SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 12 VAL A  24
LEU A  74
LEU A 312
LEU A 314
GLU A 127
None
1.12A 1kw0A-3eckA:
undetectable
1kw0A-3eckA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
3 / 3 PHE A 128
LEU A 173
MET A 193
None
0.91A 1mx1D-3eckA:
undetectable
1mx1D-3eckA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 10 GLU A 149
LEU A 150
ILE A 228
GLU A  46
LEU A  41
None
1.24A 1wopA-3eckA:
undetectable
1wopA-3eckA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 12 GLY A 174
ASP A 172
ASP A  14
PRO A  13
PHE A 128
None
1.06A 2f8lA-3eckA:
undetectable
2f8lA-3eckA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 6 THR A 198
VAL A 199
GLU A 267
SER A 251
None
None
FE2  A 500 (-2.7A)
None
1.14A 3b6rB-3eckA:
undetectable
3b6rB-3eckA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 8 TYR A 255
SER A 251
HIS A 214
ARG A 243
None
None
FE2  A 500 (-3.4A)
CL  A 501 (-3.0A)
1.13A 3b9lA-3eckA:
undetectable
3b9lA-3eckA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
3 / 3 ASN A 263
HIS A 264
VAL A  25
None
0.88A 3elzB-3eckA:
undetectable
3elzB-3eckA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
3 / 3 ARG A 293
GLU A 242
ASP A 260
CL  A 501 (-4.3A)
None
None
0.91A 3g2oA-3eckA:
undetectable
3g2oA-3eckA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 7 ASN A 280
GLU A 179
GLN A 182
TYR A 273
None
1.28A 3ugrA-3eckA:
undetectable
3ugrA-3eckA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 6 GLU A 127
PHE A  79
TYR A  20
PHE A 129
None
1.09A 4a97E-3eckA:
undetectable
4a97E-3eckA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 HIS A 214
ARG A 293
TYR A 257
GLU A 267
ALA A 203
FE2  A 500 (-3.4A)
CL  A 501 (-4.3A)
None
FE2  A 500 (-2.7A)
None
1.25A 4ir0A-3eckA:
7.1
4ir0B-3eckA:
7.1
4ir0A-3eckA:
19.02
4ir0B-3eckA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
FE2  A 500 (-3.4A)
None
0.59A 4ir0A-3eckA:
7.1
4ir0B-3eckA:
7.1
4ir0A-3eckA:
19.02
4ir0B-3eckA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FE2  A 500 (-3.4A)
None
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
0.53A 4ir0A-3eckA:
7.1
4ir0B-3eckA:
7.1
4ir0A-3eckA:
19.02
4ir0B-3eckA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 12 HIS A 214
ARG A 293
TYR A 257
GLU A 267
ALA A 203
FE2  A 500 (-3.4A)
CL  A 501 (-4.3A)
None
FE2  A 500 (-2.7A)
None
1.30A 4jd1A-3eckA:
6.9
4jd1B-3eckA:
7.1
4jd1A-3eckA:
19.02
4jd1B-3eckA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 12 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
FE2  A 500 (-3.4A)
None
0.53A 4jd1A-3eckA:
6.9
4jd1B-3eckA:
7.1
4jd1A-3eckA:
19.02
4jd1B-3eckA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 12 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FE2  A 500 (-3.4A)
None
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
0.63A 4jd1A-3eckA:
6.9
4jd1B-3eckA:
7.1
4jd1A-3eckA:
19.02
4jd1B-3eckA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 12 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
FE2  A 500 (-3.4A)
None
0.50A 4jh3A-3eckA:
6.7
4jh3B-3eckA:
7.1
4jh3A-3eckA:
14.88
4jh3B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FE2  A 500 (-3.4A)
None
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
0.48A 4jh3A-3eckA:
6.7
4jh3B-3eckA:
7.1
4jh3A-3eckA:
14.88
4jh3B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
FE2  A 500 (-3.4A)
None
0.41A 4jh4A-3eckA:
7.1
4jh4B-3eckA:
6.9
4jh4A-3eckA:
14.88
4jh4B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 ALA A 203
HIS A 214
ARG A 293
TYR A 257
GLU A 267
None
FE2  A 500 (-3.4A)
CL  A 501 (-4.3A)
None
FE2  A 500 (-2.7A)
1.28A 4jh4A-3eckA:
7.1
4jh4B-3eckA:
6.9
4jh4A-3eckA:
14.88
4jh4B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FE2  A 500 (-3.4A)
None
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
0.44A 4jh4A-3eckA:
7.1
4jh4B-3eckA:
6.9
4jh4A-3eckA:
14.88
4jh4B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
FE2  A 500 (-3.4A)
None
0.46A 4jh5A-3eckA:
7.1
4jh5B-3eckA:
6.8
4jh5A-3eckA:
14.88
4jh5B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 11 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FE2  A 500 (-3.4A)
None
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
0.48A 4jh5A-3eckA:
7.1
4jh5B-3eckA:
6.8
4jh5A-3eckA:
14.88
4jh5B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 10 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
FE2  A 500 (-3.4A)
None
0.49A 4jh6A-3eckA:
7.1
4jh6B-3eckA:
6.9
4jh6A-3eckA:
14.88
4jh6B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 10 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FE2  A 500 (-3.4A)
None
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
0.50A 4jh6A-3eckA:
7.1
4jh6B-3eckA:
6.9
4jh6A-3eckA:
14.88
4jh6B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 10 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
FE2  A 500 (-3.4A)
None
0.47A 4jh8A-3eckA:
7.1
4jh8B-3eckA:
6.7
4jh8A-3eckA:
14.88
4jh8B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 10 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FE2  A 500 (-3.4A)
None
FE2  A 500 (-3.4A)
None
FE2  A 500 (-2.7A)
0.48A 4jh8A-3eckA:
7.1
4jh8B-3eckA:
6.7
4jh8A-3eckA:
14.88
4jh8B-3eckA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
3 / 3 ARG A 265
GLU A 329
TYR A 257
None
0.93A 4r29D-3eckA:
undetectable
4r29D-3eckA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 8 GLY A 297
GLN A 291
SER A 356
ASN A 290
None
0.98A 4wryA-3eckA:
undetectable
4wryA-3eckA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 8 GLY A 297
GLN A 291
SER A 356
ASN A 290
None
0.99A 4wrzA-3eckA:
undetectable
4wrzA-3eckA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 7 GLU A  22
ARG A 117
GLU A 127
ALA A  78
None
0.98A 4zz8A-3eckA:
undetectable
4zz8A-3eckA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 4 VAL A 159
GLY A 207
ARG A 324
VAL A 163
None
1.29A 5d4nA-3eckA:
undetectable
5d4nB-3eckA:
undetectable
5d4nA-3eckA:
13.77
5d4nB-3eckA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 6 GLY A 249
ASP A 154
ILE A 268
TYR A 257
None
1.09A 5iwuA-3eckA:
undetectable
5iwuA-3eckA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
5 / 10 ARG A 117
PRO A 125
GLY A 111
THR A 132
ALA A 115
None
1.20A 5vyhA-3eckA:
undetectable
5vyhA-3eckA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)
3eck PROTEIN
(HOMOPROTOCATECHUATE
2,3-DIOXYGENASE)

(Brevibacterium
fuscum)
4 / 6 GLY A 166
GLN A 158
TYR A 126
TYR A 169
None
1.22A 6ag0A-3eckA:
undetectable
6ag0A-3eckA:
13.43