SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ebj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		5 / 12 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
 1.00A 1uduB-3ebjA:
undetectable		 1uduB-3ebjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		5 / 12 ALA A  17
ILE A  13
ILE A  38
LEU A 109
PHE A  46
 None
 1.08A 1xozA-3ebjA:
undetectable		 1xozA-3ebjA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		3 / 3 TYR A 130
GLU A 195
THR A  40
 None
 0.84A 2y7hB-3ebjA:
undetectable		 2y7hB-3ebjA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		5 / 12 TYR A 110
ILE A 138
PHE A 105
THR A 143
ILE A 145
 None
 1.26A 3ndiA-3ebjA:
undetectable		 3ndiA-3ebjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		4 / 5 PHE A 148
ILE A 171
GLY A 121
HIS A 146
 None
 1.33A 3r0lD-3ebjA:
undetectable		 3r0lD-3ebjA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		4 / 8 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
 1.06A 3t3sE-3ebjA:
undetectable		 3t3sE-3ebjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		4 / 8 PHE A   4
PHE A   9
ASN A  33
ALA A  37
 None
 0.79A 3t3sF-3ebjA:
undetectable		 3t3sF-3ebjA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		3 / 3 PHE A 191
ASP A 189
ARG A 192
 None
 0.86A 4eahF-3ebjA:
undetectable		 4eahF-3ebjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		3 / 3 PHE A 191
ASP A 189
ARG A 192
 None
 0.85A 4eahG-3ebjA:
undetectable		 4eahG-3ebjA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		4 / 6 HIS A 146
LEU A 163
CYH A  45
LEU A 109
 None
 1.27A 5hrqD-3ebjA:
undetectable
5hrqG-3ebjA:
undetectable
5hrqH-3ebjA:
undetectable		 5hrqD-3ebjA:
8.64
5hrqG-3ebjA:
6.64
5hrqH-3ebjA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3ebj POLYMERASE ACIDIC
PROTEIN
(Influenza
A
virus) 		4 / 5 ASP A 111
PRO A 103
GLU A 141
THR A 143
 None
 1.00A 5uxcA-3ebjA:
undetectable		 5uxcA-3ebjA:
21.45