SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e9m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 8 PHE A 164
GLY A 170
LEU A 100
VAL A 310
 None
 1.17A 1gsfA-3e9mA:
undetectable		 1gsfA-3e9mA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 8 PHE A 164
GLY A 170
LEU A 100
VAL A 310
 None
 1.17A 1gsfB-3e9mA:
undetectable		 1gsfB-3e9mA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 8 PHE A 164
GLY A 170
LEU A 100
VAL A 310
 None
 1.17A 1gsfD-3e9mA:
undetectable		 1gsfD-3e9mA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 9 ALA A 122
GLU A 280
ILE A  68
LEU A 288
PHE A 118
 None
 1.31A 3fl9H-3e9mA:
undetectable		 3fl9H-3e9mA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		3 / 3 ILE A 248
SER A 151
SER A 235
 None
 0.63A 3iltH-3e9mA:
undetectable		 3iltH-3e9mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 12 GLU A 168
GLY A 205
VAL A 310
GLY A 171
SER A 166
 None
 1.15A 3k13A-3e9mA:
undetectable		 3k13A-3e9mA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 12 GLU A 168
GLY A 205
VAL A 310
GLY A 171
SER A 166
 None
 1.14A 3k13B-3e9mA:
undetectable		 3k13B-3e9mA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 12 GLU A 168
GLY A 205
VAL A 310
GLY A 171
SER A 166
 None
 1.13A 3k13C-3e9mA:
undetectable		 3k13C-3e9mA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		3 / 3 ILE A  50
VAL A  30
ARG A  23
 None
 0.74A 3p73A-3e9mA:
undetectable		 3p73A-3e9mA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 8 GLN A 132
GLN A 139
ILE A 239
VAL A 149
 None
 0.99A 4dx7B-3e9mA:
undetectable		 4dx7B-3e9mA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 12 VAL A  92
GLY A  77
ILE A  71
SER A  80
LEU A 108
 None
 1.04A 4iv0A-3e9mA:
3.7		 4iv0A-3e9mA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 7 TYR A   6
VAL A  19
ILE A  50
ILE A  33
 None
 0.79A 4lv9A-3e9mA:
undetectable		 4lv9A-3e9mA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 6 GLU A 280
TYR A  70
ILE A  14
TYR A 180
 None
 1.26A 4qwpA-3e9mA:
undetectable		 4qwpA-3e9mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 5 GLU A 280
TYR A  70
ILE A  14
TYR A 180
 None
 1.22A 4qwpB-3e9mA:
undetectable		 4qwpB-3e9mA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA305_0
(THAUMATIN-1)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 5 GLU A  95
ILE A  14
PHE A  18
VAL A  15
 None
 1.37A 4tvtA-3e9mA:
0.0		 4tvtA-3e9mA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		3 / 3 SER A 166
GLU A 311
GLU A 121
 None
 0.74A 4ymgB-3e9mA:
4.2		 4ymgB-3e9mA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 7 PHE A 217
ILE A 193
GLY A 223
MET A 237
 None
 0.76A 4zdzA-3e9mA:
undetectable		 4zdzA-3e9mA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 6 ILE A  71
PRO A  72
ILE A 281
VAL A 284
 None
 0.89A 4zj8A-3e9mA:
7.3		 4zj8A-3e9mA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 12 ALA A 200
GLN A 183
GLY A 178
SER A 179
THR A 306
 None
 1.30A 5hfjB-3e9mA:
2.5		 5hfjB-3e9mA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 11 ALA A 206
VAL A 158
GLY A 170
GLY A 171
ASP A 208
 None
 0.93A 5lf7K-3e9mA:
undetectable
5lf7L-3e9mA:
undetectable		 5lf7K-3e9mA:
19.71
5lf7L-3e9mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 11 ALA A 206
VAL A 158
GLY A 170
GLY A 171
ASP A 208
 None
 0.93A 5lf7Y-3e9mA:
undetectable
5lf7Z-3e9mA:
undetectable		 5lf7Y-3e9mA:
19.71
5lf7Z-3e9mA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		4 / 7 ASP A 208
GLY A 178
GLY A 176
HIS A 175
 None
 0.69A 5n9xA-3e9mA:
3.5		 5n9xA-3e9mA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 11 ALA A  45
SER A  35
VAL A  92
ILE A  71
THR A  73
 None
 1.27A 5y80A-3e9mA:
undetectable		 5y80A-3e9mA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY
(Enterococcus
faecalis) 		5 / 11 ALA A  53
SER A  35
VAL A  92
ILE A  71
THR A  73
 None
 1.23A 5y80A-3e9mA:
undetectable		 5y80A-3e9mA:
14.64