SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e98'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 192
SER A 120
PHE A 167
GLY A 168
 None
 0.83A 1fapB-3e98A:
undetectable		 1fapB-3e98A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		5 / 8 PHE A 124
ILE A 122
PHE A 165
LEU A 148
VAL A 191
 None
 1.34A 1fslA-3e98A:
undetectable		 1fslA-3e98A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 148
VAL A 135
LEU A 123
VAL A 181
 None
 0.95A 2bdmA-3e98A:
undetectable		 2bdmA-3e98A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		4 / 7 ARG A 220
VAL A 119
LEU A 123
ILE A 194
 None
 0.97A 3gp0A-3e98A:
undetectable		 3gp0A-3e98A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		4 / 7 LEU A  99
SER A  98
LEU A 183
ARG A 224
 None
 0.86A 3ln1B-3e98A:
undetectable		 3ln1B-3e98A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		4 / 7 ILE A 144
LEU A 148
LEU A 183
VAL A 106
 None
 0.91A 3r9vA-3e98A:
2.6
3r9vB-3e98A:
2.4		 3r9vA-3e98A:
23.40
3r9vB-3e98A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 124
SER A 182
LEU A 147
VAL A 180
ALA A 143
 None
None
None
EDO  A 236 ( 4.8A)
None
 1.45A 3u9fD-3e98A:
undetectable
3u9fE-3e98A:
undetectable		 3u9fD-3e98A:
20.73
3u9fE-3e98A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		4 / 5 VAL A 191
LEU A 148
ILE A 144
VAL A 135
 None
 0.98A 4a9kB-3e98A:
undetectable		 4a9kB-3e98A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 212
VAL A 106
THR A 105
ALA A 219
LEU A 218
 EDO  A 234 ( 4.8A)
None
None
EDO  A 234 (-3.4A)
None
 1.00A 5kocA-3e98A:
undetectable		 5kocA-3e98A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_A_OAQA302_0
(SULFOTRANSFERASE)		 3e98 GAF DOMAIN OF
UNKNOWN FUNCTION
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 181
VAL A 180
LEU A 123
LEU A 218
LEU A 222
 None
EDO  A 236 ( 4.8A)
None
None
None
 1.12A 5tiwA-3e98A:
undetectable		 5tiwA-3e98A:
17.74