SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e97'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		4 / 5 THR A 147
LEU A 151
VAL A 154
GLN A 161
 None
 0.92A 1fbmE-3e97A:
undetectable		 1fbmE-3e97A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		4 / 5 THR A 147
VAL A 154
LEU A 158
GLN A 161
 None
 0.87A 1fbmE-3e97A:
undetectable		 1fbmE-3e97A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		5 / 11 LEU A  49
PHE A 111
GLY A  81
LEU A  12
LEU A  51
 None
 1.18A 1mx1B-3e97A:
undetectable		 1mx1B-3e97A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		4 / 4 THR A 147
LEU A 151
VAL A 154
LEU A 158
 None
 0.57A 1mz9D-3e97A:
undetectable		 1mz9D-3e97A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		4 / 6 VAL A  28
THR A  29
GLU A  41
LEU A 106
 None
 0.97A 1s8fB-3e97A:
undetectable		 1s8fB-3e97A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_B_SALB1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		5 / 9 ARG A  31
THR A  29
VAL A  28
LEU A 106
ALA A  48
 None
 1.45A 3ax7B-3e97A:
undetectable		 3ax7B-3e97A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		5 / 9 PHE A 155
LEU A 195
VAL A 191
LEU A 175
ILE A 180
 None
 1.12A 3tbgD-3e97A:
undetectable		 3tbgD-3e97A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		3 / 3 GLU A  23
ARG A 117
HIS A 118
 None
 0.85A 4kf9A-3e97A:
undetectable		 4kf9A-3e97A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		5 / 12 LEU A 204
VAL A 211
GLU A 148
ALA A 142
GLY A 144
 None
 0.86A 5uxdB-3e97A:
undetectable		 5uxdB-3e97A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		3 / 3 THR A 147
THR A 190
ARG A 193
 None
 1.02A 5wm2A-3e97A:
undetectable		 5wm2A-3e97A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY
(Deinococcus
geothermalis) 		4 / 5 GLU A  23
HIS A 118
LEU A  12
VAL A 121
 None
 1.20A 6bc9A-3e97A:
undetectable		 6bc9A-3e97A:
14.72