SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e7g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD8_0
(GRAMICIDIN A)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 VAL A 305
VAL A 308
TRP A 295
 None
 0.79A 1av2C-3e7gA:
undetectable
1av2D-3e7gA:
undetectable		 1av2C-3e7gA:
2.91
1av2D-3e7gA:
2.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF1_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.32A 1df1A-3e7gA:
19.1		 1df1A-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DF1_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.33A 1df1B-3e7gA:
59.9		 1df1B-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWX_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.31A 1dwxA-3e7gA:
58.0		 1dwxA-3e7gA:
87.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 PRO A 350
VAL A 352
TYR A 373
MET A 374
 AT2  A 906 (-4.5A)
AT2  A 906 ( 4.8A)
None
HEM  A 901 ( 4.6A)
 0.18A 1m8dA-3e7gA:
60.4		 1m8dA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 VAL A 352
TYR A 373
MET A 374
GLU A 377
 AT2  A 906 ( 4.8A)
None
HEM  A 901 ( 4.6A)
AT2  A 906 ( 2.7A)
 1.18A 1m8dA-3e7gA:
60.4		 1m8dA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.44A 1m8dA-3e7gA:
60.4		 1m8dA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 PRO A 350
VAL A 352
TYR A 373
MET A 374
 AT2  A 906 (-4.5A)
AT2  A 906 ( 4.8A)
None
HEM  A 901 ( 4.6A)
 0.19A 1m8dB-3e7gA:
60.2		 1m8dB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8D_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.44A 1m8dB-3e7gA:
60.2		 1m8dB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8E_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.23A 1m8eA-3e7gA:
58.5		 1m8eA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.15A 1m8eB-3e7gA:
58.4		 1m8eB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8H_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.42A 1m8hA-3e7gA:
59.8		 1m8hA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8H_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.43A 1m8hB-3e7gA:
59.5		 1m8hB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8I_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.49A 1m8iA-3e7gA:
59.9		 1m8iA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M8I_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.44A 1m8iB-3e7gA:
59.9		 1m8iB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 PRO A 350
VAL A 352
TYR A 373
MET A 374
 AT2  A 906 (-4.5A)
AT2  A 906 ( 4.8A)
None
HEM  A 901 ( 4.6A)
 0.31A 1m9jA-3e7gA:
55.2		 1m9jA-3e7gA:
60.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 VAL A 352
TYR A 373
MET A 374
GLU A 377
 AT2  A 906 ( 4.8A)
None
HEM  A 901 ( 4.6A)
AT2  A 906 ( 2.7A)
 1.25A 1m9jA-3e7gA:
55.2		 1m9jA-3e7gA:
60.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 PRO A 350
VAL A 352
TYR A 373
MET A 374
 AT2  A 906 (-4.5A)
AT2  A 906 ( 4.8A)
None
HEM  A 901 ( 4.6A)
 0.24A 1m9jB-3e7gA:
55.3		 1m9jB-3e7gA:
60.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 VAL A 352
TYR A 373
MET A 374
GLU A 377
 AT2  A 906 ( 4.8A)
None
HEM  A 901 ( 4.6A)
AT2  A 906 ( 2.7A)
 1.18A 1m9jB-3e7gA:
55.3		 1m9jB-3e7gA:
60.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9T_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.48A 1m9tA-3e7gA:
60.3		 1m9tA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M9T_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.49A 1m9tB-3e7gA:
60.0		 1m9tB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N2N_A_H4BA901_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.30A 1n2nA-3e7gA:
60.5		 1n2nA-3e7gA:
87.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N2N_B_H4BB1901_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.38A 1n2nB-3e7gA:
60.7		 1n2nB-3e7gA:
87.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NOD_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.34A 1nodA-3e7gA:
57.6		 1nodA-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.33A 1nodB-3e7gA:
57.6		 1nodB-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.25A 1om5A-3e7gA:
56.7
1om5B-3e7gA:
57.0		 1om5A-3e7gA:
65.57
1om5B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 GLN A 205
TRP A 372
ALA A 439
SER A 442
 None
HEM  A 901 ( 3.7A)
None
None
 0.76A 1p6kA-3e7gA:
57.0		 1p6kA-3e7gA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 GLY A 202
GLN A 205
TRP A 372
ALA A 439
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.20A 1p6kA-3e7gA:
57.0		 1p6kA-3e7gA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.14A 1p6kA-3e7gA:
57.0		 1p6kA-3e7gA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 0.94A 1p6kA-3e7gA:
57.0		 1p6kA-3e7gA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.16A 1p6kB-3e7gA:
57.3		 1p6kB-3e7gA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.00A 1p6kB-3e7gA:
57.3		 1p6kB-3e7gA:
65.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.39A 1qomA-3e7gA:
58.3		 1qomA-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QOM_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.60A 1qomB-3e7gA:
58.1		 1qomB-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QW4_A_H4BA901_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.35A 1qw4A-3e7gA:
60.5		 1qw4A-3e7gA:
87.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QW4_B_H4BB903_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.29A 1qw4B-3e7gA:
60.5		 1qw4B-3e7gA:
87.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QW5_A_H4BA901_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.36A 1qw5A-3e7gA:
60.5		 1qw5A-3e7gA:
87.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QW5_B_H4BB903_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.29A 1qw5B-3e7gA:
60.4		 1qw5B-3e7gA:
87.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R35_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.72A 1r35A-3e7gA:
58.9		 1r35A-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R35_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.70A 1r35B-3e7gA:
58.9		 1r35B-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.09A 1rs6A-3e7gA:
56.7		 1rs6A-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 0.99A 1rs6A-3e7gA:
56.7		 1rs6A-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.19A 1rs6A-3e7gA:
56.7
1rs6B-3e7gA:
57.0		 1rs6A-3e7gA:
65.57
1rs6B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.11A 1rs6B-3e7gA:
57.0		 1rs6B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.03A 1rs6B-3e7gA:
57.0		 1rs6B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 GLY A 202
ILE A 204
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.66A 1rs7A-3e7gA:
57.0		 1rs7A-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 GLY A 202
ILE A 204
GLN A 205
TRP A 372
 HEM  A 901 ( 3.8A)
None
None
HEM  A 901 ( 3.7A)
 0.26A 1rs7B-3e7gA:
57.1		 1rs7B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 ILE A 204
GLN A 205
TRP A 372
SER A 442
 None
None
HEM  A 901 ( 3.7A)
None
 0.80A 1rs7B-3e7gA:
57.1		 1rs7B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.15A 1rs7B-3e7gA:
57.1		 1rs7B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.09A 1rs7B-3e7gA:
57.1		 1rs7B-3e7gA:
65.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VAF_A_H4BA901_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.47A 1vafA-3e7gA:
22.7		 1vafA-3e7gA:
87.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VAF_B_H4BB1901_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.37A 1vafB-3e7gA:
59.7		 1vafB-3e7gA:
87.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 VAL A 305
VAL A 308
TRP A 295
 None
 0.83A 1w5uC-3e7gA:
undetectable
1w5uD-3e7gA:
undetectable		 1w5uC-3e7gA:
2.91
1w5uD-3e7gA:
2.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.10A 1zzqA-3e7gA:
57.2		 1zzqA-3e7gA:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 0.97A 1zzqA-3e7gA:
57.2		 1zzqA-3e7gA:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 GLY A 202
GLN A 205
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.20A 1zzqB-3e7gA:
57.4		 1zzqB-3e7gA:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.15A 1zzqB-3e7gA:
57.4		 1zzqB-3e7gA:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.03A 1zzqB-3e7gA:
57.4		 1zzqB-3e7gA:
65.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 GLY A 202
GLN A 205
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.24A 1zzuA-3e7gA:
57.3		 1zzuA-3e7gA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.03A 1zzuA-3e7gA:
57.3		 1zzuA-3e7gA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 0.92A 1zzuA-3e7gA:
57.3		 1zzuA-3e7gA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 SER A 242
ASN A 208
ASN A 370
TRP A 194
 HEM  A 901 (-3.2A)
None
None
HEM  A 901 (-3.3A)
 1.33A 1zzuA-3e7gA:
57.3		 1zzuA-3e7gA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.17A 1zzuB-3e7gA:
57.6		 1zzuB-3e7gA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.00A 1zzuB-3e7gA:
57.6		 1zzuB-3e7gA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.17A 2g6hA-3e7gA:
56.8
2g6hB-3e7gA:
57.0		 2g6hA-3e7gA:
65.56
2g6hB-3e7gA:
65.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 VAL A 308
TRP A 295
VAL A 305
 None
 0.90A 2izqA-3e7gA:
undetectable
2izqB-3e7gA:
undetectable		 2izqA-3e7gA:
2.91
2izqB-3e7gA:
2.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NOD_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.32A 2nodA-3e7gA:
57.9		 2nodA-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.35A 2nodB-3e7gA:
57.9		 2nodB-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.26A 2nsiA-3e7gA:
61.3
2nsiB-3e7gA:
61.3		 2nsiA-3e7gA:
100.00
2nsiB-3e7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.25A 2nsiA-3e7gA:
61.3
2nsiB-3e7gA:
61.3		 2nsiA-3e7gA:
100.00
2nsiB-3e7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.28A 2nsiC-3e7gA:
61.3
2nsiD-3e7gA:
61.3		 2nsiC-3e7gA:
100.00
2nsiD-3e7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.26A 2nsiC-3e7gA:
61.3
2nsiD-3e7gA:
61.3		 2nsiC-3e7gA:
100.00
2nsiD-3e7gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 12 GLY A 202
GLY A 375
THR A 376
VAL A 422
ILE A 433
 HEM  A 901 ( 3.8A)
None
None
None
None
 1.24A 2wa2A-3e7gA:
undetectable		 2wa2A-3e7gA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 TYR A 233
ALA A 214
THR A 190
LEU A 209
 None
None
None
HEM  A 901 ( 4.9A)
 0.94A 2wx2B-3e7gA:
undetectable		 2wx2B-3e7gA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y37_A_H4BA1502_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.36A 2y37A-3e7gA:
60.1		 2y37A-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y37_B_H4BB1501_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.37A 2y37B-3e7gA:
60.2		 2y37B-3e7gA:
87.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 12 ALA A 189
PRO A 141
PHE A 146
GLY A 361
GLU A 358
 None
 1.08A 2zifA-3e7gA:
undetectable		 2zifA-3e7gA:
22.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.25A 3b3pA-3e7gA:
57.0
3b3pB-3e7gA:
57.1		 3b3pA-3e7gA:
65.64
3b3pB-3e7gA:
65.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 11 LEU A 309
ALA A 353
ALA A 351
HIS A 230
PHE A 247
 None
 1.39A 3bszF-3e7gA:
undetectable		 3bszF-3e7gA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 12 VAL A 422
GLU A 377
VAL A 475
ILE A 201
THR A 473
 None
AT2  A 906 ( 2.7A)
None
None
None
 1.19A 3dl9A-3e7gA:
undetectable		 3dl9A-3e7gA:
23.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DWJ_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.38A 3dwjA-3e7gA:
58.4		 3dwjA-3e7gA:
87.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DWJ_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.40A 3dwjB-3e7gA:
22.2		 3dwjB-3e7gA:
87.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 LEU A 125
ASP A 460
SER A 124
THR A 109
 None
 1.33A 3dzgB-3e7gA:
undetectable		 3dzgB-3e7gA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E65_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.40A 3e65A-3e7gA:
60.8		 3e65A-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E65_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.37A 3e65B-3e7gA:
60.8		 3e65B-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E67_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.50A 3e67A-3e7gA:
60.2		 3e67A-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E67_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.48A 3e67B-3e7gA:
59.9		 3e67B-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.14A 3e68A-3e7gA:
58.7		 3e68A-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E68_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.33A 3e68B-3e7gA:
58.7		 3e68B-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E6L_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.42A 3e6lA-3e7gA:
60.4		 3e6lA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E6L_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.51A 3e6lB-3e7gA:
60.0		 3e6lB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E6N_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 5 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.44A 3e6nA-3e7gA:
59.9		 3e6nA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E6N_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.23A 3e6nB-3e7gA:
60.1		 3e6nB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E6O_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.26A 3e6oA-3e7gA:
58.5		 3e6oA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E6O_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.21A 3e6oB-3e7gA:
58.6		 3e6oB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E6T_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.24A 3e6tA-3e7gA:
58.8		 3e6tA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.13A 3e6tB-3e7gA:
58.9		 3e6tB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E7I_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.51A 3e7iA-3e7gA:
57.8		 3e7iA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.34A 3e7iB-3e7gA:
59.1		 3e7iB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E7M_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.28A 3e7mA-3e7gA:
61.0		 3e7mA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E7M_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.49A 3e7mB-3e7gA:
60.8		 3e7mB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EAI_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.23A 3eaiA-3e7gA:
60.7		 3eaiA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EAI_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.36A 3eaiB-3e7gA:
60.5		 3eaiB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EBD_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.39A 3ebdA-3e7gA:
60.5		 3ebdA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EBD_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.39A 3ebdB-3e7gA:
60.3		 3ebdB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EBF_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.20A 3ebfA-3e7gA:
60.7		 3ebfA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EBF_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.34A 3ebfB-3e7gA:
60.5		 3ebfB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EJ8_A_H4BA1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.30A 3ej8A-3e7gA:
61.3
3ej8B-3e7gA:
61.4		 3ej8A-3e7gA:
99.53
3ej8B-3e7gA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EJ8_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.35A 3ej8A-3e7gA:
61.3
3ej8B-3e7gA:
61.4		 3ej8A-3e7gA:
99.53
3ej8B-3e7gA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EJ8_C_H4BC3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.43A 3ej8C-3e7gA:
60.8
3ej8D-3e7gA:
61.5		 3ej8C-3e7gA:
99.53
3ej8D-3e7gA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3EJ8_D_H4BD4902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.27A 3ej8C-3e7gA:
60.8
3ej8D-3e7gA:
61.5		 3ej8C-3e7gA:
99.53
3ej8D-3e7gA:
99.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 SER A 118
MET A 120
ARG A 381
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 ( 3.6A)
 0.48A 3jx1A-3e7gA:
57.1
3jx1B-3e7gA:
57.4		 3jx1A-3e7gA:
65.40
3jx1B-3e7gA:
65.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 VAL A 305
VAL A 308
TRP A 295
 None
 0.84A 3l8lA-3e7gA:
undetectable
3l8lB-3e7gA:
undetectable		 3l8lA-3e7gA:
2.91
3l8lB-3e7gA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 VAL A 305
VAL A 308
TRP A 295
 None
 0.84A 3l8lC-3e7gA:
undetectable
3l8lD-3e7gA:
undetectable		 3l8lC-3e7gA:
2.91
3l8lD-3e7gA:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 HIS A 230
LEU A 327
SER A 234
ASN A 236
 None
 0.82A 3lm8B-3e7gA:
undetectable
3lm8D-3e7gA:
undetectable		 3lm8B-3e7gA:
18.34
3lm8D-3e7gA:
18.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.01A 3n62A-3e7gA:
57.1		 3n62A-3e7gA:
65.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.03A 3n62A-3e7gA:
57.1		 3n62A-3e7gA:
65.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.04A 3n62B-3e7gA:
57.4		 3n62B-3e7gA:
65.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.04A 3n62B-3e7gA:
57.4		 3n62B-3e7gA:
65.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.04A 3n66B-3e7gA:
57.4		 3n66B-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.03A 3n66B-3e7gA:
57.4		 3n66B-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.26A 3nlqA-3e7gA:
56.8
3nlqB-3e7gA:
56.9		 3nlqA-3e7gA:
65.17
3nlqB-3e7gA:
65.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 SER A 118
MET A 120
ARG A 381
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 ( 3.6A)
 0.47A 3nlyA-3e7gA:
57.1
3nlyB-3e7gA:
57.3		 3nlyA-3e7gA:
65.64
3nlyB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NOD_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.35A 3nodA-3e7gA:
57.7		 3nodA-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NQS_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.46A 3nqsA-3e7gA:
60.7		 3nqsA-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NQS_B_H4BB952_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.44A 3nqsB-3e7gA:
60.7		 3nqsB-3e7gA:
87.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.49A 3nw2A-3e7gA:
57.8		 3nw2A-3e7gA:
87.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.46A 3nw2B-3e7gA:
20.3		 3nw2B-3e7gA:
87.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 LEU A 289
PRO A 306
LEU A 293
LEU A 309
 None
 1.10A 3q1eA-3e7gA:
undetectable
3q1eC-3e7gA:
undetectable		 3q1eA-3e7gA:
13.74
3q1eC-3e7gA:
13.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 SER A 118
MET A 120
ARG A 381
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 ( 3.6A)
 0.47A 3rqlA-3e7gA:
57.3
3rqlB-3e7gA:
57.5		 3rqlA-3e7gA:
65.64
3rqlB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 SER A 118
MET A 120
ARG A 381
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 ( 3.6A)
 0.37A 4capA-3e7gA:
57.0
4capB-3e7gA:
57.2		 4capA-3e7gA:
65.64
4capB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.28A 4cwxA-3e7gA:
55.5
4cwxB-3e7gA:
17.1		 4cwxA-3e7gA:
58.03
4cwxB-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.29A 4cwyA-3e7gA:
55.5
4cwyB-3e7gA:
17.2		 4cwyA-3e7gA:
58.03
4cwyB-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.28A 4cwyA-3e7gA:
55.5
4cwyB-3e7gA:
17.2		 4cwyA-3e7gA:
58.03
4cwyB-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 8 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.47A 4cx7A-3e7gA:
60.7
4cx7B-3e7gA:
60.5		 4cx7A-3e7gA:
100.00
4cx7B-3e7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.42A 4cx7A-3e7gA:
60.7
4cx7B-3e7gA:
60.5		 4cx7A-3e7gA:
100.00
4cx7B-3e7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 TRP A 461
PHE A 476
HIS A 477
GLU A 479
 None
 0.12A 4cx7A-3e7gA:
60.7
4cx7B-3e7gA:
60.5		 4cx7A-3e7gA:
100.00
4cx7B-3e7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 8 SER A 118
MET A 120
ARG A 381
ILE A 462
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.53A 4cx7C-3e7gA:
19.6
4cx7D-3e7gA:
14.0		 4cx7C-3e7gA:
100.00
4cx7D-3e7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.47A 4cx7C-3e7gA:
19.6
4cx7D-3e7gA:
14.0		 4cx7C-3e7gA:
100.00
4cx7D-3e7gA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 SER A 118
MET A 120
ARG A 381
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 ( 3.6A)
 0.61A 4d32A-3e7gA:
56.7
4d32B-3e7gA:
57.0		 4d32A-3e7gA:
65.64
4d32B-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 GLY A 202
ILE A 204
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.24A 4d33A-3e7gA:
54.1		 4d33A-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 8 ARG A 266
ASN A 283
GLU A 285
ASN A 354
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
None
 1.00A 4d33A-3e7gA:
54.1		 4d33A-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 GLY A 202
ILE A 204
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
HEM  A 901 ( 3.7A)
None
 0.22A 4d33B-3e7gA:
54.4		 4d33B-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 ARG A 266
ASN A 283
GLU A 285
ASN A 354
 AT2  A 906 (-3.6A)
None
None
None
 1.02A 4d33B-3e7gA:
54.4		 4d33B-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
GLU A 285
ASN A 354
 AT2  A 906 (-3.6A)
None
None
None
 1.06A 4d39A-3e7gA:
55.5		 4d39A-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
GLU A 285
ASN A 354
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 0.85A 4d39A-3e7gA:
55.5		 4d39A-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 6 GLY A 202
ILE A 204
GLN A 205
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
None
HEM  A 901 ( 3.7A)
None
 0.20A 4d39B-3e7gA:
55.7		 4d39B-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 ARG A 266
ASN A 283
GLU A 285
ASN A 354
 AT2  A 906 (-3.6A)
None
None
None
 1.08A 4d39B-3e7gA:
55.7		 4d39B-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JS9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.38A 4js9A-3e7gA:
59.7		 4js9A-3e7gA:
87.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JS9_B_H4BB901_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.38A 4js9B-3e7gA:
59.6		 4js9B-3e7gA:
87.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 6 GLY A 202
ILE A 204
GLN A 205
TRP A 372
SER A 442
 HEM  A 901 ( 3.8A)
None
None
HEM  A 901 ( 3.7A)
None
 0.61A 4kcnA-3e7gA:
57.2		 4kcnA-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		6 / 6 ARG A 266
GLU A 377
ARG A 381
ASP A 382
ASP A 385
ARG A 388
 AT2  A 906 (-3.6A)
AT2  A 906 ( 2.7A)
H4B  A 902 (-3.9A)
AT2  A 906 (-4.4A)
None
AT2  A 906 (-3.1A)
 0.50A 4kcnA-3e7gA:
57.2		 4kcnA-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		6 / 6 ARG A 266
GLU A 377
ARG A 381
ASP A 382
ASP A 385
ARG A 388
 AT2  A 906 (-3.6A)
AT2  A 906 ( 2.7A)
H4B  A 902 (-3.9A)
AT2  A 906 (-4.4A)
None
AT2  A 906 (-3.1A)
 0.51A 4kcnB-3e7gA:
57.5		 4kcnB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.05A 4kcnB-3e7gA:
57.5		 4kcnB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NOS_B_H4BB1011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.33A 4nosA-3e7gA:
61.2
4nosB-3e7gA:
61.3		 4nosA-3e7gA:
99.76
4nosB-3e7gA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NOS_C_H4BC2011_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.30A 4nosC-3e7gA:
61.3
4nosD-3e7gA:
61.4		 4nosC-3e7gA:
99.76
4nosD-3e7gA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 LEU A 186
GLY A 183
GLU A 185
GLU A 172
 None
 0.70A 4rjdA-3e7gA:
undetectable
4rjdB-3e7gA:
undetectable		 4rjdA-3e7gA:
12.50
4rjdB-3e7gA:
12.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.23A 4uchA-3e7gA:
57.0
4uchB-3e7gA:
56.8		 4uchA-3e7gA:
65.88
4uchB-3e7gA:
65.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UX6_B_H4BB1498_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 4 MET A 120
ARG A 381
ILE A 462
TRP A 463
 H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 (-4.9A)
H4B  A 902 ( 3.6A)
 0.27A 4ux6B-3e7gA:
58.9		 4ux6B-3e7gA:
89.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.23A 4v3wA-3e7gA:
57.1
4v3wB-3e7gA:
57.3		 4v3wA-3e7gA:
65.64
4v3wB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 SER A 118
MET A 120
ARG A 381
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 ( 3.6A)
 0.51A 4v3yA-3e7gA:
56.9
4v3yB-3e7gA:
57.3		 4v3yA-3e7gA:
65.64
4v3yB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A 461
PHE A 476
HIS A 477
GLU A 479
 None
 0.18A 5ad9A-3e7gA:
56.4
5ad9B-3e7gA:
56.6		 5ad9A-3e7gA:
65.64
5ad9B-3e7gA:
65.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 PHE A 302
ARG A 301
GLU A 343
GLU A 394
 None
 1.02A 5h4dA-3e7gA:
undetectable		 5h4dA-3e7gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 PHE A 302
ARG A 301
GLU A 394
VAL A 395
 None
 1.39A 5h4dA-3e7gA:
undetectable		 5h4dA-3e7gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ARG A 203
PRO A 458
ASN A 482
 None
 1.05A 5jwaA-3e7gA:
undetectable
5jwaH-3e7gA:
undetectable		 5jwaA-3e7gA:
21.38
5jwaH-3e7gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 ARG A 195
ALA A 193
PRO A 487
PHE A 188
 None
 1.04A 5odqA-3e7gA:
undetectable		 5odqA-3e7gA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 PHE A 302
ASP A 280
LEU A 307
 None
 0.81A 5uhbC-3e7gA:
undetectable		 5uhbC-3e7gA:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 SER A 118
MET A 120
ARG A 381
TRP A 463
 None
H4B  A 902 (-3.8A)
H4B  A 902 (-3.9A)
H4B  A 902 ( 3.6A)
 0.65A 5uo7A-3e7gA:
57.2
5uo7B-3e7gA:
56.7		 5uo7A-3e7gA:
65.80
5uo7B-3e7gA:
65.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.26A 5uo9A-3e7gA:
54.5
5uo9B-3e7gA:
55.3		 5uo9A-3e7gA:
58.24
5uo9B-3e7gA:
58.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.22A 5uo9C-3e7gA:
55.0
5uo9D-3e7gA:
55.6		 5uo9C-3e7gA:
58.24
5uo9D-3e7gA:
58.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.02A 5vunA-3e7gA:
57.3		 5vunA-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.03A 5vunA-3e7gA:
57.3		 5vunA-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.05A 5vunB-3e7gA:
57.6		 5vunB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.01A 5vunB-3e7gA:
57.6		 5vunB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		5 / 8 ARG A 266
ASN A 283
PHE A 286
ASN A 354
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
None
 1.11A 5vuoB-3e7gA:
57.5		 5vuoB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.27A 5vv9A-3e7gA:
55.2
5vv9B-3e7gA:
19.4		 5vv9A-3e7gA:
58.03
5vv9B-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.27A 5vvaA-3e7gA:
55.2
5vvaB-3e7gA:
55.1		 5vvaA-3e7gA:
58.03
5vvaB-3e7gA:
58.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.26A 5vvdA-3e7gA:
55.2
5vvdB-3e7gA:
55.5		 5vvdA-3e7gA:
58.24
5vvdB-3e7gA:
58.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.15A 6auuA-3e7gA:
57.3
6auuB-3e7gA:
57.4		 6auuA-3e7gA:
10.58
6auuB-3e7gA:
10.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ARG A 266
ASN A 283
PHE A 286
TRP A 496
 AT2  A 906 (-3.6A)
None
None
None
 1.05A 6auuB-3e7gA:
57.4		 6auuB-3e7gA:
65.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 8 ASN A 283
PHE A 286
ASN A 354
TRP A 496
 None
 1.02A 6auuB-3e7gA:
57.4		 6auuB-3e7gA:
65.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.21A 6av6A-3e7gA:
42.7
6av6B-3e7gA:
55.7		 6av6A-3e7gA:
11.57
6av6B-3e7gA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 6 PHE A 247
ARG A 258
ALA A 214
GLN A 310
 None
 1.03A 6b89B-3e7gA:
undetectable		 6b89B-3e7gA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		3 / 3 ILE A 107
ASN A 482
CYH A 115
 None
None
ZN  A3001 (-2.6A)
 0.84A 6bp4A-3e7gA:
undetectable		 6bp4A-3e7gA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.21A 6cieA-3e7gA:
54.6
6cieB-3e7gA:
55.5		 6cieA-3e7gA:
11.57
6cieB-3e7gA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 7 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.20A 6cifC-3e7gA:
55.1
6cifD-3e7gA:
55.6		 6cifC-3e7gA:
11.57
6cifD-3e7gA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE
(Homo
sapiens) 		4 / 5 GLY A 269
ASN A 283
ASP A 280
ARG A 266
 None
None
None
AT2  A 906 (-3.6A)
 1.32A 6dwdB-3e7gA:
undetectable
6dwdD-3e7gA:
undetectable		 6dwdB-3e7gA:
22.02
6dwdD-3e7gA:
22.02