SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ea0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 8 PHE A 123
ILE A  39
LEU A 138
VAL A 121
 None
 0.89A 1fslA-3ea0A:
undetectable		 1fslA-3ea0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 8 PHE A 123
ILE A  39
LEU A 138
VAL A 121
 None
 0.88A 1fslB-3ea0A:
undetectable		 1fslB-3ea0A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		5 / 12 ASP A 205
ASP A 180
ARG A 178
ILE A 202
ILE A 232
 None
None
ATP  A 243 (-3.1A)
None
None
 1.18A 1kijA-3ea0A:
undetectable		 1kijA-3ea0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		5 / 12 ILE A 120
GLY A  15
GLU A 140
PHE A   4
ASN A  21
 None
ATP  A 243 (-3.8A)
None
None
None
 1.21A 1sg9A-3ea0A:
3.1		 1sg9A-3ea0A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		3 / 3 ASP A 234
GLU A 173
TYR A 118
 None
 0.86A 1wsvA-3ea0A:
undetectable		 1wsvA-3ea0A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 7 SER A 212
ALA A 223
LEU A 220
SER A 218
 None
 0.91A 3cfqA-3ea0A:
undetectable
3cfqB-3ea0A:
undetectable		 3cfqA-3ea0A:
17.93
3cfqB-3ea0A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 6 ILE A 111
TYR A 116
MET A  77
ILE A  62
 None
 1.17A 3eteA-3ea0A:
undetectable
3eteE-3ea0A:
undetectable		 3eteA-3ea0A:
20.24
3eteE-3ea0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 5 ILE A 111
TYR A 116
MET A  77
ILE A  62
 None
 1.20A 3eteB-3ea0A:
undetectable
3eteC-3ea0A:
undetectable		 3eteB-3ea0A:
20.24
3eteC-3ea0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		5 / 9 PHE A   6
ASN A  21
PHE A  22
ALA A  23
LEU A  46
 None
 1.49A 3t3sA-3ea0A:
0.0		 3t3sA-3ea0A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 6 GLY A  15
VAL A 144
GLY A   5
GLU A 140
 ATP  A 243 (-3.8A)
None
None
None
 0.86A 4dxuA-3ea0A:
undetectable		 4dxuA-3ea0A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 7 ALA A 223
LEU A 220
SER A 218
SER A 212
 None
 1.02A 4ikjA-3ea0A:
undetectable
4ikjB-3ea0A:
undetectable		 4ikjA-3ea0A:
21.07
4ikjB-3ea0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 7 SER A 212
ALA A 223
LEU A 220
SER A 218
 None
 0.94A 4ikkA-3ea0A:
undetectable
4ikkB-3ea0A:
undetectable		 4ikkA-3ea0A:
21.07
4ikkB-3ea0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 7 ALA A 223
LEU A 220
SER A 218
SER A 212
 None
 0.92A 4iklA-3ea0A:
undetectable
4iklB-3ea0A:
undetectable		 4iklA-3ea0A:
21.07
4iklB-3ea0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		4 / 8 SER A 212
ALA A 223
LEU A 220
SER A 218
 None
 0.92A 4iklA-3ea0A:
undetectable
4iklB-3ea0A:
undetectable		 4iklA-3ea0A:
21.07
4iklB-3ea0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		5 / 12 ILE A 232
THR A 231
ALA A 179
LEU A 228
ASP A 180
 None
None
None
ATP  A 243 ( 4.6A)
None
 1.48A 4pbhA-3ea0A:
1.6		 4pbhA-3ea0A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 3ea0 ATPASE, PARA FAMILY
(Chlorobaculum
tepidum) 		5 / 12 PRO A  91
ASP A  58
LEU A  59
VAL A  98
SER A  63
 None
 1.41A 6b50A-3ea0A:
2.7		 6b50A-3ea0A:
23.91