SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 PHE A 185
ALA A 158
ILE A 149
THR A 151
MET A 221
 None
 1.12A 1crbA-3e8sA:
undetectable		 1crbA-3e8sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 6 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.78A 1mt1G-3e8sA:
undetectable
1mt1J-3e8sA:
undetectable		 1mt1G-3e8sA:
12.15
1mt1J-3e8sA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 7 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.82A 1mt1H-3e8sA:
undetectable
1mt1K-3e8sA:
undetectable		 1mt1H-3e8sA:
17.39
1mt1K-3e8sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 7 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.83A 1n13D-3e8sA:
undetectable
1n13E-3e8sA:
undetectable		 1n13D-3e8sA:
17.39
1n13E-3e8sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 8 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.79A 1n13A-3e8sA:
undetectable
1n13F-3e8sA:
undetectable		 1n13A-3e8sA:
12.15
1n13F-3e8sA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 6 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.84A 1n13H-3e8sA:
undetectable
1n13K-3e8sA:
undetectable		 1n13H-3e8sA:
17.39
1n13K-3e8sA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 7 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.81A 1n13G-3e8sA:
undetectable
1n13J-3e8sA:
undetectable		 1n13G-3e8sA:
12.15
1n13J-3e8sA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 8 ASP A 161
GLY A 165
ASP A 164
TYR A 162
 None
 1.02A 1rmtC-3e8sA:
2.8		 1rmtC-3e8sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		3 / 3 GLY A  59
ASP A  80
ASN A 122
 SAH  A 300 (-4.2A)
SAH  A 300 (-2.7A)
SAH  A 300 (-3.8A)
 0.54A 1vq1A-3e8sA:
11.3		 1vq1A-3e8sA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 LEU A 140
ILE A 119
VAL A  79
GLY A  78
LEU A 105
 None
 1.00A 2bxeB-3e8sA:
undetectable		 2bxeB-3e8sA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_2
(NEURAMINIDASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 5 LEU A 192
ARG A 186
TRP A 191
ILE A 130
 None
 1.11A 2cmlA-3e8sA:
undetectable		 2cmlA-3e8sA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_2
(NEURAMINIDASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 5 LEU A 192
ARG A 186
TRP A 191
ILE A 130
 None
 1.12A 2cmlB-3e8sA:
undetectable		 2cmlB-3e8sA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_2
(NEURAMINIDASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 5 LEU A 192
ARG A 186
TRP A 191
ILE A 130
 None
 1.12A 2cmlC-3e8sA:
undetectable		 2cmlC-3e8sA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_2
(NEURAMINIDASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 5 LEU A 192
ARG A 186
TRP A 191
ILE A 130
 None
 1.15A 2cmlD-3e8sA:
undetectable		 2cmlD-3e8sA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		6 / 12 ASP A  57
LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASN A 122
 SAH  A 300 ( 4.7A)
None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
SAH  A 300 (-3.8A)
 0.95A 2nxeA-3e8sA:
14.1		 2nxeA-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		6 / 12 ASP A  57
LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASP A  82
 SAH  A 300 ( 4.7A)
None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
None
 0.81A 2nxeA-3e8sA:
14.1		 2nxeA-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		6 / 12 LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASN A 122
LEU A 125
 None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
SAH  A 300 (-3.8A)
None
 1.17A 2nxeA-3e8sA:
14.1		 2nxeA-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 ASP A  57
LEU A  58
GLY A  59
GLY A  61
ASN A 122
 SAH  A 300 ( 4.7A)
None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.8A)
 0.75A 2nxeB-3e8sA:
14.5		 2nxeB-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 ASP A  57
LEU A  58
GLY A  59
GLY A  61
ASP A  82
 SAH  A 300 ( 4.7A)
None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
 0.46A 2nxeB-3e8sA:
14.5		 2nxeB-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 ASP A  57
LEU A  58
GLY A  61
LEU A  65
ASN A 122
 SAH  A 300 ( 4.7A)
None
SAH  A 300 (-3.1A)
None
SAH  A 300 (-3.8A)
 0.91A 2nxeB-3e8sA:
14.5		 2nxeB-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 11 LEU A 220
ILE A  43
ALA A 124
LEU A  65
ASP A  57
 None
None
SAH  A 300 ( 4.2A)
None
SAH  A 300 ( 4.7A)
 1.19A 2q72A-3e8sA:
undetectable		 2q72A-3e8sA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 8 LEU A  56
ASP A  57
LEU A  66
GLY A  63
 None
SAH  A 300 ( 4.7A)
None
None
 0.86A 2qqcH-3e8sA:
undetectable
2qqcK-3e8sA:
undetectable		 2qqcH-3e8sA:
19.69
2qqcK-3e8sA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASN A 122
 None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
SAH  A 300 (-3.8A)
 0.89A 2zbpA-3e8sA:
14.4		 2zbpA-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 4 VAL A  27
ASP A  82
LEU A  12
ARG A  35
 None
None
SAH  A 300 ( 4.8A)
SAH  A 300 (-2.9A)
 1.31A 2ziaA-3e8sA:
undetectable		 2ziaA-3e8sA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		6 / 12 ASP A  57
GLY A  59
LEU A  65
ASP A  80
ASP A  82
LEU A 126
 SAH  A 300 ( 4.7A)
SAH  A 300 (-4.2A)
None
SAH  A 300 (-2.7A)
None
None
 1.33A 3cjtC-3e8sA:
14.8		 3cjtC-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		6 / 12 ASP A  57
LEU A  58
GLY A  59
LEU A  65
ASP A  80
ASP A  82
 SAH  A 300 ( 4.7A)
None
SAH  A 300 (-4.2A)
None
SAH  A 300 (-2.7A)
None
 0.68A 3cjtC-3e8sA:
14.8		 3cjtC-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 LEU A  58
GLY A  59
GLY A  61
ASN A 122
LEU A 125
 None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-3.8A)
None
 0.92A 3cjtG-3e8sA:
14.9		 3cjtG-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASN A 122
 None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
SAH  A 300 (-3.8A)
 0.75A 3cjtG-3e8sA:
14.9		 3cjtG-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASP A  82
 None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
None
 0.77A 3cjtG-3e8sA:
14.9		 3cjtG-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		6 / 12 LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASN A 122
LEU A 125
 None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
SAH  A 300 (-3.8A)
None
 1.04A 3cjtO-3e8sA:
14.8		 3cjtO-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		6 / 12 LEU A  58
GLY A  59
GLY A  61
LEU A  65
ASP A  82
ASN A 122
 None
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
None
None
SAH  A 300 (-3.8A)
 0.87A 3cjtO-3e8sA:
14.8		 3cjtO-3e8sA:
27.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 8 ALA A 124
LEU A  58
ASP A  80
TYR A 102
 SAH  A 300 ( 4.2A)
None
SAH  A 300 (-2.7A)
SAH  A 300 (-3.6A)
 0.76A 3qj7A-3e8sA:
undetectable
3qj7D-3e8sA:
undetectable		 3qj7A-3e8sA:
23.26
3qj7D-3e8sA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 ARG A  35
GLY A  59
GLY A  61
ASP A  80
ALA A 124
 SAH  A 300 (-2.9A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-2.7A)
SAH  A 300 ( 4.2A)
 1.02A 3t7sA-3e8sA:
14.6		 3t7sA-3e8sA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_2
(NEURAMINIDASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 5 LEU A 192
ARG A 186
TRP A 191
ILE A 130
 None
 1.12A 3ticD-3e8sA:
undetectable		 3ticD-3e8sA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 8 VAL A 110
VAL A 112
GLN A 104
ARG A  83
 None
 1.16A 3uy4A-3e8sA:
2.4		 3uy4A-3e8sA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 12 ASN A 122
ALA A 121
LEU A 118
THR A  39
PHE A 123
 SAH  A 300 (-3.8A)
None
None
None
None
 1.40A 3vhuA-3e8sA:
undetectable		 3vhuA-3e8sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 5 LEU A 200
ILE A 149
ALA A 194
MET A 221
 None
 1.07A 4dc3B-3e8sA:
undetectable		 4dc3B-3e8sA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 11 ASP A  57
GLY A  59
GLY A  61
ASP A  80
ASN A 122
 SAH  A 300 ( 4.7A)
SAH  A 300 (-4.2A)
SAH  A 300 (-3.1A)
SAH  A 300 (-2.7A)
SAH  A 300 (-3.8A)
 0.97A 4dcmA-3e8sA:
11.8		 4dcmA-3e8sA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 5 LEU A 192
ARG A 186
TRP A 191
ILE A 130
 None
 1.10A 4mwrA-3e8sA:
undetectable		 4mwrA-3e8sA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		3 / 3 ARG A 186
TRP A 191
ILE A 130
 None
 0.85A 4mwxA-3e8sA:
undetectable		 4mwxA-3e8sA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 9 SER A 190
ALA A 189
LEU A 219
ILE A 149
 None
 0.93A 4xtaA-3e8sA:
undetectable		 4xtaA-3e8sA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_A_010A609_0
(HNL ISOENZYME 5)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		5 / 11 ALA A 194
ALA A 198
LEU A 134
LEU A 125
TRP A 191
 None
 1.26A 5eb5A-3e8sA:
undetectable		 5eb5A-3e8sA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L17_A_ZMRA512_2
(NEURAMINIDASE)		 3e8s PUTATIVE SAM
DEPENDENT
METHYLTRANSFERASE
(Pseudomonas
putida) 		4 / 4 LEU A 192
ARG A 186
TRP A 191
ILE A 130
 None
 1.09A 5l17A-3e8sA:
undetectable		 5l17A-3e8sA:
18.50