SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e96'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		3 / 3 GLU A 228
LYS A 222
VAL A 224
 None
 0.93A 1l2iA-3e96A:
undetectable		 1l2iA-3e96A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 11 THR A 212
GLY A  17
GLU A 197
GLU A 249
ILE A  42
 None
 1.36A 1odiC-3e96A:
undetectable		 1odiC-3e96A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 11 THR A 212
GLY A  17
GLU A 197
GLU A 249
ILE A  42
 None
 1.34A 1odiD-3e96A:
undetectable		 1odiD-3e96A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_D_DVAD8_0
(GRAMICIDIN D)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		3 / 3 VAL A 166
VAL A 164
TRP A 191
 None
 0.95A 1w5uC-3e96A:
undetectable
1w5uD-3e96A:
undetectable		 1w5uC-3e96A:
4.56
1w5uD-3e96A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 11 ALA A 223
GLU A 197
ILE A 245
ALA A 196
ASP A 244
 None
 1.11A 2admA-3e96A:
undetectable		 2admA-3e96A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 11 ALA A 223
GLU A 197
ILE A 245
ALA A 196
ASP A 244
 None
 1.11A 2admB-3e96A:
undetectable		 2admB-3e96A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 7 ALA A 177
GLY A 207
ASP A 151
ARG A 175
 None
 0.83A 2uyqA-3e96A:
undetectable		 2uyqA-3e96A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 8 GLY A  54
ILE A 264
ASN A 217
GLU A  58
 None
 0.89A 2x0pA-3e96A:
undetectable		 2x0pA-3e96A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		3 / 3 ASP A 244
THR A  14
GLU A 197
 None
 0.73A 2zifB-3e96A:
undetectable		 2zifB-3e96A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		3 / 3 GLY A 165
PRO A 139
LEU A   8
 None
 0.62A 3hcpB-3e96A:
undetectable		 3hcpB-3e96A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 7 LEU A  12
VAL A 125
ILE A 112
ARG A 152
 None
 1.32A 3ik3A-3e96A:
undetectable		 3ik3A-3e96A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 7 LEU A  12
VAL A 125
ILE A 112
ARG A 152
 None
 1.31A 3ik3B-3e96A:
undetectable		 3ik3B-3e96A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		3 / 3 VAL A 166
VAL A 164
TRP A 191
 None
 0.95A 3l8lC-3e96A:
undetectable
3l8lD-3e96A:
undetectable		 3l8lC-3e96A:
4.56
3l8lD-3e96A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 6 ILE A 245
GLU A 249
PHE A 211
ALA A 200
 None
 0.97A 3pgyA-3e96A:
2.9
3pgyB-3e96A:
3.0		 3pgyA-3e96A:
24.03
3pgyB-3e96A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 11 THR A  14
ALA A 190
ILE A 192
PHE A 211
GLU A 185
 None
 1.49A 3qelA-3e96A:
undetectable
3qelB-3e96A:
undetectable		 3qelA-3e96A:
19.80
3qelB-3e96A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 12 THR A  21
PRO A  22
PRO A  19
ASN A 217
ILE A  50
 None
 1.40A 4eb6B-3e96A:
undetectable
4eb6C-3e96A:
undetectable		 4eb6B-3e96A:
21.81
4eb6C-3e96A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 10 THR A  14
ALA A 190
ILE A 192
PHE A 211
GLU A 185
 None
 1.43A 4pe5A-3e96A:
2.0
4pe5B-3e96A:
undetectable		 4pe5A-3e96A:
17.01
4pe5B-3e96A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 10 THR A  14
ALA A 190
ILE A 192
PHE A 211
GLU A 185
 None
 1.47A 4pe5C-3e96A:
1.3
4pe5D-3e96A:
undetectable		 4pe5C-3e96A:
17.01
4pe5D-3e96A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 6 ILE A 170
VAL A 166
PHE A 203
THR A 212
 None
 1.14A 4xe5A-3e96A:
undetectable		 4xe5A-3e96A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 11 ALA A 275
TYR A  35
GLY A 214
VAL A 261
SER A  57
 None
 1.06A 4xnxA-3e96A:
undetectable		 4xnxA-3e96A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 11 ASP A 131
VAL A 142
ILE A 112
ALA A 135
ILE A  96
 None
 1.21A 5d75A-3e96A:
undetectable		 5d75A-3e96A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 11 THR A  14
ALA A 190
ILE A 192
PHE A 211
GLU A 185
 None
 1.50A 5ewjA-3e96A:
2.1
5ewjB-3e96A:
undetectable		 5ewjA-3e96A:
19.71
5ewjB-3e96A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 12 THR A  14
ALA A 190
ILE A 192
PHE A 211
GLU A 185
 None
 1.46A 5ewjC-3e96A:
undetectable
5ewjD-3e96A:
undetectable		 5ewjC-3e96A:
19.71
5ewjD-3e96A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 12 LEU A 227
LEU A 230
GLY A 210
GLY A 194
LYS A 222
 None
 1.08A 6ce2B-3e96A:
undetectable		 6ce2B-3e96A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 12 LEU A 297
LEU A 218
PHE A 248
ILE A 264
VAL A 261
 None
 1.17A 6debB-3e96A:
undetectable		 6debB-3e96A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 8 ASP A 151
ILE A 149
ARG A 175
TYR A 143
 None
 1.13A 6hisA-3e96A:
undetectable
6hisB-3e96A:
undetectable		 6hisA-3e96A:
12.21
6hisB-3e96A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 8 ASP A 151
ILE A 149
ARG A 175
TYR A 143
 None
 1.13A 6hisB-3e96A:
undetectable
6hisC-3e96A:
undetectable		 6hisB-3e96A:
12.21
6hisC-3e96A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 8 ASP A 151
ILE A 149
ARG A 175
TYR A 143
 None
 1.13A 6hisC-3e96A:
undetectable
6hisD-3e96A:
undetectable		 6hisC-3e96A:
12.21
6hisD-3e96A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 8 ASP A 151
ILE A 149
ARG A 175
TYR A 143
 None
 1.13A 6hisD-3e96A:
undetectable
6hisE-3e96A:
undetectable		 6hisD-3e96A:
12.21
6hisE-3e96A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		4 / 8 TYR A 143
ASP A 151
ILE A 149
ARG A 175
 None
 1.14A 6hisA-3e96A:
undetectable
6hisE-3e96A:
undetectable		 6hisA-3e96A:
12.21
6hisE-3e96A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3e96 DIHYDRODIPICOLINATE
SYNTHASE
(Bacillus
clausii) 		5 / 9 ILE A  50
ILE A  47
GLU A  76
VAL A  39
ILE A  42
 None
 1.20A 6hloA-3e96A:
undetectable		 6hloA-3e96A:
19.16