SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1F86_B_T44B528_1 (TRANSTHYRETIN THR119MET VARIANT)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 4	LYS A 23 LEU A 254 ALA A 19 LEU A 16	None	1.21A	1f86B-3e7fA: undetectable	1f86B-3e7fA: 17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT6_A_RTLA184_0 (PLASMA RETINOL-BINDING PROTEIN)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	5 / 11	LEU A 157 ALA A 53 VAL A 155 MET A 90 LEU A 69	None	1.40A	1kt6A-3e7fA: undetectable	1kt6A-3e7fA: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KT7_A_RTLA184_0 (PLASMA RETINOL-BINDING PROTEIN)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	5 / 11	LEU A 157 ALA A 53 VAL A 155 MET A 90 LEU A 69	None	1.42A	1kt7A-3e7fA: undetectable	1kt7A-3e7fA: 22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V54_W_CHDW4060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE I CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.85A	1v54N-3e7fA: undetectable 1v54W-3e7fA: undetectable	1v54N-3e7fA: 19.65 1v54W-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V55_J_CHDJ3060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE I CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.82A	1v55A-3e7fA: undetectable 1v55J-3e7fA: undetectable	1v55A-3e7fA: 19.65 1v55J-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V55_W_CHDW4060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE I CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.83A	1v55N-3e7fA: undetectable 1v55W-3e7fA: undetectable	1v55N-3e7fA: 19.65 1v55W-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYR_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.83A	2dyrN-3e7fA: undetectable 2dyrW-3e7fA: undetectable	2dyrN-3e7fA: 19.65 2dyrW-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIJ_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.84A	2eijN-3e7fA: undetectable 2eijW-3e7fA: undetectable	2eijN-3e7fA: 19.65 2eijW-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIL_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.86A	2eilN-3e7fA: undetectable 2eilW-3e7fA: undetectable	2eilN-3e7fA: 19.65 2eilW-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIN_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.83A	2einA-3e7fA: undetectable 2einJ-3e7fA: undetectable	2einA-3e7fA: 19.65 2einJ-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_F_TACF3888_1 (ELONGATION FACTOR EF-TU)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	THR A 202 PRO A 205 SER A 173 LEU A 160	None	0.89A	2hdnE-3e7fA: undetectable 2hdnF-3e7fA: undetectable 2hdnH-3e7fA: undetectable	2hdnE-3e7fA: 10.37 2hdnF-3e7fA: 24.23 2hdnH-3e7fA: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_H_TACH4888_1 (ELONGATION FACTOR EF-TU)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	SER A 173 LEU A 160 THR A 202 PRO A 205	None	0.88A	2hdnF-3e7fA: undetectable 2hdnG-3e7fA: undetectable 2hdnH-3e7fA: undetectable	2hdnF-3e7fA: 24.23 2hdnG-3e7fA: 10.37 2hdnH-3e7fA: 24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PKK_A_2FAA501_2 (ADENOSINE KINASE)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 4	ALA A 218 VAL A 226 PHE A 253 THR A 166	None	1.49A	2pkkA-3e7fA: undetectable	2pkkA-3e7fA: 22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMM_A_SAMA301_0 (UPF0217 PROTEIN AF_1056)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	5 / 9	LEU A 255 ILE A 259 GLY A 220 SER A 8 LEU A 217	None	1.18A	2qmmA-3e7fA: undetectable	2qmmA-3e7fA: 22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABK_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.76A	3abkA-3e7fA: undetectable 3abkJ-3e7fA: undetectable	3abkA-3e7fA: 19.65 3abkJ-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_W_CHDW1060_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.84A	3abmN-3e7fA: undetectable 3abmW-3e7fA: undetectable	3abmN-3e7fA: 19.65 3abmW-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG3_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.76A	3ag3A-3e7fA: undetectable 3ag3J-3e7fA: undetectable	3ag3A-3e7fA: 19.65 3ag3J-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG3_W_CHDW1059_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.76A	3ag3N-3e7fA: undetectable 3ag3W-3e7fA: undetectable	3ag3N-3e7fA: 19.65 3ag3W-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ASN_W_CHDW1059_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.84A	3asnN-3e7fA: undetectable 3asnW-3e7fA: undetectable	3asnN-3e7fA: 19.65 3asnW-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ASO_W_CHDW1059_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.83A	3asoN-3e7fA: undetectable 3asoW-3e7fA: undetectable	3asoN-3e7fA: 19.65 3asoW-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_A_SVRA508_1 (PHOSPHOLIPASE A2)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 5	VAL A 126 PHE A 105 ARG A 125 ARG A 200	None None None 6PG A 843 (-2.7A)	1.40A	3bjwE-3e7fA: undetectable	3bjwE-3e7fA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BLV_A_SAMA1281_0 (RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	5 / 12	LEU A 95 LEU A 55 HIS A 56 ASP A 57 GLY A 20	None None ZN A 301 (-3.2A) None None	0.92A	4blvA-3e7fA: 2.9	4blvA-3e7fA: 23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA0_A_SHHA404_1 (HISTONE DEACETYLASE 8)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	5 / 12	GLY A 159 HIS A 165 ASP A 163 MET A 194 GLY A 164	6PG A 843 ( 4.4A) 6PG A 843 (-3.5A) None 6PG A 843 (-3.7A) None	1.14A	4qa0A-3e7fA: undetectable	4qa0A-3e7fA: 23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA2_A_SHHA404_1 (HISTONE DEACETYLASE 8)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	5 / 12	GLY A 159 HIS A 165 ASP A 163 MET A 194 GLY A 164	6PG A 843 ( 4.4A) 6PG A 843 (-3.5A) None 6PG A 843 (-3.7A) None	1.16A	4qa2A-3e7fA: 3.6	4qa2A-3e7fA: 23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QA2_B_SHHB404_1 (HISTONE DEACETYLASE 8)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	5 / 12	GLY A 159 HIS A 165 ASP A 163 MET A 194 GLY A 164	6PG A 843 ( 4.4A) 6PG A 843 (-3.5A) None 6PG A 843 (-3.7A) None	1.16A	4qa2B-3e7fA: undetectable	4qa2B-3e7fA: 23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TXN_A_URFA302_1 (URIDINE PHOSPHORYLASE)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	THR A 166 GLY A 164 ALA A 241 ILE A 230	None	0.77A	4txnA-3e7fA: undetectable	4txnA-3e7fA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TXN_B_URFB302_1 (URIDINE PHOSPHORYLASE)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	THR A 166 GLY A 164 ALA A 241 ILE A 230	None	0.79A	4txnB-3e7fA: undetectable	4txnB-3e7fA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TXN_C_URFC302_1 (URIDINE PHOSPHORYLASE)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	THR A 166 GLY A 164 ALA A 241 ILE A 230	None	0.84A	4txnC-3e7fA: undetectable	4txnC-3e7fA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TXN_D_URFD302_1 (URIDINE PHOSPHORYLASE)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	THR A 166 GLY A 164 ALA A 241 ILE A 230	None	0.81A	4txnD-3e7fA: undetectable	4txnD-3e7fA: 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B1A_J_CHDJ102_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.83A	5b1aA-3e7fA: undetectable 5b1aJ-3e7fA: undetectable	5b1aA-3e7fA: 19.65 5b1aJ-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B3S_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.84A	5b3sA-3e7fA: undetectable 5b3sJ-3e7fA: undetectable	5b3sA-3e7fA: 19.65 5b3sJ-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IY5_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.85A	5iy5A-3e7fA: undetectable 5iy5J-3e7fA: undetectable	5iy5A-3e7fA: 19.65 5iy5J-3e7fA: 13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L8D_B_ACTB601_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	3 / 3	THR A 113 PRO A 80 ASP A 82	None	0.78A	5l8dB-3e7fA: undetectable	5l8dB-3e7fA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MWU_B_ACTB601_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	3 / 3	THR A 113 PRO A 80 ASP A 82	None	0.78A	5mwuB-3e7fA: undetectable	5mwuB-3e7fA: 18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDQ_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.82A	5xdqN-3e7fA: undetectable 5xdqW-3e7fA: undetectable	5xdqN-3e7fA: 19.65 5xdqW-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XDX_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.82A	5xdxA-3e7fA: undetectable 5xdxJ-3e7fA: undetectable	5xdxA-3e7fA: 19.65 5xdxJ-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y7P_E_CHDE401_0 (BILE SALT HYDROLASE)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	LEU A 158 LEU A 217 ALA A 218 LEU A 255	None	0.60A	5y7pE-3e7fA: undetectable	5y7pE-3e7fA: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCP_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.85A	5zcpA-3e7fA: undetectable 5zcpJ-3e7fA: undetectable	5zcpA-3e7fA: 19.65 5zcpJ-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCP_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 8	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.85A	5zcpN-3e7fA: undetectable 5zcpW-3e7fA: undetectable	5zcpN-3e7fA: 19.65 5zcpW-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCQ_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.85A	5zcqA-3e7fA: undetectable 5zcqJ-3e7fA: undetectable	5zcqA-3e7fA: 19.65 5zcqJ-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6BKL_G_EU7G101_0 (MATRIX PROTEIN 2)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	5 / 9	ALA A 167 SER A 168 ALA A 43 GLY A 159 GLY A 45	None 6PG A 843 ( 4.8A) None 6PG A 843 ( 4.4A) 6PG A 843 ( 3.8A)	1.20A	6bklE-3e7fA: undetectable 6bklF-3e7fA: undetectable 6bklG-3e7fA: undetectable 6bklH-3e7fA: undetectable	6bklE-3e7fA: 6.84 6bklF-3e7fA: 6.84 6bklG-3e7fA: 6.84 6bklH-3e7fA: 6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMF_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 7	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.84A	6nmfA-3e7fA: undetectable 6nmfJ-3e7fA: undetectable	6nmfA-3e7fA: 19.65 6nmfJ-3e7fA: 12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NMP_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3e7f	6-PHOSPHOGLUCONOLACT ONASE (Trypanosoma brucei)	4 / 5	ILE A 230 LEU A 231 THR A 219 LEU A 255	None	0.93A	6nmpN-3e7fA: undetectable 6nmpW-3e7fA: undetectable	6nmpN-3e7fA: 19.65 6nmpW-3e7fA: 12.55

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1F86_B_T44B528_1","TRANSTHYRETIN THR119MET VARIANT","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"LYS A  23;LEU A 254;ALA A  19;LEU A  16","None","1.21A","1f86B-3e7fA:undetectable","1f86B-3e7fA:17.89"],["1KT6_A_RTLA184_0","PLASMA RETINOL-BINDING PROTEIN","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",5,"LEU A 157;ALA A  53;VAL A 155;MET A  90;LEU A  69","None","1.40A","1kt6A-3e7fA:undetectable","1kt6A-3e7fA:22.01"],["1KT7_A_RTLA184_0","PLASMA RETINOL-BINDING PROTEIN","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",5,"LEU A 157;ALA A  53;VAL A 155;MET A  90;LEU A  69","None","1.42A","1kt7A-3e7fA:undetectable","1kt7A-3e7fA:22.01"],["1V54_W_CHDW4060_0","CYTOCHROME C OXIDASE POLYPEPTIDE I;CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.85A","1v54N-3e7fA:undetectable;1v54W-3e7fA:undetectable","1v54N-3e7fA:19.65;1v54W-3e7fA:12.55"],["1V55_J_CHDJ3060_0","CYTOCHROME C OXIDASE POLYPEPTIDE I;CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.82A","1v55A-3e7fA:undetectable;1v55J-3e7fA:undetectable","1v55A-3e7fA:19.65;1v55J-3e7fA:12.55"],["1V55_W_CHDW4060_0","CYTOCHROME C OXIDASE POLYPEPTIDE I;CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.83A","1v55N-3e7fA:undetectable;1v55W-3e7fA:undetectable","1v55N-3e7fA:19.65;1v55W-3e7fA:12.55"],["2DYR_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.83A","2dyrN-3e7fA:undetectable;2dyrW-3e7fA:undetectable","2dyrN-3e7fA:19.65;2dyrW-3e7fA:12.55"],["2EIJ_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.84A","2eijN-3e7fA:undetectable;2eijW-3e7fA:undetectable","2eijN-3e7fA:19.65;2eijW-3e7fA:12.55"],["2EIL_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.86A","2eilN-3e7fA:undetectable;2eilW-3e7fA:undetectable","2eilN-3e7fA:19.65;2eilW-3e7fA:12.55"],["2EIN_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.83A","2einA-3e7fA:undetectable;2einJ-3e7fA:undetectable","2einA-3e7fA:19.65;2einJ-3e7fA:12.55"],["2HDN_F_TACF3888_1","ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"THR A 202;PRO A 205;SER A 173;LEU A 160","None","0.89A","2hdnE-3e7fA:undetectable;2hdnF-3e7fA:undetectable;2hdnH-3e7fA:undetectable","2hdnE-3e7fA:10.37;2hdnF-3e7fA:24.23;2hdnH-3e7fA:24.23"],["2HDN_H_TACH4888_1","ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU;ELONGATION FACTOR EF-TU","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"SER A 173;LEU A 160;THR A 202;PRO A 205","None","0.88A","2hdnF-3e7fA:undetectable;2hdnG-3e7fA:undetectable;2hdnH-3e7fA:undetectable","2hdnF-3e7fA:24.23;2hdnG-3e7fA:10.37;2hdnH-3e7fA:24.23"],["2PKK_A_2FAA501_2","ADENOSINE KINASE","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ALA A 218;VAL A 226;PHE A 253;THR A 166","None","1.49A","2pkkA-3e7fA:undetectable","2pkkA-3e7fA:22.54"],["2QMM_A_SAMA301_0","UPF0217 PROTEIN AF_1056","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",5,"LEU A 255;ILE A 259;GLY A 220;SER A   8;LEU A 217","None","1.18A","2qmmA-3e7fA:undetectable","2qmmA-3e7fA:22.10"],["3ABK_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.76A","3abkA-3e7fA:undetectable;3abkJ-3e7fA:undetectable","3abkA-3e7fA:19.65;3abkJ-3e7fA:12.55"],["3ABM_W_CHDW1060_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.84A","3abmN-3e7fA:undetectable;3abmW-3e7fA:undetectable","3abmN-3e7fA:19.65;3abmW-3e7fA:12.55"],["3AG3_J_CHDJ60_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.76A","3ag3A-3e7fA:undetectable;3ag3J-3e7fA:undetectable","3ag3A-3e7fA:19.65;3ag3J-3e7fA:12.55"],["3AG3_W_CHDW1059_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.76A","3ag3N-3e7fA:undetectable;3ag3W-3e7fA:undetectable","3ag3N-3e7fA:19.65;3ag3W-3e7fA:12.55"],["3ASN_W_CHDW1059_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.84A","3asnN-3e7fA:undetectable;3asnW-3e7fA:undetectable","3asnN-3e7fA:19.65;3asnW-3e7fA:12.55"],["3ASO_W_CHDW1059_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.83A","3asoN-3e7fA:undetectable;3asoW-3e7fA:undetectable","3asoN-3e7fA:19.65;3asoW-3e7fA:12.55"],["3BJW_A_SVRA508_1","PHOSPHOLIPASE A2;PHOSPHOLIPASE A2","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"VAL A 126;PHE A 105;ARG A 125;ARG A 200","None;None;None;6PG A 843 (-2.7A)","1.40A","3bjwE-3e7fA:undetectable","3bjwE-3e7fA:19.33"],["4BLV_A_SAMA1281_0","RIBOSOMAL RNA LARGE SUBUNIT METHYLTRANSFERASE J","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",5,"LEU A  95;LEU A  55;HIS A  56;ASP A  57;GLY A  20","None;None; ZN A 301 (-3.2A);None;None","0.92A","4blvA-3e7fA:2.9","4blvA-3e7fA:23.57"],["4QA0_A_SHHA404_1","HISTONE DEACETYLASE 8","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",5,"GLY A 159;HIS A 165;ASP A 163;MET A 194;GLY A 164","6PG A 843 ( 4.4A);6PG A 843 (-3.5A);None;6PG A 843 (-3.7A);None","1.14A","4qa0A-3e7fA:undetectable","4qa0A-3e7fA:23.40"],["4QA2_A_SHHA404_1","HISTONE DEACETYLASE 8","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",5,"GLY A 159;HIS A 165;ASP A 163;MET A 194;GLY A 164","6PG A 843 ( 4.4A);6PG A 843 (-3.5A);None;6PG A 843 (-3.7A);None","1.16A","4qa2A-3e7fA:3.6","4qa2A-3e7fA:23.40"],["4QA2_B_SHHB404_1","HISTONE DEACETYLASE 8","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",5,"GLY A 159;HIS A 165;ASP A 163;MET A 194;GLY A 164","6PG A 843 ( 4.4A);6PG A 843 (-3.5A);None;6PG A 843 (-3.7A);None","1.16A","4qa2B-3e7fA:undetectable","4qa2B-3e7fA:23.40"],["4TXN_A_URFA302_1","URIDINE PHOSPHORYLASE","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"THR A 166;GLY A 164;ALA A 241;ILE A 230","None","0.77A","4txnA-3e7fA:undetectable","4txnA-3e7fA:21.68"],["4TXN_B_URFB302_1","URIDINE PHOSPHORYLASE","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"THR A 166;GLY A 164;ALA A 241;ILE A 230","None","0.79A","4txnB-3e7fA:undetectable","4txnB-3e7fA:21.68"],["4TXN_C_URFC302_1","URIDINE PHOSPHORYLASE","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"THR A 166;GLY A 164;ALA A 241;ILE A 230","None","0.84A","4txnC-3e7fA:undetectable","4txnC-3e7fA:21.68"],["4TXN_D_URFD302_1","URIDINE PHOSPHORYLASE","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"THR A 166;GLY A 164;ALA A 241;ILE A 230","None","0.81A","4txnD-3e7fA:undetectable","4txnD-3e7fA:21.68"],["5B1A_J_CHDJ102_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.83A","5b1aA-3e7fA:undetectable;5b1aJ-3e7fA:undetectable","5b1aA-3e7fA:19.65;5b1aJ-3e7fA:12.55"],["5B3S_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.84A","5b3sA-3e7fA:undetectable;5b3sJ-3e7fA:undetectable","5b3sA-3e7fA:19.65;5b3sJ-3e7fA:12.55"],["5IY5_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.85A","5iy5A-3e7fA:undetectable;5iy5J-3e7fA:undetectable","5iy5A-3e7fA:19.65;5iy5J-3e7fA:13.62"],["5L8D_B_ACTB601_0","NICKEL-BINDING PERIPLASMIC PROTEIN","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",3,"THR A 113;PRO A  80;ASP A  82","None","0.78A","5l8dB-3e7fA:undetectable","5l8dB-3e7fA:18.97"],["5MWU_B_ACTB601_0","NICKEL-BINDING PERIPLASMIC PROTEIN","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",3,"THR A 113;PRO A  80;ASP A  82","None","0.78A","5mwuB-3e7fA:undetectable","5mwuB-3e7fA:18.97"],["5XDQ_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.82A","5xdqN-3e7fA:undetectable;5xdqW-3e7fA:undetectable","5xdqN-3e7fA:19.65;5xdqW-3e7fA:12.55"],["5XDX_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT VIIA-HEART","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.82A","5xdxA-3e7fA:undetectable;5xdxJ-3e7fA:undetectable","5xdxA-3e7fA:19.65;5xdxJ-3e7fA:12.55"],["5Y7P_E_CHDE401_0","BILE SALT HYDROLASE","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"LEU A 158;LEU A 217;ALA A 218;LEU A 255","None","0.60A","5y7pE-3e7fA:undetectable","5y7pE-3e7fA:21.92"],["5ZCP_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.85A","5zcpA-3e7fA:undetectable;5zcpJ-3e7fA:undetectable","5zcpA-3e7fA:19.65;5zcpJ-3e7fA:12.55"],["5ZCP_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.85A","5zcpN-3e7fA:undetectable;5zcpW-3e7fA:undetectable","5zcpN-3e7fA:19.65;5zcpW-3e7fA:12.55"],["5ZCQ_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.85A","5zcqA-3e7fA:undetectable;5zcqJ-3e7fA:undetectable","5zcqA-3e7fA:19.65;5zcqJ-3e7fA:12.55"],["6BKL_G_EU7G101_0","MATRIX PROTEIN 2","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",5,"ALA A 167;SER A 168;ALA A  43;GLY A 159;GLY A  45","None;6PG A 843 ( 4.8A);None;6PG A 843 ( 4.4A);6PG A 843 ( 3.8A)","1.20A","6bklE-3e7fA:undetectable;6bklF-3e7fA:undetectable;6bklG-3e7fA:undetectable;6bklH-3e7fA:undetectable","6bklE-3e7fA:6.84;6bklF-3e7fA:6.84;6bklG-3e7fA:6.84;6bklH-3e7fA:6.84"],["6NMF_J_CHDJ101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.84A","6nmfA-3e7fA:undetectable;6nmfJ-3e7fA:undetectable","6nmfA-3e7fA:19.65;6nmfJ-3e7fA:12.55"],["6NMP_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3e7f","6-PHOSPHOGLUCONOLACTONASE","Trypanosoma brucei",4,"ILE A 230;LEU A 231;THR A 219;LEU A 255","None","0.93A","6nmpN-3e7fA:undetectable;6nmpW-3e7fA:undetectable","6nmpN-3e7fA:19.65;6nmpW-3e7fA:12.55"]]