SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ec4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		5 / 10 ALA A 113
LEU A 114
MET A 145
LEU A 103
GLU A 105
 None
 1.49A 1a29A-3ec4A:
undetectable		 1a29A-3ec4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 6 MET A 218
GLU A  65
ALA A 220
LEU A 222
 None
 1.05A 1etb1-3ec4A:
undetectable		 1etb1-3ec4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 6 ARG A 216
ASN A 155
PRO A 152
ALA A 153
 None
 1.38A 2ejfB-3ec4A:
undetectable		 2ejfB-3ec4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2REZ_A_ACTA155_0
(MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 5 ARG A 149
GLY A  37
PRO A  38
PHE A  39
 None
 0.87A 2rezA-3ec4A:
undetectable		 2rezA-3ec4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 TYR A  36
ARG A 129
ARG A 151
GLN A 132
 None
None
None
ACT  A 229 ( 4.4A)
 1.09A 2vxaA-3ec4A:
0.7
2vxaC-3ec4A:
0.7
2vxaE-3ec4A:
0.7		 2vxaA-3ec4A:
16.30
2vxaC-3ec4A:
16.30
2vxaE-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 ARG A 151
TYR A  36
ARG A 129
GLN A 132
 None
None
None
ACT  A 229 ( 4.4A)
 1.12A 2vxaA-3ec4A:
0.7
2vxaB-3ec4A:
0.7
2vxaK-3ec4A:
0.7		 2vxaA-3ec4A:
16.30
2vxaB-3ec4A:
16.30
2vxaK-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 ARG A 151
TYR A  36
ARG A 129
GLN A 132
 None
None
None
ACT  A 229 ( 4.4A)
 1.09A 2vxaB-3ec4A:
0.7
2vxaC-3ec4A:
0.7
2vxaG-3ec4A:
0.7		 2vxaB-3ec4A:
16.30
2vxaC-3ec4A:
16.30
2vxaG-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 TYR A  36
ARG A 129
ARG A 151
GLN A 132
 None
None
None
ACT  A 229 ( 4.4A)
 1.09A 2vxaD-3ec4A:
0.7
2vxaF-3ec4A:
0.7
2vxaI-3ec4A:
0.7		 2vxaD-3ec4A:
16.30
2vxaF-3ec4A:
16.30
2vxaI-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 ARG A 151
TYR A  36
ARG A 129
GLN A 132
 None
None
None
ACT  A 229 ( 4.4A)
 1.12A 2vxaD-3ec4A:
0.7
2vxaE-3ec4A:
0.7
2vxaL-3ec4A:
0.7		 2vxaD-3ec4A:
16.30
2vxaE-3ec4A:
16.30
2vxaL-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 GLN A 132
ARG A 151
TYR A  36
ARG A 129
 ACT  A 229 ( 4.4A)
None
None
None
 1.09A 2vxaB-3ec4A:
0.7
2vxaG-3ec4A:
0.7
2vxaH-3ec4A:
0.7		 2vxaB-3ec4A:
16.30
2vxaG-3ec4A:
16.30
2vxaH-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 ARG A 151
TYR A  36
ARG A 129
GLN A 132
 None
None
None
ACT  A 229 ( 4.4A)
 1.11A 2vxaH-3ec4A:
0.7
2vxaI-3ec4A:
0.7
2vxaJ-3ec4A:
0.7		 2vxaH-3ec4A:
16.30
2vxaI-3ec4A:
16.30
2vxaJ-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 GLN A 132
TYR A  36
ARG A 129
ARG A 151
 ACT  A 229 ( 4.4A)
None
None
None
 1.11A 2vxaD-3ec4A:
0.7
2vxaJ-3ec4A:
0.7
2vxaL-3ec4A:
0.7		 2vxaD-3ec4A:
16.30
2vxaJ-3ec4A:
16.30
2vxaL-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 GLN A 132
ARG A 151
TYR A  36
ARG A 129
 ACT  A 229 ( 4.4A)
None
None
None
 1.10A 2vxaH-3ec4A:
0.7
2vxaJ-3ec4A:
0.7
2vxaK-3ec4A:
0.7		 2vxaH-3ec4A:
16.30
2vxaJ-3ec4A:
16.30
2vxaK-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		4 / 8 GLN A 132
ARG A 151
TYR A  36
ARG A 129
 ACT  A 229 ( 4.4A)
None
None
None
 1.08A 2vxaA-3ec4A:
0.7
2vxaK-3ec4A:
0.7
2vxaL-3ec4A:
0.7		 2vxaA-3ec4A:
16.30
2vxaK-3ec4A:
16.30
2vxaL-3ec4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		6 / 12 LEU A  29
ALA A  40
LEU A 223
LEU A  63
ARG A   9
LEU A  54
 None
 1.40A 3erdA-3ec4A:
undetectable		 3erdA-3ec4A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_B_DESB800_1
(ESTROGEN RECEPTOR
ALPHA)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		5 / 10 ALA A  40
LEU A 223
LEU A  63
ARG A   9
LEU A  54
 None
 1.44A 3erdB-3ec4A:
undetectable		 3erdB-3ec4A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		6 / 12 LEU A  29
ALA A  40
LEU A 223
LEU A  63
ARG A   9
LEU A  54
 None
 1.25A 3hm1A-3ec4A:
undetectable		 3hm1A-3ec4A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		5 / 12 LEU A 103
GLY A 161
GLY A 147
ILE A 178
VAL A 181
 None
 1.11A 4a6eA-3ec4A:
undetectable		 4a6eA-3ec4A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		6 / 11 LEU A  29
ALA A  40
LEU A 223
LEU A  63
ARG A   9
LEU A  54
 None
 1.37A 4zn7B-3ec4A:
undetectable		 4zn7B-3ec4A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY
(Novosphingobium
aromaticivorans) 		5 / 10 LEU A  29
ALA A  40
LEU A  63
ARG A   9
LEU A  54
 None
 1.33A 5dxeB-3ec4A:
undetectable		 5dxeB-3ec4A:
23.74