SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ecd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 4 ARG A 409
ALA A 405
ALA A 395
GLU A 391
 None
 1.23A 1e7bA-3ecdA:
undetectable		 1e7bA-3ecdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 5 ARG A 409
ALA A 405
ALA A 395
GLU A 391
 None
 1.22A 1e7cA-3ecdA:
2.9		 1e7cA-3ecdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 6 HIS A 226
LYS A 254
ALA A 258
VAL A 244
 None
 1.05A 1hk1A-3ecdA:
undetectable		 1hk1A-3ecdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 8 ARG A 366
LEU A 321
PRO A 221
GLY A 178
 None
 0.87A 1hrkA-3ecdA:
2.6		 1hrkA-3ecdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 8 ARG A 366
LEU A 321
PRO A 221
GLY A 178
 None
 0.97A 1hrkB-3ecdA:
undetectable		 1hrkB-3ecdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 ALA A 210
ILE A 209
VAL A 228
LEU A 202
ILE A 176
 None
 0.96A 1xozA-3ecdA:
undetectable		 1xozA-3ecdA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.81A 2avvD-3ecdA:
undetectable		 2avvD-3ecdA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.86A 2avvE-3ecdA:
undetectable		 2avvE-3ecdA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.98A 2f80A-3ecdA:
undetectable		 2f80A-3ecdA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.32A 2f8gB-3ecdA:
undetectable		 2f8gB-3ecdA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.89A 2hs1B-3ecdA:
undetectable		 2hs1B-3ecdA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.91A 2hs2B-3ecdA:
undetectable		 2hs2B-3ecdA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.20A 2ienA-3ecdA:
undetectable		 2ienA-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.79A 2nmzA-3ecdA:
undetectable		 2nmzA-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 GLY A 216
ALA A 215
ILE A 209
PRO A 370
ILE A 291
 None
 0.89A 2nmzB-3ecdA:
undetectable		 2nmzB-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 8 ARG A 366
LEU A 321
PRO A 221
GLY A 178
 None
 0.79A 2po5A-3ecdA:
undetectable		 2po5A-3ecdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 8 ARG A 366
LEU A 321
PRO A 221
GLY A 178
 None
 0.81A 2po5B-3ecdA:
2.3		 2po5B-3ecdA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.92A 2pymA-3ecdA:
undetectable		 2pymA-3ecdA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.91A 2pymB-3ecdA:
undetectable		 2pymB-3ecdA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.91A 2pynA-3ecdA:
undetectable		 2pynA-3ecdA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.26A 2q63A-3ecdA:
undetectable		 2q63A-3ecdA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.89A 2q63B-3ecdA:
undetectable		 2q63B-3ecdA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.88A 2q64A-3ecdA:
undetectable		 2q64A-3ecdA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.87A 2qakA-3ecdA:
undetectable		 2qakA-3ecdA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 GLY A 364
GLY A 351
ILE A 361
LEU A 326
VAL A 310
 None
 0.87A 2yqzB-3ecdA:
undetectable		 2yqzB-3ecdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 8 GLY A 378
GLU A 381
PHE A 421
GLY A 376
 None
None
None
GOL  A 425 ( 4.7A)
 0.76A 3aruA-3ecdA:
undetectable		 3aruA-3ecdA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.31A 3bvbA-3ecdA:
undetectable		 3bvbA-3ecdA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 1.06A 3cyxA-3ecdA:
undetectable		 3cyxA-3ecdA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_2
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.81A 3d1xB-3ecdA:
undetectable		 3d1xB-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.05A 3d1zA-3ecdA:
undetectable		 3d1zA-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 11 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.85A 3el1A-3ecdA:
undetectable		 3el1A-3ecdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 VAL A 310
LEU A  36
THR A 369
ARG A 366
GLY A 316
 None
 1.32A 3j6pB-3ecdA:
undetectable		 3j6pB-3ecdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.94A 3jvyA-3ecdA:
undetectable		 3jvyA-3ecdA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.29A 3jw2A-3ecdA:
undetectable		 3jw2A-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.34A 3k4vA-3ecdA:
undetectable		 3k4vA-3ecdA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.27A 3k4vB-3ecdA:
undetectable		 3k4vB-3ecdA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.36A 3lzuB-3ecdA:
undetectable		 3lzuB-3ecdA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 1.07A 3mwsA-3ecdA:
undetectable		 3mwsA-3ecdA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.19A 3ndtA-3ecdA:
undetectable		 3ndtA-3ecdA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.26A 3ndtB-3ecdA:
undetectable		 3ndtB-3ecdA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.90A 3nduA-3ecdA:
undetectable		 3nduA-3ecdA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_2
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.88A 3nduB-3ecdA:
undetectable		 3nduB-3ecdA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.99A 3nu3A-3ecdA:
undetectable		 3nu3A-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.23A 3nu5A-3ecdA:
undetectable		 3nu5A-3ecdA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.98A 3oxxA-3ecdA:
undetectable		 3oxxA-3ecdA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.96A 3pwmA-3ecdA:
undetectable		 3pwmA-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 8 ARG A 409
ALA A 343
LEU A 340
ASP A 403
 None
 1.02A 3qj7A-3ecdA:
undetectable
3qj7D-3ecdA:
undetectable		 3qj7A-3ecdA:
20.46
3qj7D-3ecdA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 ASP A 325
SER A 363
THR A 362
ILE A 361
PHE A 393
 None
 1.29A 3rzeA-3ecdA:
undetectable		 3rzeA-3ecdA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.89A 3tkgA-3ecdA:
undetectable		 3tkgA-3ecdA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.28A 3tkwB-3ecdA:
undetectable		 3tkwB-3ecdA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.24A 3tl9A-3ecdA:
undetectable		 3tl9A-3ecdA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		6 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
VAL A 294
ILE A 291
 None
 1.26A 3tl9B-3ecdA:
undetectable		 3tl9B-3ecdA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 8 PHE A 382
VAL A  34
ILE A 345
ILE A 365
 None
 0.90A 3uqbA-3ecdA:
undetectable		 3uqbA-3ecdA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 6 GLY A 122
ARG A 190
ILE A 175
LEU A 147
 None
 1.17A 4ac9C-3ecdA:
2.8		 4ac9C-3ecdA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 5 LEU A 121
ILE A 158
ALA A 177
PHE A 191
 None
 1.04A 4dc3B-3ecdA:
2.3		 4dc3B-3ecdA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 PHE A  90
ALA A 210
THR A 235
GLU A 281
ALA A 282
 None
 1.17A 4fiaA-3ecdA:
undetectable		 4fiaA-3ecdA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 PHE A  90
ALA A 210
THR A 235
GLU A 281
ALA A 282
 None
 1.17A 4fiaA-3ecdA:
undetectable		 4fiaA-3ecdA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 11 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 1.02A 4hlaB-3ecdA:
undetectable		 4hlaB-3ecdA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.92A 4jecB-3ecdA:
undetectable		 4jecB-3ecdA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 9 ALA A 273
ALA A  50
ALA A  46
SER A  44
ALA A 276
 None
 1.26A 4twdA-3ecdA:
undetectable
4twdB-3ecdA:
undetectable
4twdC-3ecdA:
undetectable
4twdD-3ecdA:
undetectable
4twdE-3ecdA:
undetectable		 4twdA-3ecdA:
22.50
4twdB-3ecdA:
22.50
4twdC-3ecdA:
22.50
4twdD-3ecdA:
22.50
4twdE-3ecdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		4 / 6 ASP A 292
THR A 289
TYR A 290
THR A 373
 None
None
GOL  A 425 (-4.4A)
None
 1.39A 5b6iB-3ecdA:
undetectable		 5b6iB-3ecdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.91A 5e5kB-3ecdA:
undetectable		 5e5kB-3ecdA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		3 / 3 GLY A 316
GLN A 299
LYS A 306
 None
 1.00A 5imsB-3ecdA:
2.4		 5imsB-3ecdA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 VAL A 310
LEU A  36
THR A 369
ARG A 366
GLY A 316
 None
 1.29A 5ogcB-3ecdA:
2.4		 5ogcB-3ecdA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.89A 5t8hB-3ecdA:
undetectable		 5t8hB-3ecdA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 12 LEU A 295
GLY A 216
ALA A 215
PRO A 370
ILE A 291
 None
 0.95A 6dh3B-3ecdA:
undetectable		 6dh3B-3ecdA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3ecd SERINE
HYDROXYMETHYLTRANSFE
RASE 2
(Burkholderia
pseudomallei) 		5 / 9 ILE A 361
ALA A 334
GLY A 333
LEU A 326
GLY A 402
 None
 1.08A 6nm4B-3ecdA:
undetectable		 6nm4B-3ecdA:
18.68