SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		5 / 10 LYS A 681
VAL A 696
TYR A 685
GLY A 695
LEU A 974
 None
 1.37A 1fk9A-3eayA:
undetectable		 1fk9A-3eayA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		5 / 10 LYS A 681
VAL A 696
TYR A 685
GLY A 695
LEU A 974
 None
 1.38A 1ikwA-3eayA:
1.7		 1ikwA-3eayA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		4 / 5 ILE A 737
PHE A 937
PRO A 788
VAL A 809
 None
 0.95A 2ygnA-3eayA:
undetectable		 2ygnA-3eayA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		5 / 12 LEU A 701
ILE A 737
LEU A 694
VAL A 713
VAL A 696
 None
 1.13A 3gwxB-3eayA:
undetectable		 3gwxB-3eayA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		5 / 9 LYS A 681
VAL A 696
TYR A 685
GLY A 695
LEU A 974
 None
 1.36A 4b3oA-3eayA:
undetectable		 4b3oA-3eayA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		5 / 12 LEU A 719
ILE A 967
TYR A 718
GLY A 927
PHE A 938
 None
 1.13A 5eskA-3eayA:
undetectable		 5eskA-3eayA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		3 / 3 PRO A 788
LEU A 722
SER A 739
 None
 0.82A 5fsaB-3eayA:
undetectable		 5fsaB-3eayA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		4 / 6 ILE A 949
ILE A 785
PHE A 937
PHE A 780
 None
 0.93A 5vkqA-3eayA:
undetectable
5vkqB-3eayA:
undetectable		 5vkqA-3eayA:
11.19
5vkqB-3eayA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		4 / 6 ILE A 949
ILE A 785
PHE A 937
PHE A 780
 None
 0.89A 5vkqB-3eayA:
undetectable
5vkqC-3eayA:
undetectable		 5vkqB-3eayA:
11.19
5vkqC-3eayA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		4 / 6 ILE A 949
ILE A 785
PHE A 937
PHE A 780
 None
 0.94A 5vkqC-3eayA:
undetectable
5vkqD-3eayA:
undetectable		 5vkqC-3eayA:
11.19
5vkqD-3eayA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		4 / 6 PHE A 780
ILE A 949
ILE A 785
PHE A 937
 None
 0.92A 5vkqA-3eayA:
undetectable
5vkqD-3eayA:
undetectable		 5vkqA-3eayA:
11.19
5vkqD-3eayA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3eay SENTRIN-SPECIFIC
PROTEASE 7
(Homo
sapiens) 		5 / 10 LYS A 681
VAL A 696
TYR A 685
GLY A 695
LEU A 974
 None
 1.35A 6bsiA-3eayA:
undetectable		 6bsiA-3eayA:
13.31