SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ebb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 705
LEU A 702
ALA A 701
LEU A 647
MET A 676
 None
 1.00A 2aa6A-3ebbA:
undetectable		 2aa6A-3ebbA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.18A 2eimJ-3ebbA:
undetectable		 2eimJ-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 647
ILE A 698
ALA A 701
GLU A 734
LEU A 728
 None
 1.29A 2v0mB-3ebbA:
undetectable		 2v0mB-3ebbA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.13A 3ag1J-3ebbA:
undetectable		 3ag1J-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 6 ILE A 644
ARG A 680
MET A 676
LEU A 675
 None
 0.93A 3ag1N-3ebbA:
2.2
3ag1W-3ebbA:
undetectable		 3ag1N-3ebbA:
19.27
3ag1W-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		3 / 3 PHE A 667
CYH A 712
PHE A 713
 None
 1.14A 3cr5X-3ebbA:
undetectable		 3cr5X-3ebbA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		3 / 3 CYH A 631
PHE A 630
PHE A 639
 None
 0.83A 3cr5X-3ebbA:
undetectable		 3cr5X-3ebbA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		3 / 3 ASN A 697
HIS A 699
VAL A 736
 None
 0.67A 3elzB-3ebbA:
undetectable		 3elzB-3ebbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 8 TYR A 775
SER A 770
SER A 730
LEU A 733
 None
 1.03A 3lsfH-3ebbA:
undetectable		 3lsfH-3ebbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		3 / 3 PRO A 591
THR A 592
LEU A 575
 None
 0.77A 3ttrA-3ebbA:
undetectable		 3ttrA-3ebbA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 749
LEU A 745
LEU A 728
SER A 727
 None
 1.03A 3vhuA-3ebbA:
undetectable		 3vhuA-3ebbA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 551
ALA A 546
ILE A 583
THR A 662
LEU A 599
 None
 1.06A 4cd2A-3ebbA:
undetectable		 4cd2A-3ebbA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 705
LEU A 702
ALA A 701
ALA A 659
MET A 676
 None
 1.12A 4fn9A-3ebbA:
undetectable		 4fn9A-3ebbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 555
LEU A 614
LEU A 576
ASN A 655
 None
 1.00A 4n09B-3ebbA:
undetectable		 4n09B-3ebbA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 599
LEU A 552
ILE A 551
LEU A 555
PRO A 591
 None
 0.92A 4odrA-3ebbA:
undetectable
4odrB-3ebbA:
undetectable		 4odrA-3ebbA:
15.89
4odrB-3ebbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		5 / 11 PRO A 591
LEU A 599
LEU A 552
ILE A 551
LEU A 555
 None
 0.90A 4odrA-3ebbA:
undetectable
4odrB-3ebbA:
undetectable		 4odrA-3ebbA:
15.89
4odrB-3ebbA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		5 / 11 ALA A 748
GLY A 750
VAL A 541
LYS A 537
PHE A 743
 None
 1.12A 4zmeA-3ebbA:
undetectable		 4zmeA-3ebbA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 8 THR A 731
SER A 692
SER A 694
ALA A 687
 None
 1.11A 5l5fY-3ebbA:
undetectable
5l5fZ-3ebbA:
undetectable		 5l5fY-3ebbA:
21.64
5l5fZ-3ebbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 6 THR A 704
ASN A 708
ARG A 744
GLU A 539
 None
 1.06A 5uigA-3ebbA:
undetectable		 5uigA-3ebbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.15A 5wauJ-3ebbA:
undetectable		 5wauJ-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.19A 5x19J-3ebbA:
undetectable		 5x19J-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.21A 5x1bJ-3ebbA:
undetectable		 5x1bJ-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.23A 5x1bW-3ebbA:
undetectable		 5x1bW-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 6 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.07A 5x1fA-3ebbA:
2.4
5x1fJ-3ebbA:
undetectable		 5x1fA-3ebbA:
19.27
5x1fJ-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 644
ARG A 680
MET A 676
LEU A 675
 None
 0.95A 5xdqN-3ebbA:
undetectable
5xdqW-3ebbA:
undetectable		 5xdqN-3ebbA:
19.27
5xdqW-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 596
THR A 662
ASN A 665
 None
 0.64A 6baaE-3ebbA:
undetectable		 6baaE-3ebbA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 596
THR A 662
ASN A 665
 None
 0.64A 6baaF-3ebbA:
undetectable		 6baaF-3ebbA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 596
THR A 662
ASN A 665
 None
 0.65A 6baaG-3ebbA:
undetectable		 6baaG-3ebbA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 596
THR A 662
ASN A 665
 None
 0.64A 6baaH-3ebbA:
undetectable		 6baaH-3ebbA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.13A 6nknJ-3ebbA:
undetectable		 6nknJ-3ebbA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ebb PHOSPHOLIPASE
A2-ACTIVATING
PROTEIN
(Homo
sapiens) 		4 / 5 TYR A 709
ARG A 680
MET A 676
LEU A 675
 None
 1.17A 6nknW-3ebbA:
undetectable		 6nknW-3ebbA:
12.31