SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
3 / 3 LEU A  27
SER A  22
ASN A 189
None
0.77A 1bx4A-3e7wA:
undetectable
1bx4A-3e7wA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
None
1.07A 1cqeA-3e7wA:
undetectable
1cqeA-3e7wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
None
1.07A 1cqeB-3e7wA:
undetectable
1cqeB-3e7wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
3 / 3 PHE A  69
LEU A 212
SER A 198
None
0.84A 1e7aA-3e7wA:
undetectable
1e7aA-3e7wA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 8 ALA A 426
LEU A 410
ARG A 494
LEU A 465
None
0.87A 1ereE-3e7wA:
undetectable
1ereE-3e7wA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 8 ALA A 426
LEU A 410
ARG A 494
LEU A 465
None
0.87A 1ereF-3e7wA:
undetectable
1ereF-3e7wA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 11 LEU A 226
ALA A 191
MET A  61
LEU A 235
HIS A  60
None
1.27A 1iiuA-3e7wA:
undetectable
1iiuA-3e7wA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 VAL A 215
SER A 240
LEU A 230
LEU A 235
PHE A 267
None
1.10A 1mx1E-3e7wA:
undetectable
1mx1E-3e7wA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 TYR A 358
PRO A 158
VAL A  82
ILE A 148
LEU A  56
None
1.29A 1z9hA-3e7wA:
undetectable
1z9hA-3e7wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 TYR A 358
PRO A 158
VAL A  82
ILE A 148
LEU A  56
None
1.29A 1z9hB-3e7wA:
undetectable
1z9hB-3e7wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 TYR A 358
PRO A 158
VAL A  82
ILE A 148
LEU A  56
None
1.28A 1z9hC-3e7wA:
undetectable
1z9hC-3e7wA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
6 / 12 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
LEU A  32
None
1.39A 2aylA-3e7wA:
undetectable
2aylA-3e7wA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
6 / 12 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
LEU A  32
None
1.43A 2aylB-3e7wA:
undetectable
2aylB-3e7wA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 6 VAL A 423
LEU A 465
PHE A 415
HIS A 416
None
1.32A 2f8dA-3e7wA:
undetectable
2f8dA-3e7wA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 8 PRO A 180
VAL A 181
SER A 182
ALA A 177
None
1.10A 2v41G-3e7wA:
undetectable
2v41H-3e7wA:
undetectable
2v41G-3e7wA:
18.68
2v41H-3e7wA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 7 LEU A 197
GLY A 294
THR A 296
ARG A 407
None
AMP  A 513 (-4.9A)
AMP  A 513 (-4.0A)
AMP  A 513 (-3.8A)
0.60A 2wd9A-3e7wA:
38.7
2wd9A-3e7wA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 8 LEU A 197
GLY A 294
THR A 296
ARG A 407
None
AMP  A 513 (-4.9A)
AMP  A 513 (-4.0A)
AMP  A 513 (-3.8A)
0.68A 2wd9B-3e7wA:
40.4
2wd9B-3e7wA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
6 / 10 THR A 151
LEU A 197
GLY A 269
GLY A 294
THR A 296
ARG A 407
None
None
AMP  A 513 (-3.5A)
AMP  A 513 (-4.9A)
AMP  A 513 (-4.0A)
AMP  A 513 (-3.8A)
1.01A 2wd9C-3e7wA:
40.1
2wd9C-3e7wA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 7 VAL A 302
THR A 303
ILE A 329
ILE A 347
None
0.80A 3deuA-3e7wA:
undetectable
3deuA-3e7wA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
6 / 12 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
LEU A  32
None
1.35A 3n8wA-3e7wA:
undetectable
3n8wA-3e7wA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
None
0.95A 3rr3C-3e7wA:
undetectable
3rr3C-3e7wA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 TYR A 203
LEU A 206
VAL A  73
GLY A  71
SER A  36
None
1.09A 3rr3C-3e7wA:
undetectable
3rr3C-3e7wA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
None
0.95A 3rr3D-3e7wA:
undetectable
3rr3D-3e7wA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 TYR A 203
LEU A 206
VAL A  73
GLY A  71
SER A  36
None
1.08A 3rr3D-3e7wA:
undetectable
3rr3D-3e7wA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 7 ASP A 196
GLY A 269
THR A 296
LYS A 402
AMP  A 513 ( 4.4A)
AMP  A 513 (-3.5A)
AMP  A 513 (-4.0A)
AMP  A 513 (-2.6A)
1.09A 3vnsA-3e7wA:
46.2
3vnsA-3e7wA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
3 / 3 LYS A 477
TYR A 439
ARG A 476
None
1.32A 4gc9A-3e7wA:
undetectable
4gc9A-3e7wA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 TYR A  29
PRO A 204
GLN A 207
ALA A   6
LEU A   3
None
1.26A 4j7xB-3e7wA:
undetectable
4j7xB-3e7wA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 8 PRO A 273
SER A 275
VAL A 276
GLY A 435
None
0.52A 4mk4A-3e7wA:
3.3
4mk4A-3e7wA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
3 / 3 SER A 170
ASP A 326
GLN A 375
None
0.90A 4oltA-3e7wA:
undetectable
4oltB-3e7wA:
undetectable
4oltA-3e7wA:
18.57
4oltB-3e7wA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 10 LEU A 206
CYH A 214
LEU A 212
ALA A  19
LEU A  32
None
1.09A 4p65A-3e7wA:
undetectable
4p65B-3e7wA:
undetectable
4p65F-3e7wA:
undetectable
4p65H-3e7wA:
undetectable
4p65A-3e7wA:
3.91
4p65B-3e7wA:
7.97
4p65F-3e7wA:
7.97
4p65H-3e7wA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 11 LEU A 206
CYH A 214
LEU A 212
ALA A  19
LEU A  32
None
1.08A 4p65C-3e7wA:
undetectable
4p65D-3e7wA:
undetectable
4p65J-3e7wA:
undetectable
4p65L-3e7wA:
undetectable
4p65C-3e7wA:
3.91
4p65D-3e7wA:
7.97
4p65J-3e7wA:
7.97
4p65L-3e7wA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 11 LEU A  32
LEU A 206
CYH A 214
LEU A 212
ALA A  19
None
1.08A 4p65B-3e7wA:
undetectable
4p65D-3e7wA:
undetectable
4p65G-3e7wA:
undetectable
4p65H-3e7wA:
undetectable
4p65B-3e7wA:
7.97
4p65D-3e7wA:
7.97
4p65G-3e7wA:
3.91
4p65H-3e7wA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
3 / 3 GLN A 375
SER A 170
ASP A 326
None
0.89A 4qwpA-3e7wA:
undetectable
4qwpB-3e7wA:
undetectable
4qwpA-3e7wA:
18.57
4qwpB-3e7wA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 ILE A  66
ALA A  19
SER A  36
LEU A  70
LEU A   3
None
1.31A 4qztC-3e7wA:
undetectable
4qztC-3e7wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 5 LEU A 127
ALA A  40
VAL A  57
ILE A  55
None
0.90A 4xe3B-3e7wA:
undetectable
4xe3B-3e7wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
4 / 6 PHE A 193
PRO A 192
MET A  61
LEU A 197
None
1.49A 5dzka-3e7wA:
undetectable
5dzko-3e7wA:
undetectable
5dzka-3e7wA:
18.00
5dzko-3e7wA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 LEU A   4
TYR A 203
VAL A  73
GLY A  71
SER A  36
None
1.07A 5ikrA-3e7wA:
undetectable
5ikrA-3e7wA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis)
5 / 12 LEU A   4
TYR A 203
LEU A 206
GLY A  71
SER A  36
None
1.06A 5ikrB-3e7wA:
undetectable
5ikrB-3e7wA:
21.34