SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_A_MTXA351_1
(PTERIDINE REDUCTASE
1)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 SER A1928
PHE A1772
TYR A1930
LEU A1891
PRO A1812
 CL  A2018 ( 4.8A)
None
None
None
None
 1.37A 1p33A-3e9lA:
undetectable		 1p33A-3e9lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_B_MTXB352_1
(PTERIDINE REDUCTASE
1)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 SER A1928
PHE A1772
TYR A1930
LEU A1891
PRO A1812
 CL  A2018 ( 4.8A)
None
None
None
None
 1.40A 1p33B-3e9lA:
undetectable		 1p33B-3e9lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 SER A1928
PHE A1772
TYR A1930
LEU A1891
PRO A1812
 CL  A2018 ( 4.8A)
None
None
None
None
 1.45A 1p33C-3e9lA:
undetectable		 1p33C-3e9lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		4 / 6 ILE A1807
PRO A1858
LEU A1876
ILE A1861
 None
 1.00A 2q83B-3e9lA:
undetectable		 2q83B-3e9lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		4 / 6 SER A1928
PHE A1772
TYR A1930
PRO A1812
 CL  A2018 ( 4.8A)
None
None
None
 1.35A 3jqaA-3e9lA:
undetectable		 3jqaA-3e9lA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		4 / 6 SER A1928
PHE A1772
TYR A1930
PRO A1812
 CL  A2018 ( 4.8A)
None
None
None
 1.37A 3jqaB-3e9lA:
undetectable		 3jqaB-3e9lA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		4 / 6 SER A1928
PHE A1772
TYR A1930
PRO A1812
 CL  A2018 ( 4.8A)
None
None
None
 1.39A 3jqaC-3e9lA:
undetectable		 3jqaC-3e9lA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		4 / 6 SER A1928
PHE A1772
TYR A1930
PRO A1812
 CL  A2018 ( 4.8A)
None
None
None
 1.38A 3jqaD-3e9lA:
undetectable		 3jqaD-3e9lA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		3 / 3 TYR A1768
ARG A2008
SER A1765
 None
 0.93A 4dr2I-3e9lA:
undetectable
4dr2J-3e9lA:
undetectable		 4dr2I-3e9lA:
22.71
4dr2J-3e9lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		3 / 3 TYR A1768
ARG A2008
SER A1765
 None
 1.18A 4lf7I-3e9lA:
undetectable
4lf7J-3e9lA:
undetectable		 4lf7I-3e9lA:
22.71
4lf7J-3e9lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		3 / 3 TYR A1768
ARG A2008
SER A1765
 None
 1.18A 4lf8I-3e9lA:
undetectable
4lf8J-3e9lA:
undetectable		 4lf8I-3e9lA:
22.71
4lf8J-3e9lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 9 LEU A1817
ILE A1809
ILE A1906
PHE A1902
VAL A1899
 None
 1.41A 5igzA-3e9lA:
undetectable		 5igzA-3e9lA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 LEU A1905
PHE A1818
GLN A1816
LEU A1936
ILE A1967
 None
 1.12A 5y2tA-3e9lA:
undetectable		 5y2tA-3e9lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens) 		5 / 12 LEU A1988
ILE A1987
LEU A2012
GLY A2013
ILE A1937
 None
 1.07A 6qyaB-3e9lA:
undetectable		 6qyaB-3e9lA:
22.26