SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ec3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		5 / 10 VAL A 500
VAL A 472
TYR A 417
VAL A 415
LEU A 496
 None
 1.03A 1fe2A-3ec3A:
undetectable		 1fe2A-3ec3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 6 VAL A 413
VAL A 472
ILE A 450
ARG A 497
 None
 1.08A 1iepA-3ec3A:
undetectable		 1iepA-3ec3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 6 VAL A 413
VAL A 472
ILE A 450
ARG A 497
 None
 1.00A 2hyyA-3ec3A:
undetectable		 2hyyA-3ec3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		3 / 3 MET A 501
VAL A 415
GLU A 489
 None
 0.85A 2x9gA-3ec3A:
undetectable		 2x9gA-3ec3A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 6 PHE A 334
TYR A 321
HIS A 335
VAL A 304
 None
 1.23A 3lb3B-3ec3A:
undetectable		 3lb3B-3ec3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 6 VAL A 413
VAL A 472
ILE A 450
ARG A 497
 None
 1.03A 3ms9A-3ec3A:
undetectable		 3ms9A-3ec3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 6 VAL A 413
VAL A 472
ILE A 450
ARG A 497
 None
 1.05A 3mssA-3ec3A:
undetectable		 3mssA-3ec3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 7 VAL A 413
VAL A 472
ILE A 450
ARG A 497
 None
 1.08A 3mssB-3ec3A:
undetectable		 3mssB-3ec3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 6 VAL A 413
VAL A 472
ILE A 450
ARG A 497
 None
 1.06A 3mssC-3ec3A:
undetectable		 3mssC-3ec3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		5 / 12 ALA A 391
LEU A 353
ILE A 383
PHE A 334
GLY A 308
 None
 1.04A 4dm8B-3ec3A:
undetectable		 4dm8B-3ec3A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		5 / 10 ASP A 403
TYR A 407
ALA A 451
LEU A 412
LEU A 477
 None
 1.11A 4xj7A-3ec3A:
undetectable
4xj7B-3ec3A:
undetectable		 4xj7A-3ec3A:
22.60
4xj7B-3ec3A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 6 ALA A 474
VAL A 472
TYR A 417
VAL A 395
 None
 1.03A 5eclA-3ec3A:
undetectable		 5eclA-3ec3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		5 / 10 GLU A 467
GLY A 470
VAL A 460
LEU A 463
ALA A 485
 None
 1.02A 5o96C-3ec3A:
2.7
5o96D-3ec3A:
3.1		 5o96C-3ec3A:
22.34
5o96D-3ec3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		5 / 10 GLU A 467
GLY A 470
VAL A 460
LEU A 463
ALA A 485
 None
 0.98A 5o96E-3ec3A:
3.1
5o96F-3ec3A:
undetectable		 5o96E-3ec3A:
22.34
5o96F-3ec3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		4 / 5 LEU A 394
LYS A 441
LEU A 437
GLU A 438
 None
 1.25A 5weaA-3ec3A:
undetectable		 5weaA-3ec3A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		3 / 3 LYS A 352
VAL A 371
ASP A 373
 None
 0.61A 6fgdA-3ec3A:
2.5		 6fgdA-3ec3A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 3ec3 PROTEIN
DISULFIDE-ISOMERASE
A4
(Rattus
norvegicus) 		5 / 12 PHE A 443
ASN A 434
TYR A 417
LEU A 394
PHE A 448
 None
 0.89A 6r2eE-3ec3A:
undetectable		 6r2eE-3ec3A:
22.92