SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ec2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 11 ILE A 103
THR A  99
VAL A  71
ASN A 215
SER A 176
 None
 1.14A 3kpcA-3ec2A:
undetectable		 3kpcA-3ec2A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 12 ILE A 103
THR A  99
VAL A  71
ASN A 215
SER A 176
 None
 1.16A 3kpdB-3ec2A:
undetectable		 3kpdB-3ec2A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		4 / 8 GLY A  91
THR A 180
LEU A 218
PHE A  84
 ADP  A 222 (-3.2A)
None
None
None
 1.18A 4m5mA-3ec2A:
undetectable		 4m5mA-3ec2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 11 ASP A 198
TYR A 212
GLY A 151
SER A 201
GLY A 204
 None
 1.25A 4mm9A-3ec2A:
undetectable		 4mm9A-3ec2A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 10 ASP A 198
TYR A 212
GLY A 151
SER A 201
GLY A 204
 None
 1.22A 4mmcA-3ec2A:
undetectable		 4mmcA-3ec2A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 10 ASP A 198
VAL A 208
TYR A 212
GLY A 151
SER A 201
 None
 1.49A 4mmcA-3ec2A:
undetectable		 4mmcA-3ec2A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 11 ASP A 198
TYR A 212
GLY A 151
SER A 201
GLY A 204
 None
 1.20A 4xnxA-3ec2A:
undetectable		 4xnxA-3ec2A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 10 ASP A 198
TYR A 212
GLY A 151
SER A 201
GLY A 204
 None
 1.20A 4xpbA-3ec2A:
undetectable		 4xpbA-3ec2A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 12 ASP A 198
TYR A 212
GLY A 151
SER A 201
GLY A 204
 None
 1.21A 5i75A-3ec2A:
undetectable		 5i75A-3ec2A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 12 ASP A 198
THR A 177
ARG A 202
GLY A 151
LEU A 150
 None
 1.45A 5m50B-3ec2A:
undetectable		 5m50B-3ec2A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AY6_A_VORA501_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 9 TYR A  53
ALA A  98
ALA A  96
THR A 180
LEU A 218
 ADP  A 222 (-3.4A)
None
None
None
None
 1.36A 6ay6A-3ec2A:
undetectable		 6ay6A-3ec2A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 3ec2 DNA REPLICATION
PROTEIN DNAC
(Aquifex
aeolicus) 		5 / 12 ILE A 211
LEU A  82
ASN A 215
ASP A 148
ILE A 163
 None
None
None
MG  A 300 (-3.7A)
None
 1.49A 6dwnB-3ec2A:
undetectable		 6dwnB-3ec2A:
20.37