SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 175
LEU A 189
ALA A 151
PHE A 149
GLY A 153
 None
 1.36A 1cmaA-3e9yA:
undetectable
1cmaB-3e9yA:
undetectable		 1cmaA-3e9yA:
11.23
1cmaB-3e9yA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLY A 353
ASN A 358
GLY A 350
VAL A 303
 None
None
FAB  A 701 ( 3.8A)
None
 0.89A 1dbbH-3e9yA:
undetectable
1dbbL-3e9yA:
undetectable		 1dbbH-3e9yA:
17.15
1dbbL-3e9yA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 PRO A 611
THR A 631
PRO A 632
GLY A 633
 None
 0.78A 1h4oB-3e9yA:
undetectable		 1h4oB-3e9yA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 1jffB-3e9yA:
undetectable		 1jffB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 ARG A 583
GLY A 666
ASP A 576
 None
 0.51A 1kf6A-3e9yA:
3.2
1kf6B-3e9yA:
undetectable		 1kf6A-3e9yA:
22.53
1kf6B-3e9yA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ALA A 151
PHE A 149
GLY A 153
LEU A 189
PRO A 249
 None
 1.19A 1mj2A-3e9yA:
undetectable
1mj2B-3e9yA:
undetectable		 1mj2A-3e9yA:
11.40
1mj2B-3e9yA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ALA A 151
PHE A 149
GLY A 153
LEU A 189
PRO A 249
 None
 1.14A 1mj2C-3e9yA:
undetectable
1mj2D-3e9yA:
undetectable		 1mj2C-3e9yA:
11.40
1mj2D-3e9yA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ALA A 151
PHE A 149
GLY A 153
LEU A 189
PRO A 249
 None
 1.16A 1mjoC-3e9yA:
undetectable
1mjoD-3e9yA:
undetectable		 1mjoC-3e9yA:
11.40
1mjoD-3e9yA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 189
PRO A 249
ALA A 151
PHE A 149
GLY A 153
 None
 1.25A 1mjqA-3e9yA:
undetectable
1mjqB-3e9yA:
undetectable		 1mjqA-3e9yA:
11.40
1mjqB-3e9yA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A 189
PRO A 249
ALA A 151
PHE A 149
GLY A 153
 None
 1.22A 1mjqC-3e9yA:
undetectable
1mjqD-3e9yA:
undetectable		 1mjqC-3e9yA:
11.40
1mjqD-3e9yA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 LEU A 189
PRO A 249
ALA A 151
PHE A 149
GLY A 153
 None
 1.25A 1mjqG-3e9yA:
undetectable
1mjqH-3e9yA:
undetectable		 1mjqG-3e9yA:
11.40
1mjqH-3e9yA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 LEU A 189
PRO A 249
ALA A 151
PHE A 149
GLY A 153
 None
 1.22A 1mjqI-3e9yA:
undetectable
1mjqJ-3e9yA:
undetectable		 1mjqI-3e9yA:
11.40
1mjqJ-3e9yA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 PRO A 611
THR A 631
PRO A 632
GLY A 633
 None
 0.78A 1oc3A-3e9yA:
undetectable		 1oc3A-3e9yA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 LEU A 175
PRO A 161
ILE A 192
LEU A 251
 None
 1.10A 1ya4C-3e9yA:
undetectable		 1ya4C-3e9yA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 VAL A 115
GLY A 194
THR A 167
ALA A 166
 None
 0.88A 2a1hA-3e9yA:
undetectable
2a1hB-3e9yA:
undetectable		 2a1hA-3e9yA:
21.75
2a1hB-3e9yA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 112
LEU A 107
VAL A 252
GLY A 162
TYR A 276
 None
None
None
None
NHE  A 696 (-4.7A)
 1.18A 2cbrA-3e9yA:
undetectable		 2cbrA-3e9yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 THR A 379
VAL A 378
LEU A 349
ALA A 386
 None
FAB  A 701 ( 4.7A)
None
None
 0.96A 2e1qC-3e9yA:
undetectable		 2e1qC-3e9yA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 2hxfB-3e9yA:
undetectable		 2hxfB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 2hxhB-3e9yA:
undetectable		 2hxhB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 LEU A 426
PHE A 320
ILE A 296
PHE A 437
 None
 0.96A 2opxA-3e9yA:
undetectable		 2opxA-3e9yA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 ILE A 468
LEU A 471
ASP A 534
ALA A 492
 None
 0.91A 2opxA-3e9yA:
undetectable		 2opxA-3e9yA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 2p4nB-3e9yA:
undetectable		 2p4nB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 ALA A 519
GLY A 178
GLY A 146
ILE A 218
ALA A 182
 None
 1.05A 2plwA-3e9yA:
undetectable		 2plwA-3e9yA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 371
ILE A 396
ASP A 414
VAL A 415
GLY A 334
 FAB  A 701 (-3.5A)
FAB  A 701 (-3.8A)
FAB  A 701 (-4.0A)
FAB  A 701 (-3.8A)
None
 0.84A 2qe6A-3e9yA:
2.2		 2qe6A-3e9yA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 2wbeB-3e9yA:
undetectable		 2wbeB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 VAL A 545
ILE A 521
GLY A 522
ARG A 156
 None
 0.90A 3bjwF-3e9yA:
undetectable		 3bjwF-3e9yA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 VAL A 545
ILE A 521
GLY A 522
ARG A 156
 None
 0.92A 3bjwH-3e9yA:
undetectable		 3bjwH-3e9yA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 3dcoB-3e9yA:
undetectable		 3dcoB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 311
GLY A 307
GLY A 309
THR A 331
LEU A 349
 None
FAB  A 701 (-3.2A)
FAB  A 701 (-3.4A)
FAB  A 701 (-2.9A)
None
 1.41A 3dh0A-3e9yA:
2.7		 3dh0A-3e9yA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 3edlB-3e9yA:
undetectable		 3edlB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 GLN A 573
GLN A 487
GLY A 486
HIS A 488
 None
TDM  A 700 (-4.9A)
TDM  A 700 (-3.4A)
TDM  A 700 (-4.1A)
 1.10A 3huoA-3e9yA:
undetectable		 3huoA-3e9yA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.12A 3iz0B-3e9yA:
undetectable		 3iz0B-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLN A 145
GLY A 146
GLY A 516
GLY A 514
ALA A 519
 None
 1.08A 3kkzB-3e9yA:
undetectable		 3kkzB-3e9yA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 GLY A 325
PHE A 320
GLU A 322
LEU A 435
ILE A 296
 None
 1.21A 3kvrA-3e9yA:
undetectable		 3kvrA-3e9yA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 10 GLY A 325
PHE A 320
GLU A 322
LEU A 435
ILE A 296
 None
 1.25A 3kvrB-3e9yA:
undetectable		 3kvrB-3e9yA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 4 GLY A 318
GLU A 322
ASP A 342
ASP A 315
 None
 1.42A 3mb5A-3e9yA:
4.4		 3mb5A-3e9yA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 ILE A 234
ILE A 235
VAL A 225
ILE A 192
 None
 0.85A 3p4wC-3e9yA:
undetectable		 3p4wC-3e9yA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 VAL A 361
TYR A 305
LEU A 367
VAL A 378
GLY A 380
 None
None
None
FAB  A 701 ( 4.7A)
None
 1.21A 3pghB-3e9yA:
undetectable		 3pghB-3e9yA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 522
GLY A 162
ALA A 155
ALA A 182
ASP A 185
 None
None
None
None
FAB  A 701 ( 4.8A)
 1.03A 3sudD-3e9yA:
undetectable		 3sudD-3e9yA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 522
GLY A 162
ALA A 155
ALA A 182
ASP A 185
 None
None
None
None
FAB  A 701 ( 4.8A)
 0.94A 3sugA-3e9yA:
undetectable		 3sugA-3e9yA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 ASP A 376
GLY A 655
THR A 656
ILE A 651
 1MS  A 695 (-3.5A)
None
None
None
 0.88A 4acaC-3e9yA:
2.8		 4acaC-3e9yA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 TYR A 498
VAL A 533
VAL A 558
ILE A 480
 None
 1.12A 4aftD-3e9yA:
undetectable
4aftE-3e9yA:
undetectable		 4aftD-3e9yA:
19.43
4aftE-3e9yA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 VAL A 532
ASN A 527
PRO A 528
ILE A 521
 None
 1.10A 4iilA-3e9yA:
4.4		 4iilA-3e9yA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 PRO A 141
ASN A 138
HIS A 127
 None
 0.78A 4ma3H-3e9yA:
undetectable
4ma3L-3e9yA:
undetectable		 4ma3H-3e9yA:
17.70
4ma3L-3e9yA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLY A 514
PHE A 149
SER A 177
ASN A 544
 None
 1.01A 4wryA-3e9yA:
undetectable		 4wryA-3e9yA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLY A 514
PHE A 149
SER A 177
ASN A 544
 None
 0.97A 4wrzA-3e9yA:
undetectable		 4wrzA-3e9yA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 8 GLY A 514
PHE A 149
SER A 177
ASN A 544
 None
 0.97A 4ws1A-3e9yA:
undetectable		 4ws1A-3e9yA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 6 LEU A 183
TRP A 504
GLN A 489
MET A 333
 None
None
FAB  A 701 (-3.5A)
FAB  A 701 (-4.0A)
 1.47A 5h8tA-3e9yA:
undetectable		 5h8tA-3e9yA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 5 HIS A 352
LEU A 568
TYR A 579
PHE A 578
 None
TDM  A 700 (-3.8A)
None
None
 1.43A 5igjA-3e9yA:
undetectable		 5igjA-3e9yA:
19.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		3 / 3 GLY A 121
GLN A 207
LYS A 256
 None
 0.60A 5imsB-3e9yA:
51.3		 5imsB-3e9yA:
39.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		6 / 12 VAL A 532
SER A 524
GLY A 516
ALA A 519
SER A 482
LEU A 505
 None
 1.46A 5kirB-3e9yA:
0.0		 5kirB-3e9yA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_V_6V8V303_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 11 THR A 193
ALA A 191
CYH A 164
ALA A 172
LEU A 184
 None
 1.12A 5lf7V-3e9yA:
undetectable
5lf7W-3e9yA:
undetectable		 5lf7V-3e9yA:
18.45
5lf7W-3e9yA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 VAL A 533
ASP A 534
LEU A 621
ARG A 614
GLY A 537
 None
None
None
None
TDM  A 700 (-3.6A)
 1.11A 5ogcB-3e9yA:
undetectable		 5ogcB-3e9yA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 LEU A 561
THR A 475
ILE A 531
LEU A 629
 None
 0.92A 5te8C-3e9yA:
undetectable		 5te8C-3e9yA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		4 / 7 GLU A 554
ALA A 150
GLY A 522
TYR A 154
 None
 1.01A 5uxdA-3e9yA:
undetectable		 5uxdA-3e9yA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 LEU A 561
ILE A 468
LEU A 335
ILE A 481
HIS A 347
 None
 1.21A 5y2tB-3e9yA:
undetectable		 5y2tB-3e9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 371
ASP A 395
ILE A 396
ASP A 397
ASP A 414
 FAB  A 701 (-3.5A)
FAB  A 701 (-3.0A)
FAB  A 701 (-3.8A)
None
FAB  A 701 (-4.0A)
 0.57A 6bq4A-3e9yA:
3.7		 6bq4A-3e9yA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 371
ASP A 395
ILE A 396
ASP A 397
ASP A 414
 FAB  A 701 (-3.5A)
FAB  A 701 (-3.0A)
FAB  A 701 (-3.8A)
None
FAB  A 701 (-4.0A)
 0.59A 6bq4B-3e9yA:
3.7		 6bq4B-3e9yA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 153
GLY A 522
VAL A 525
VAL A 139
PRO A 141
 None
 1.02A 6gneA-3e9yA:
undetectable		 6gneA-3e9yA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC
(Arabidopsis
thaliana) 		5 / 12 GLY A 153
GLY A 522
VAL A 525
VAL A 139
PRO A 141
 None
 1.02A 6gneB-3e9yA:
3.5		 6gneB-3e9yA:
21.75