 (-3.2A)
FE  A 455 (-3.6A)
FE  A 454 (-2.8A)
 0.47A 1e9yB-3e74A:
23.2		 1e9yB-3e74A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 6 HIS A  59
HIS A  61
HIS A 186
HIS A 242
ASP A 315
 FE  A 454 (-3.5A)
FE  A 454 (-3.4A)
FE  A 455 (-3.2A)
FE  A 455 (-3.6A)
FE  A 454 (-2.8A)
 0.59A 1fweC-3e74A:
24.2		 1fweC-3e74A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 3e74 ALLANTOINASE
(Escherichia
coli) 		3 / 3 ALA A 208
HIS A 209
VAL A 212
 None
 0.41A 1lqtB-3e74A:
undetectable		 1lqtB-3e74A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 3e74 ALLANTOINASE
(Escherichia
coli) 		3 / 3 ALA A 208
HIS A 209
VAL A 212
 None
 0.41A 1lquB-3e74A:
undetectable		 1lquB-3e74A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 12 GLY A 125
GLY A 124
ASP A 163
ASP A 166
ARG A 226
 KCX  A 146 ( 3.4A)
None
None
None
None
 0.90A 1sqfA-3e74A:
undetectable		 1sqfA-3e74A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 8 ASP A  57
SER A 314
TYR A 406
HIS A 316
 None
 1.36A 2bteA-3e74A:
undetectable		 2bteA-3e74A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 8 ASP A  57
SER A 314
TYR A 406
HIS A 316
 None
 1.29A 2bteD-3e74A:
undetectable		 2bteD-3e74A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 10 ALA A 349
GLU A 348
ARG A 416
MET A  55
LEU A 363
 None
 1.44A 2ocfA-3e74A:
undetectable		 2ocfA-3e74A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 6 THR A  60
GLU A  90
LYS A 115
ILE A 118
 None
 1.31A 2w98B-3e74A:
undetectable		 2w98B-3e74A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 5 ARG A 428
ILE A 448
VAL A  56
THR A 425
 None
 1.23A 3eigA-3e74A:
undetectable		 3eigA-3e74A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 12 LEU A 134
VAL A 142
GLY A 141
LEU A 449
LEU A 176
 None
 1.05A 3ijdA-3e74A:
4.7		 3ijdA-3e74A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 7 GLY A 378
CYH A 341
GLY A 361
PHE A 360
 None
 0.99A 3ko0M-3e74A:
undetectable
3ko0P-3e74A:
undetectable		 3ko0M-3e74A:
11.70
3ko0P-3e74A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 7 ASP A  57
SER A 314
TYR A 406
HIS A 316
 None
 1.29A 4arcA-3e74A:
undetectable		 4arcA-3e74A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 7 TYR A 270
HIS A 269
ILE A 291
PRO A 289
 None
 1.13A 4g5jA-3e74A:
undetectable		 4g5jA-3e74A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 5 HIS A  59
HIS A 186
HIS A 242
ASP A 315
 FE  A 454 (-3.5A)
FE  A 455 (-3.2A)
FE  A 455 (-3.6A)
FE  A 454 (-2.8A)
 0.45A 4h9mA-3e74A:
25.0		 4h9mA-3e74A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 8 CYH A 241
LEU A 238
LEU A 228
VAL A 227
 KCX  A 146 ( 3.8A)
None
None
None
 0.90A 4oj4A-3e74A:
undetectable		 4oj4A-3e74A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 6 MET A 364
MET A 342
ILE A  30
ILE A  23
 None
 0.99A 4olmA-3e74A:
undetectable		 4olmA-3e74A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 5 GLY A  76
ARG A  78
GLU A 405
PHE A 439
 None
 1.24A 4r82A-3e74A:
undetectable
4r82B-3e74A:
undetectable		 4r82A-3e74A:
18.61
4r82B-3e74A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 12 ASP A 385
LEU A 427
LEU A  14
GLU A  15
GLY A  54
 None
 1.23A 4retA-3e74A:
undetectable		 4retA-3e74A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 12 ASP A 385
LEU A 427
LEU A  14
GLU A  15
GLY A  54
 None
 1.23A 4retC-3e74A:
undetectable		 4retC-3e74A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 6 HIS A  59
HIS A  61
HIS A 186
HIS A 242
ASP A 315
 FE  A 454 (-3.5A)
FE  A 454 (-3.4A)
FE  A 455 (-3.2A)
FE  A 455 (-3.6A)
FE  A 454 (-2.8A)
 0.46A 4ubpC-3e74A:
24.4		 4ubpC-3e74A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 8 ILE A 448
ALA A  58
VAL A  56
VAL A 143
 None
 0.90A 5ecnD-3e74A:
undetectable		 5ecnD-3e74A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		3 / 3 TRP A 301
ILE A 309
SER A 266
 None
 0.99A 5gqbA-3e74A:
4.4		 5gqbA-3e74A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 5 ASP A  57
HIS A  59
GLY A 337
ALA A 336
 None
FE  A 454 (-3.5A)
None
None
 0.95A 5hwaA-3e74A:
undetectable		 5hwaA-3e74A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 12 ILE A 418
ALA A 336
GLY A  76
THR A  75
TYR A 433
 None
 0.94A 5igiA-3e74A:
undetectable		 5igiA-3e74A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 12 THR A  77
THR A  75
GLY A  83
ALA A  81
THR A 425
 None
 1.40A 5lf3N-3e74A:
undetectable		 5lf3N-3e74A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 12 VAL A 431
GLY A 429
ALA A 386
PHE A 390
GLU A 436
 None
 1.08A 6bqgA-3e74A:
undetectable		 6bqgA-3e74A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 12 PHE A 109
LEU A  96
LEU A 449
VAL A 142
ASP A 101
 None
 1.25A 6bxmA-3e74A:
undetectable		 6bxmA-3e74A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 3e74 ALLANTOINASE
(Escherichia
coli) 		3 / 3 GLY A 429
ASP A 387
ILE A 380
 None
 0.57A 6dgxB-3e74A:
undetectable		 6dgxB-3e74A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 10 PHE A 388
GLY A  10
ILE A   7
ILE A  30
ILE A  33
 None
 1.06A 6ebpD-3e74A:
undetectable		 6ebpD-3e74A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 11 PHE A 388
GLY A  10
ILE A   7
ILE A  30
ILE A  33
 None
 1.07A 6ebzA-3e74A:
undetectable		 6ebzA-3e74A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 11 PHE A 388
GLY A  10
ILE A   7
ILE A  30
ILE A  33
 None
 1.06A 6ebzD-3e74A:
undetectable		 6ebzD-3e74A:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 3e74 ALLANTOINASE
(Escherichia
coli) 		4 / 6 ALA A  40
GLY A  28
ILE A 426
PHE A 390
 None
 0.82A 6f8cA-3e74A:
undetectable		 6f8cA-3e74A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3e74 ALLANTOINASE
(Escherichia
coli) 		5 / 11 PHE A 388
GLY A  10
ILE A   7
ILE A  30
ILE A  33
 None
 1.05A 6gp2A-3e74A:
undetectable		 6gp2A-3e74A:
10.99