SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eap'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.16A 1a28B-3eapA:
undetectable		 1a28B-3eapA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		4 / 8 PHE A  47
ILE A  46
LEU A 120
VAL A 102
 None
 0.86A 1fslA-3eapA:
undetectable		 1fslA-3eapA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_A_CCSA47_0
(GLUTATHIONE
S-TRANSFERASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		4 / 7 LEU A 231
THR A 156
LEU A 158
LEU A 163
 None
 0.91A 1gtiA-3eapA:
undetectable		 1gtiA-3eapA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 11 ASN A 153
ARG A 172
SER A 160
GLY A 239
ARG A 240
 None
 1.35A 1ho5A-3eapA:
undetectable		 1ho5A-3eapA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.18A 1sqnA-3eapA:
undetectable		 1sqnA-3eapA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.11A 1sqnB-3eapA:
undetectable		 1sqnB-3eapA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.18A 2w8yB-3eapA:
undetectable		 2w8yB-3eapA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.21A 3d90A-3eapA:
undetectable		 3d90A-3eapA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 LEU A  15
LEU A  12
LEU A   9
LEU A 137
CYH A 161
 None
 1.18A 3d90B-3eapA:
undetectable		 3d90B-3eapA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 PHE A  68
LEU A  95
LEU A  98
PHE A  47
ILE A 117
 None
 1.19A 3lbdA-3eapA:
undetectable		 3lbdA-3eapA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		3 / 3 GLY A   0
TRP A   2
VAL A   7
 None
 0.72A 3n62B-3eapA:
undetectable		 3n62B-3eapA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		3 / 3 GLY A   0
TRP A   2
VAL A   7
 None
 0.75A 3n65B-3eapA:
undetectable		 3n65B-3eapA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		3 / 3 GLY A   0
TRP A   2
VAL A   7
 None
 0.73A 3n66B-3eapA:
undetectable		 3n66B-3eapA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 LEU A  15
VAL A  23
ALA A 140
ALA A 155
THR A 156
 None
 1.10A 4fiaA-3eapA:
undetectable		 4fiaA-3eapA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 PHE A 244
LEU A  15
ALA A 140
ALA A 155
THR A 156
 None
 1.23A 4fiaA-3eapA:
undetectable		 4fiaA-3eapA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 LEU A  15
VAL A  23
ALA A 140
ALA A 155
THR A 156
 None
 1.10A 4fiaA-3eapA:
undetectable		 4fiaA-3eapA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 12 PHE A 244
LEU A  15
ALA A 140
ALA A 155
THR A 156
 None
 1.23A 4fiaA-3eapA:
undetectable		 4fiaA-3eapA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		5 / 11 LEU A 159
LEU A 204
HIS A 138
LEU A 142
ALA A 140
 None
 1.15A 4p65B-3eapA:
undetectable
4p65D-3eapA:
undetectable
4p65G-3eapA:
undetectable
4p65H-3eapA:
undetectable		 4p65B-3eapA:
7.84
4p65D-3eapA:
7.84
4p65G-3eapA:
8.57
4p65H-3eapA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		3 / 3 GLY A   0
TRP A   2
VAL A   7
 None
 0.76A 5vuoB-3eapA:
undetectable		 5vuoB-3eapA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3eap RHO
GTPASE-ACTIVATING
PROTEIN 11A
(Homo
sapiens) 		4 / 7 ALA A 118
ILE A 232
LEU A 195
ILE A 132
 None
None
None
UNX  A 254 (-4.5A)
 0.86A 6b5vA-3eapA:
undetectable
6b5vB-3eapA:
undetectable		 6b5vA-3eapA:
15.72
6b5vB-3eapA:
15.72