SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 10 SER A 110
VAL A 111
TYR A 126
GLY A 150
PRO A 151
 NAP  A 500 (-3.1A)
None
NAP  A 500 (-4.5A)
None
NAP  A 500 ( 4.9A)
 0.77A 1equA-3e8xA:
17.7		 1equA-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 12 SER A 110
VAL A 111
TYR A 126
GLY A 150
PRO A 151
 NAP  A 500 (-3.1A)
None
NAP  A 500 (-4.5A)
None
NAP  A 500 ( 4.9A)
 0.77A 1fdsA-3e8xA:
19.5		 1fdsA-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 12 SER A 110
VAL A 111
GLY A 112
GLY A 150
PRO A 151
 NAP  A 500 (-3.1A)
None
CL  A 501 (-3.3A)
None
NAP  A 500 ( 4.9A)
 0.69A 1fduA-3e8xA:
17.6		 1fduA-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 12 SER A 110
VAL A 111
TYR A 126
GLY A 150
PRO A 151
 NAP  A 500 (-3.1A)
None
NAP  A 500 (-4.5A)
None
NAP  A 500 ( 4.9A)
 0.69A 1fduA-3e8xA:
17.6		 1fduA-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		4 / 8 SER A 110
VAL A 111
TYR A 126
PRO A 151
 NAP  A 500 (-3.1A)
None
NAP  A 500 (-4.5A)
NAP  A 500 ( 4.9A)
 1.00A 1fduB-3e8xA:
17.6		 1fduB-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 12 SER A 110
VAL A 111
GLY A 112
GLY A 150
PRO A 151
 NAP  A 500 (-3.1A)
None
CL  A 501 (-3.3A)
None
NAP  A 500 ( 4.9A)
 0.72A 1fduC-3e8xA:
17.6		 1fduC-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 12 SER A 110
VAL A 111
TYR A 126
GLY A 150
PRO A 151
 NAP  A 500 (-3.1A)
None
NAP  A 500 (-4.5A)
None
NAP  A 500 ( 4.9A)
 0.71A 1fduC-3e8xA:
17.6		 1fduC-3e8xA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 11 SER A 109
ILE A  94
ALA A  90
LEU A  87
ALA A 129
 None
 1.34A 1jb0B-3e8xA:
undetectable		 1jb0B-3e8xA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 11 ASN A   9
VAL A   5
ALA A  13
LEU A  17
ARG A  43
 NAP  A 500 (-3.6A)
None
None
None
None
 1.05A 2bxgA-3e8xA:
undetectable		 2bxgA-3e8xA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		4 / 5 LEU A 200
ILE A 174
LEU A 152
SER A 153
 None
None
NAP  A 500 (-3.8A)
None
 0.97A 2byoA-3e8xA:
undetectable		 2byoA-3e8xA:
26.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 11 SER A 109
ILE A  94
ALA A  90
LEU A  87
ALA A 129
 None
 1.33A 3pcqB-3e8xA:
undetectable		 3pcqB-3e8xA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 9 SER A 109
ILE A  94
ALA A  90
LEU A  87
ALA A 129
 None
 1.38A 4fe1B-3e8xA:
undetectable		 4fe1B-3e8xA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 10 SER A 109
ILE A  94
ALA A  90
LEU A  87
ALA A 129
 None
 1.37A 4xk8B-3e8xA:
undetectable		 4xk8B-3e8xA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 10 SER A 109
ILE A  94
ALA A  90
LEU A  87
ALA A 129
 None
 1.42A 5oy0b-3e8xA:
undetectable		 5oy0b-3e8xA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3e8x PUTATIVE
NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E
(Bacillus
halodurans) 		5 / 9 SER A 109
ILE A  94
ALA A  90
LEU A  87
ALA A 129
 None
 1.47A 6hqbB-3e8xA:
undetectable		 6hqbB-3e8xA:
14.41