SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 12 THR A 455
LEU A 458
ILE A 457
ASN A 411
PHE A 450
 None
 1.28A 1wsvA-3e9kA:
undetectable		 1wsvA-3e9kA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 12 THR A 455
LEU A 458
ILE A 457
ASN A 411
PHE A 450
 None
 1.35A 1wsvB-3e9kA:
undetectable		 1wsvB-3e9kA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3e9k KYNURENINASE
(Homo
sapiens) 		4 / 8 ILE A 372
PHE A 407
LEU A 458
ILE A 457
 None
 0.93A 2azxA-3e9kA:
2.5		 2azxA-3e9kA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 9 LEU A 133
ASP A 113
ILE A 331
GLY A 307
ILE A 323
 None
 1.14A 3d1yB-3e9kA:
undetectable		 3d1yB-3e9kA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 11 ALA A 216
GLY A 240
GLY A 244
ILE A 158
VAL A 247
 None
 0.91A 3dcmX-3e9kA:
undetectable		 3dcmX-3e9kA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 12 ASN A  74
TYR A 277
ASN A 442
TYR A 441
LEU A  78
 None
 1.33A 3ooiA-3e9kA:
undetectable		 3ooiA-3e9kA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 12 ILE A  69
PHE A 450
ILE A 457
LEU A 458
VAL A 388
 None
 1.13A 3w68B-3e9kA:
undetectable		 3w68B-3e9kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7B_C_ACTC513_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3e9k KYNURENINASE
(Homo
sapiens) 		3 / 3 TYR A  86
HIS A 343
ARG A 107
 None
 1.19A 4e7bC-3e9kA:
undetectable		 4e7bC-3e9kA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 11 ASN A  74
TYR A 277
ASN A 442
TYR A 441
LEU A  78
 None
 1.39A 5updA-3e9kA:
undetectable		 5updA-3e9kA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 10 LEU A 368
THR A 365
GLY A 400
ILE A 405
ILE A 390
 None
 0.96A 6ebpD-3e9kA:
undetectable		 6ebpD-3e9kA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 11 LEU A 368
THR A 365
GLY A 400
ILE A 405
ILE A 390
 None
 1.01A 6ebzA-3e9kA:
undetectable		 6ebzA-3e9kA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 11 LEU A 368
THR A 365
GLY A 400
ILE A 405
ILE A 390
 None
 1.00A 6ebzB-3e9kA:
undetectable		 6ebzB-3e9kA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 11 LEU A 368
THR A 365
GLY A 400
ILE A 405
ILE A 390
 None
 1.03A 6ebzC-3e9kA:
undetectable		 6ebzC-3e9kA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 11 LEU A 368
THR A 365
GLY A 400
ILE A 405
ILE A 390
 None
 0.97A 6ebzD-3e9kA:
undetectable		 6ebzD-3e9kA:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 11 LEU A 368
THR A 365
GLY A 400
ILE A 405
ILE A 390
 None
 0.96A 6gp2A-3e9kA:
undetectable		 6gp2A-3e9kA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 3e9k KYNURENINASE
(Homo
sapiens) 		5 / 11 LEU A 368
THR A 365
GLY A 400
ILE A 405
ILE A 390
 None
 1.00A 6gp2B-3e9kA:
undetectable		 6gp2B-3e9kA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3e9k KYNURENINASE
(Homo
sapiens) 		4 / 6 LEU A 403
THR A 365
GLY A 366
ARG A 399
 None
 1.31A 6gtqB-3e9kA:
undetectable
6gtqD-3e9kA:
undetectable		 6gtqB-3e9kA:
18.61
6gtqD-3e9kA:
8.72