SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 9 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.36A 1ereA-3e8jA:
undetectable		 1ereA-3e8jA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 9 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.36A 1ereB-3e8jA:
undetectable		 1ereB-3e8jA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 9 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.37A 1ereC-3e8jA:
undetectable		 1ereC-3e8jA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 9 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.37A 1ereD-3e8jA:
undetectable		 1ereD-3e8jA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 8 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.35A 1ereE-3e8jA:
undetectable		 1ereE-3e8jA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 8 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.36A 1ereF-3e8jA:
undetectable		 1ereF-3e8jA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 6 LEU A  13
PHE A  63
TYR A  67
VAL A  92
 None
 1.16A 1ibgH-3e8jA:
undetectable		 1ibgH-3e8jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		3 / 3 PHE A 156
TRP A 194
GLU A 193
 None
 0.97A 1mogA-3e8jA:
undetectable		 1mogA-3e8jA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 11 PHE A 145
GLY A 209
GLY A 207
LEU A  15
LEU A 186
 None
 1.00A 1mx1A-3e8jA:
undetectable		 1mx1A-3e8jA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 10 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.32A 1qkuA-3e8jA:
undetectable		 1qkuA-3e8jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 10 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.32A 1qkuB-3e8jA:
undetectable		 1qkuB-3e8jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 10 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.32A 1qkuC-3e8jA:
undetectable		 1qkuC-3e8jA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		3 / 3 ALA A  89
VAL A 114
TRP A 124
 None
None
GOL  A 305 (-4.0A)
 0.92A 1tkqB-3e8jA:
undetectable		 1tkqB-3e8jA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 10 ILE A 215
TYR A 214
ILE A  50
GLU A  26
ILE A  56
 None
 1.30A 2dm6A-3e8jA:
undetectable
2dm6B-3e8jA:
undetectable		 2dm6A-3e8jA:
23.70
2dm6B-3e8jA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 12 ARG A 111
ASP A  18
ILE A  19
ILE A 211
GLY A 209
 None
 0.91A 2o4nA-3e8jA:
undetectable		 2o4nA-3e8jA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 6 PHE A 187
PHE A 172
GLY A 251
ASN A 245
 None
None
None
ACT  A 302 (-3.1A)
 0.93A 2qr2A-3e8jA:
undetectable
2qr2B-3e8jA:
undetectable		 2qr2A-3e8jA:
22.57
2qr2B-3e8jA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 7 ARG A  48
ARG A  46
VAL A  61
VAL A  92
 None
 0.85A 3o14A-3e8jA:
undetectable		 3o14A-3e8jA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 8 GLN A 234
PRO A 101
TYR A 136
PRO A 134
 None
 1.05A 3oyaA-3e8jA:
undetectable		 3oyaA-3e8jA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		3 / 3 ARG A 238
ASP A  27
GLN A  29
 None
 0.91A 4azsA-3e8jA:
undetectable		 4azsA-3e8jA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 8 PHE A 187
PHE A 172
GLY A 251
ASN A 245
 None
None
None
ACT  A 302 (-3.1A)
 0.91A 4fgjA-3e8jA:
undetectable
4fgjB-3e8jA:
undetectable		 4fgjA-3e8jA:
22.29
4fgjB-3e8jA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 4 ILE A  19
VAL A  95
VAL A  61
ARG A  48
 None
ACT  A 302 (-4.7A)
None
None
 1.11A 4m6tA-3e8jA:
undetectable		 4m6tA-3e8jA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 8 PHE A 187
PHE A 172
GLY A 251
ASN A 245
 None
None
None
ACT  A 302 (-3.1A)
 0.94A 4qoiA-3e8jA:
undetectable
4qoiB-3e8jA:
undetectable		 4qoiA-3e8jA:
22.33
4qoiB-3e8jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 10 ALA A 180
GLU A 179
LEU A 290
ARG A 237
HIS A 146
 None
 1.38A 5dxeB-3e8jA:
undetectable		 5dxeB-3e8jA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		3 / 3 ASP A 131
ARG A 250
ARG A 111
 None
 0.54A 5eajB-3e8jA:
undetectable		 5eajB-3e8jA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		5 / 10 PRO A  98
ILE A  19
VAL A 218
PHE A 210
SER A 106
 None
 1.27A 5tixB-3e8jA:
undetectable		 5tixB-3e8jA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		3 / 3 HIS A 107
SER A  93
ARG A 111
 ACT  A 302 (-3.0A)
None
None
 1.04A 5u63A-3e8jA:
undetectable		 5u63A-3e8jA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_A_NCAA402_0
(NADPH DEHYDROGENASE
3)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 8 THR A 133
ASN A 245
PRO A 270
TYR A 135
 None
ACT  A 302 (-3.1A)
None
None
 1.24A 5v4vA-3e8jA:
undetectable		 5v4vA-3e8jA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V4V_B_NCAB402_0
(NADPH DEHYDROGENASE
3)		 3e8j COPROPORPHYRINOGEN
III OXIDASE
(Leishmania
naiffi) 		4 / 8 THR A 133
ASN A 245
PRO A 270
TYR A 135
 None
ACT  A 302 (-3.1A)
None
None
 1.21A 5v4vB-3e8jA:
undetectable		 5v4vB-3e8jA:
20.78