SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		4 / 8 ILE A  48
LEU A  46
ALA A  21
VAL A  28
 None
 0.60A 1a29A-3eagA:
undetectable		 1a29A-3eagA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 12 THR A 154
ALA A 133
GLU A 128
LEU A 132
ILE A  20
 None
 1.16A 1errA-3eagA:
undetectable		 1errA-3eagA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 12 THR A 154
ALA A 133
GLU A 128
LEU A 132
ILE A  20
 None
 1.21A 1errB-3eagA:
undetectable		 1errB-3eagA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 10 MET A 292
LEU A 295
GLU A 250
LEU A 273
ARG A 302
 None
 1.46A 1pcgB-3eagA:
undetectable		 1pcgB-3eagA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		3 / 3 LEU A  88
HIS A   5
ILE A   7
 None
 0.61A 1s9pB-3eagA:
undetectable		 1s9pB-3eagA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		4 / 7 ARG A 188
SER A  98
GLN A  95
GLU A  99
 None
None
GOL  A 401 (-4.1A)
None
 1.15A 2c8aA-3eagA:
undetectable		 2c8aA-3eagA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 11 ARG A 233
ARG A 288
GLY A 257
TRP A 258
THR A 277
 None
 1.32A 3ag1G-3eagA:
undetectable
3ag1N-3eagA:
undetectable
3ag1O-3eagA:
undetectable		 3ag1G-3eagA:
13.46
3ag1N-3eagA:
23.18
3ag1O-3eagA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		3 / 3 GLU A  61
PHE A  62
GLN A  58
 None
 0.91A 3r55A-3eagA:
undetectable		 3r55A-3eagA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 12 LEU A 315
VAL A 126
THR A 119
PHE A 252
GLY A 112
 None
 1.26A 4q15A-3eagA:
2.6		 4q15A-3eagA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 12 LEU A 315
VAL A 126
THR A 119
PHE A 252
GLY A 112
 None
 1.25A 4q15B-3eagA:
2.9		 4q15B-3eagA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 9 ALA A 311
THR A 310
ALA A 314
GLY A 305
ALA A 301
 None
 1.10A 4qvnK-3eagA:
undetectable
4qvnL-3eagA:
undetectable		 4qvnK-3eagA:
21.82
4qvnL-3eagA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 9 ALA A 311
THR A 310
ALA A 314
GLY A 305
ALA A 301
 None
 1.10A 4qvnY-3eagA:
undetectable
4qvnZ-3eagA:
undetectable		 4qvnY-3eagA:
21.82
4qvnZ-3eagA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 9 ALA A 311
THR A 310
ALA A 314
GLY A 305
ALA A 301
 None
 1.11A 4qvqK-3eagA:
undetectable
4qvqL-3eagA:
undetectable		 4qvqK-3eagA:
21.43
4qvqL-3eagA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 9 ALA A 311
THR A 310
ALA A 314
GLY A 305
ALA A 301
 None
 1.10A 4qvqY-3eagA:
undetectable
4qvqZ-3eagA:
undetectable		 4qvqY-3eagA:
21.43
4qvqZ-3eagA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		4 / 8 ILE A  48
LEU A  46
ALA A  21
VAL A  28
 None
 0.70A 4rjdA-3eagA:
undetectable		 4rjdA-3eagA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		4 / 4 ILE A 298
ILE A 308
ARG A 302
LEU A 295
 None
 1.26A 5dzkh-3eagA:
undetectable
5dzkn-3eagA:
undetectable
5dzkv-3eagA:
undetectable		 5dzkh-3eagA:
21.10
5dzkn-3eagA:
21.10
5dzkv-3eagA:
0.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		4 / 5 GLY A  16
PRO A  38
THR A  12
GLN A  42
 None
 1.30A 5h5fA-3eagA:
4.4		 5h5fA-3eagA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND4_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 12 VAL A 229
GLU A 250
LEU A 108
ALA A 300
ARG A 302
 None
 1.11A 5nd4B-3eagA:
3.0		 5nd4B-3eagA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 11 ARG A 233
ARG A 288
GLY A 257
TRP A 258
THR A 277
 None
 1.32A 5w97G-3eagA:
undetectable
5w97a-3eagA:
undetectable
5w97b-3eagA:
undetectable		 5w97G-3eagA:
13.46
5w97a-3eagA:
23.18
5w97b-3eagA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 11 GLY A 257
TRP A 258
THR A 277
ARG A 233
ARG A 288
 None
 1.36A 5w97A-3eagA:
undetectable
5w97B-3eagA:
undetectable
5w97g-3eagA:
undetectable		 5w97A-3eagA:
23.18
5w97B-3eagA:
21.26
5w97g-3eagA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 12 LEU A 315
VAL A 126
THR A 119
PHE A 252
GLY A 112
 None
 1.22A 5xipC-3eagA:
3.0		 5xipC-3eagA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		3 / 3 THR A 119
GLU A 172
ASN A 195
 None
 0.85A 6nj9K-3eagA:
2.9		 6nj9K-3eagA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 11 GLY A 257
TRP A 258
THR A 277
ARG A 233
ARG A 288
 None
 1.35A 6nknA-3eagA:
undetectable
6nknB-3eagA:
undetectable
6nknT-3eagA:
undetectable		 6nknA-3eagA:
23.18
6nknB-3eagA:
21.26
6nknT-3eagA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 9 ARG A 233
ARG A 288
GLY A 257
TRP A 258
THR A 277
 None
 1.35A 6nknG-3eagA:
0.0
6nknN-3eagA:
0.0
6nknO-3eagA:
0.0		 6nknG-3eagA:
13.46
6nknN-3eagA:
23.18
6nknO-3eagA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3eag UDP-N-ACETYLMURAMATE
:L-ALANYL-GAMMA-D-GL
UTAMYL-MESO-DIAMINOP
IMELATE LIGASE
(Neisseria
meningitidis) 		5 / 10 ARG A 233
ARG A 288
GLY A 257
TRP A 258
THR A 277
 None
 1.32A 6nmfG-3eagA:
0.0
6nmfN-3eagA:
0.0
6nmfO-3eagA:
0.0		 6nmfG-3eagA:
13.46
6nmfN-3eagA:
23.18
6nmfO-3eagA:
21.26