SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ear'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 3ear HERA
(Thermus
thermophilus) 		5 / 12 MET A 242
LEU A 292
GLU A 252
LEU A 272
ILE A 304
 None
 1.07A 3olsB-3earA:
undetectable		 3olsB-3earA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3ear HERA
(Thermus
thermophilus) 		3 / 3 TYR A 213
ARG A 359
LYS A 211
 None
 1.45A 4wq5B-3earA:
undetectable		 4wq5B-3earA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3ear HERA
(Thermus
thermophilus) 		3 / 3 VAL A 235
GLU A 214
GLU A 216
 None
 0.76A 5jsdB-3earA:
undetectable
5jsdC-3earA:
undetectable		 5jsdB-3earA:
13.26
5jsdC-3earA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 3ear HERA
(Thermus
thermophilus) 		5 / 10 PRO A 367
LEU A 232
VAL A 372
SER A 230
GLU A 227
 None
 1.30A 5tixB-3earA:
undetectable		 5tixB-3earA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 3ear HERA
(Thermus
thermophilus) 		4 / 4 HIS A 269
VAL A 280
LEU A 272
ALA A 267
 None
 0.93A 6d8pB-3earA:
undetectable		 6d8pB-3earA:
15.34