SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e77'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.13A 1q23B-3e77A:
undetectable		 1q23B-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.14A 1q23C-3e77A:
undetectable		 1q23C-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 10 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.16A 1q23E-3e77A:
undetectable		 1q23E-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 11 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.09A 1q23F-3e77A:
1.9		 1q23F-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 11 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.14A 1q23I-3e77A:
undetectable		 1q23I-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 11 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.20A 1q23J-3e77A:
1.7		 1q23J-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 10 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.14A 1q23K-3e77A:
undetectable		 1q23K-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 11 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.17A 1q23L-3e77A:
undetectable		 1q23L-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 6 ILE A  73
VAL A 210
ILE A  91
ILE A 121
 None
 0.81A 1uwhB-3e77A:
undetectable		 1uwhB-3e77A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		3 / 3 VAL A 124
VAL A 103
TRP A 140
 None
 0.92A 1w5uA-3e77A:
undetectable
1w5uB-3e77A:
undetectable		 1w5uA-3e77A:
6.25
1w5uB-3e77A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 151
THR A 104
PRO A 166
VAL A 293
ILE A 134
 None
 1.19A 1z9hA-3e77A:
undetectable		 1z9hA-3e77A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 151
THR A 104
PRO A 166
VAL A 293
ILE A 134
 None
 1.18A 1z9hB-3e77A:
undetectable		 1z9hB-3e77A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 TYR A 151
THR A 104
PRO A 166
VAL A 293
ILE A 134
 None
 1.19A 1z9hC-3e77A:
undetectable		 1z9hC-3e77A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 GLY A 263
GLY A 262
ALA A 265
ALA A 266
 None
 0.61A 2ha4A-3e77A:
undetectable		 2ha4A-3e77A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 7 GLY A 263
GLY A 262
ALA A 265
ALA A 266
 None
 0.63A 2ha4B-3e77A:
undetectable		 2ha4B-3e77A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		3 / 3 VAL A 103
TRP A 140
VAL A 124
 None
 0.92A 2izqC-3e77A:
undetectable
2izqD-3e77A:
undetectable		 2izqC-3e77A:
6.25
2izqD-3e77A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 9 LEU A 332
ILE A 341
GLY A 340
GLY A 339
SER A 331
 None
 1.16A 2qmmA-3e77A:
undetectable		 2qmmA-3e77A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_A_PXLA1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 11 CYH A 152
THR A 156
ASP A 176
SER A 179
LYS A 200
 PLP  A 400 ( 3.9A)
PLP  A 400 (-2.9A)
PLP  A 400 (-2.9A)
PLP  A 400 (-3.3A)
PLP  A 400 (-1.4A)
 0.50A 2z9wA-3e77A:
34.1		 2z9wA-3e77A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z9W_B_PXLB1197_1
(ASPARTATE
AMINOTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 11 CYH A 152
THR A 156
ASP A 176
SER A 179
LYS A 200
 PLP  A 400 ( 3.9A)
PLP  A 400 (-2.9A)
PLP  A 400 (-2.9A)
PLP  A 400 (-3.3A)
PLP  A 400 (-1.4A)
 0.50A 2z9wB-3e77A:
34.1		 2z9wB-3e77A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 MET A 267
ALA A 264
GLY A 263
ILE A 258
 None
 0.82A 2zm9A-3e77A:
undetectable		 2zm9A-3e77A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		3 / 3 SER A 238
SER A 237
HIS A  44
 None
 0.69A 3mzeA-3e77A:
undetectable		 3mzeA-3e77A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.08A 3u9fB-3e77A:
undetectable
3u9fC-3e77A:
undetectable		 3u9fB-3e77A:
18.26
3u9fC-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 10 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.11A 3u9fE-3e77A:
undetectable		 3u9fE-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.11A 3u9fH-3e77A:
1.8
3u9fI-3e77A:
1.9		 3u9fH-3e77A:
18.26
3u9fI-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 10 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.11A 3u9fI-3e77A:
1.9		 3u9fI-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.09A 3u9fJ-3e77A:
undetectable
3u9fK-3e77A:
undetectable		 3u9fJ-3e77A:
18.26
3u9fK-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 10 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.06A 3u9fK-3e77A:
undetectable		 3u9fK-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 11 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.13A 3u9fN-3e77A:
undetectable
3u9fO-3e77A:
undetectable		 3u9fN-3e77A:
18.26
3u9fO-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 9 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.13A 3u9fP-3e77A:
undetectable		 3u9fP-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 10 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.10A 3u9fR-3e77A:
undetectable		 3u9fR-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 SER A 238
LEU A 255
VAL A 202
PHE A 181
VAL A  60
 None
 1.07A 3u9fP-3e77A:
undetectable
3u9fS-3e77A:
1.7		 3u9fP-3e77A:
18.26
3u9fS-3e77A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 PHE A 246
VAL A  39
ILE A  52
SER A 247
 None
 0.91A 4eyzA-3e77A:
undetectable		 4eyzA-3e77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 PHE A 246
VAL A  39
ILE A  52
SER A 247
 None
 0.92A 4eyzB-3e77A:
undetectable		 4eyzB-3e77A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 GLY A 203
VAL A 250
LEU A  17
PRO A  18
VAL A  21
 None
 0.74A 4gc9A-3e77A:
undetectable		 4gc9A-3e77A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 7 TYR A 150
VAL A 102
TRP A 140
ILE A 134
 None
 1.19A 4xo7B-3e77A:
undetectable		 4xo7B-3e77A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		5 / 12 ILE A 307
GLY A 340
PHE A 360
ALA A 324
ILE A 303
 None
 1.19A 5ih0A-3e77A:
undetectable		 5ih0A-3e77A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 ALA A 198
VAL A 202
LEU A 182
ILE A 211
 None
 0.78A 5nujA-3e77A:
undetectable		 5nujA-3e77A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		4 / 8 ALA A 198
VAL A 202
LEU A 182
VAL A  72
 None
 0.83A 5nujA-3e77A:
undetectable		 5nujA-3e77A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		3 / 3 GLU A 280
TYR A 279
ARG A 298
 None
 0.78A 5uunB-3e77A:
undetectable		 5uunB-3e77A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		3 / 3 ARG A 342
PHE A 364
LEU A 357
 None
 0.84A 5veuA-3e77A:
undetectable		 5veuA-3e77A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3e77 PHOSPHOSERINE
AMINOTRANSFERASE
(Homo
sapiens) 		3 / 3 ASN A 297
VAL A 338
HIS A 158
 None
 0.86A 6a5yD-3e77A:
undetectable		 6a5yD-3e77A:
11.11