SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3e9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 SER A 116
VAL A 115
TYR A  52
MET A 105
 None
 0.94A 1fduB-3e9zA:
undetectable		 1fduB-3e9zA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 LEU A  70
LEU A 108
PRO A  27
HIS A  17
ALA A  16
 None
 1.30A 1mjqA-3e9zA:
undetectable
1mjqB-3e9zA:
undetectable		 1mjqA-3e9zA:
16.73
1mjqB-3e9zA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 11 LEU A  70
LEU A 108
PRO A  27
HIS A  17
ALA A  16
 None
 1.31A 1mjqI-3e9zA:
undetectable
1mjqJ-3e9zA:
undetectable		 1mjqI-3e9zA:
16.73
1mjqJ-3e9zA:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 10 GLY A 120
GLU A 203
VAL A 219
GLY A 220
MET A 221
THR A 244
ASN A 245
HIS A 259
 6GU  A 704 (-2.9A)
6GU  A 704 (-2.4A)
6GU  A 704 ( 4.3A)
6GU  A 704 (-3.4A)
6GU  A 704 (-3.7A)
6GU  A 704 (-3.7A)
6GU  A 704 (-2.7A)
None
 0.61A 1pwyE-3e9zA:
41.0		 1pwyE-3e9zA:
48.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 ILE A 133
ILE A 112
VAL A 237
ILE A 280
ILE A  29
 None
 1.28A 1r5lA-3e9zA:
undetectable		 1r5lA-3e9zA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 10 GLY A 120
GLU A 203
VAL A 219
GLY A 220
MET A 221
THR A 244
ASN A 245
HIS A 259
 6GU  A 704 (-2.9A)
6GU  A 704 (-2.4A)
6GU  A 704 ( 4.3A)
6GU  A 704 (-3.4A)
6GU  A 704 (-3.7A)
6GU  A 704 (-3.7A)
6GU  A 704 (-2.7A)
None
 0.51A 1v3qE-3e9zA:
41.2		 1v3qE-3e9zA:
48.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 SER A 125
ASN A 123
VAL A 177
ALA A 180
VAL A 240
 None
 1.09A 2nniA-3e9zA:
undetectable		 2nniA-3e9zA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		3 / 3 LEU A 212
ASN A 123
ARG A 124
 None
 0.93A 2qhfA-3e9zA:
undetectable		 2qhfA-3e9zA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 PHE A 238
ALA A  41
ALA A 176
ALA A 180
LEU A 272
 None
 1.07A 2x2nB-3e9zA:
undetectable		 2x2nB-3e9zA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 LEU A  40
ILE A 281
LEU A 284
ILE A  31
VAL A 240
 None
 1.08A 2ygpA-3e9zA:
undetectable		 2ygpA-3e9zA:
20.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		6 / 6 GLY A 120
TYR A 202
GLU A 203
GLY A 220
MET A 221
ASN A 245
 6GU  A 704 (-2.9A)
6GU  A 704 (-4.8A)
6GU  A 704 (-2.4A)
6GU  A 704 (-3.4A)
6GU  A 704 (-3.7A)
6GU  A 704 (-2.7A)
 0.28A 3e9rA-3e9zA:
48.5		 3e9rA-3e9zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		6 / 6 GLY A 120
TYR A 202
GLU A 203
GLY A 220
MET A 221
ASN A 245
 6GU  A 704 (-2.9A)
6GU  A 704 (-4.8A)
6GU  A 704 (-2.4A)
6GU  A 704 (-3.4A)
6GU  A 704 (-3.7A)
6GU  A 704 (-2.7A)
 0.32A 3e9rC-3e9zA:
48.2		 3e9rC-3e9zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 12 SER A  35
ALA A 118
GLY A 120
GLU A 203
VAL A 219
GLY A 220
ASN A 245
VAL A 262
 None
6GU  A 704 ( 3.5A)
6GU  A 704 (-2.9A)
6GU  A 704 (-2.4A)
6GU  A 704 ( 4.3A)
6GU  A 704 (-3.4A)
6GU  A 704 (-2.7A)
6GU  A 704 ( 4.3A)
 1.46A 3f8wA-3e9zA:
46.5		 3f8wA-3e9zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		11 / 12 TYR A  90
ALA A 118
GLY A 120
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
HIS A 259
VAL A 262
 None
6GU  A 704 ( 3.5A)
6GU  A 704 (-2.9A)
6GU  A 704 (-4.8A)
6GU  A 704 (-2.4A)
6GU  A 704 ( 4.3A)
6GU  A 704 (-3.4A)
6GU  A 704 (-3.7A)
6GU  A 704 (-2.7A)
None
6GU  A 704 ( 4.3A)
 0.42A 3f8wA-3e9zA:
46.5		 3f8wA-3e9zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		11 / 12 HIS A  88
TYR A  90
GLY A 120
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
HIS A 259
VAL A 262
 SO4  A 291 (-3.9A)
None
6GU  A 704 (-2.9A)
6GU  A 704 (-4.8A)
6GU  A 704 (-2.4A)
6GU  A 704 ( 4.3A)
6GU  A 704 (-3.4A)
6GU  A 704 (-3.7A)
6GU  A 704 (-2.7A)
None
6GU  A 704 ( 4.3A)
 0.42A 3f8wB-3e9zA:
46.0		 3f8wB-3e9zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		7 / 12 SER A  35
GLY A 120
GLU A 203
VAL A 219
GLY A 220
ASN A 245
VAL A 262
 None
6GU  A 704 (-2.9A)
6GU  A 704 (-2.4A)
6GU  A 704 ( 4.3A)
6GU  A 704 (-3.4A)
6GU  A 704 (-2.7A)
6GU  A 704 ( 4.3A)
 1.33A 3f8wB-3e9zA:
46.0		 3f8wB-3e9zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		11 / 12 HIS A  88
TYR A  90
ALA A 118
GLY A 120
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
VAL A 262
 SO4  A 291 (-3.9A)
None
6GU  A 704 ( 3.5A)
6GU  A 704 (-2.9A)
6GU  A 704 (-4.8A)
6GU  A 704 (-2.4A)
6GU  A 704 ( 4.3A)
6GU  A 704 (-3.4A)
6GU  A 704 (-3.7A)
6GU  A 704 (-2.7A)
6GU  A 704 ( 4.3A)
 0.33A 3f8wC-3e9zA:
46.3		 3f8wC-3e9zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 12 SER A  35
ALA A 118
GLY A 120
GLU A 203
VAL A 219
GLY A 220
ASN A 245
VAL A 262
 None
6GU  A 704 ( 3.5A)
6GU  A 704 (-2.9A)
6GU  A 704 (-2.4A)
6GU  A 704 ( 4.3A)
6GU  A 704 (-3.4A)
6GU  A 704 (-2.7A)
6GU  A 704 ( 4.3A)
 1.46A 3f8wC-3e9zA:
46.3		 3f8wC-3e9zA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 6 THR A 223
ASN A 117
GLY A  34
ILE A  31
 None
None
SO4  A 291 (-3.0A)
None
 1.02A 3w9tF-3e9zA:
undetectable		 3w9tF-3e9zA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 4 VAL A 243
LEU A 188
ASN A 123
ASP A 217
 None
 1.39A 5vcyA-3e9zA:
undetectable		 5vcyA-3e9zA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 LEU A  40
ILE A 280
PHE A 185
VAL A 189
LEU A 113
 None
 1.27A 6djzB-3e9zA:
undetectable		 6djzB-3e9zA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 3e9z PURINE-NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 THR A 223
ILE A 224
LEU A 134
ASP A 217
LEU A 122
 None
 1.21A 6ie8A-3e9zA:
undetectable		 6ie8A-3e9zA:
20.21