SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eb8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		5 / 12 ILE A 353
GLY A 357
GLY A 143
PRO A 150
ALA A 151
 None
 1.09A 1nv8A-3eb8A:
undetectable		 1nv8A-3eb8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		5 / 12 ILE A 353
GLY A 357
GLY A 143
PRO A 150
ALA A 151
 None
 1.06A 1nv8B-3eb8A:
undetectable		 1nv8B-3eb8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		5 / 12 ILE A 353
GLY A 357
GLY A 143
PRO A 150
ALA A 151
 None
 1.03A 1sg9B-3eb8A:
undetectable		 1sg9B-3eb8A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		5 / 12 ILE A 353
GLY A 357
GLY A 143
PRO A 150
ALA A 151
 None
 1.03A 1vq1B-3eb8A:
undetectable		 1vq1B-3eb8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		4 / 8 GLY A 372
THR A 373
ALA A 269
VAL A 326
 None
 0.74A 2a1hA-3eb8A:
undetectable
2a1hB-3eb8A:
undetectable		 2a1hA-3eb8A:
20.47
2a1hB-3eb8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		4 / 8 VAL A 326
GLY A 372
THR A 373
ALA A 269
 None
 0.76A 2a1hA-3eb8A:
undetectable
2a1hB-3eb8A:
undetectable		 2a1hA-3eb8A:
20.47
2a1hB-3eb8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		3 / 3 ILE A 166
ILE A 363
LEU A  69
 None
 0.54A 2prgA-3eb8A:
undetectable		 2prgA-3eb8A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1469_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		4 / 4 GLN A 238
GLU A 218
LEU A 234
SER A 235
 None
 1.39A 2xrzA-3eb8A:
0.0		 2xrzA-3eb8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		5 / 12 LEU A 374
ILE A 186
ILE A 216
VAL A 344
VAL A 369
 None
 1.06A 2ygnA-3eb8A:
undetectable		 2ygnA-3eb8A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		4 / 7 ILE A 395
HIS A 135
LYS A 133
ILE A 292
 None
 0.79A 3eteD-3eb8A:
undetectable
3eteF-3eb8A:
undetectable		 3eteD-3eb8A:
21.63
3eteF-3eb8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		4 / 7 ILE A 395
HIS A 135
LYS A 133
TYR A 293
 None
 0.91A 3eteD-3eb8A:
undetectable
3eteF-3eb8A:
undetectable		 3eteD-3eb8A:
21.63
3eteF-3eb8A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		4 / 5 ASN A 316
THR A 365
SER A 346
SER A 276
 None
 1.37A 3hlwB-3eb8A:
undetectable		 3hlwB-3eb8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		3 / 3 SER A 346
ASP A 214
ASP A 189
 None
 0.75A 4uckA-3eb8A:
undetectable		 4uckA-3eb8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		5 / 12 VAL A 154
GLY A 357
HIS A 352
ILE A 395
ILE A 396
 None
 0.93A 4xdrA-3eb8A:
undetectable		 4xdrA-3eb8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		3 / 3 ASP A 214
ASN A 244
PHE A 254
 None
 0.77A 5dsgB-3eb8A:
undetectable		 5dsgB-3eb8A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		3 / 3 PRO A 125
ILE A 321
SER A  64
 None
 0.63A 5fsaA-3eb8A:
undetectable		 5fsaA-3eb8A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6L_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3eb8 CYSTEINE
PROTEASE-LIKE VIRA
(Shigella
flexneri) 		5 / 9 ALA A 269
ASP A 267
LEU A 264
ILE A 200
PRO A 208
 None
 1.48A 5z6lA-3eb8A:
undetectable		 5z6lA-3eb8A:
16.16