SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ecn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMY_A_AZMA400_1
(MURINE CARBONIC
ANHYDRASE V)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 11 HIS A 596
HIS A 560
LEU A 514
LEU A 565
THR A 568
ZN  A   1 (-3.5A)
ZN  A   1 (-3.4A)
None
None
None
1.19A 1dmyA-3ecnA:
undetectable
1dmyA-3ecnA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 8 THR A 668
ASP A 597
HIS A 556
HIS A 560
MG  A   2 ( 4.7A)
MG  A   2 ( 2.8A)
None
ZN  A   1 (-3.4A)
1.02A 1ei6D-3ecnA:
undetectable
1ei6D-3ecnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 ASP A 482
GLU A 535
TYR A 516
VAL A 484
PRO A 485
None
1.17A 1ituB-3ecnA:
undetectable
1ituB-3ecnA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 8 VAL A 665
HIS A 560
SER A 561
VAL A 564
None
ZN  A   1 (-3.4A)
None
None
0.93A 1jtvA-3ecnA:
undetectable
1jtvA-3ecnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 8 VAL A 665
TYR A 549
SER A 561
VAL A 564
None
1.06A 1jtvA-3ecnA:
undetectable
1jtvA-3ecnA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 TYR A 555
HIS A 556
ALA A 742
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
1.25A 1udtA-3ecnA:
35.2
1udtA-3ecnA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.30A 1v54A-3ecnA:
undetectable
1v54C-3ecnA:
undetectable
1v54A-3ecnA:
18.32
1v54C-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.33A 1v54N-3ecnA:
undetectable
1v54P-3ecnA:
undetectable
1v54N-3ecnA:
18.32
1v54P-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.31A 1v55A-3ecnA:
undetectable
1v55C-3ecnA:
undetectable
1v55A-3ecnA:
18.32
1v55C-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
3 / 3 ASP A 801
GLU A 575
ARG A 524
None
0.66A 1wopA-3ecnA:
undetectable
1wopA-3ecnA:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
9 / 12 TYR A 555
HIS A 556
HIS A 600
MET A 670
ASN A 729
ILE A 744
SER A 777
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.42A 1xlxA-3ecnA:
44.7
1xlxA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 HIS A 556
HIS A 600
ILE A 744
SER A 777
PHE A 781
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.69A 1xlxB-3ecnA:
44.9
1xlxB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
7 / 12 TYR A 555
HIS A 556
HIS A 600
MET A 670
ILE A 744
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.33A 1xlxB-3ecnA:
44.9
1xlxB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
8 / 12 TYR A 555
HIS A 556
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
None
None
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.37A 1xmuA-3ecnA:
44.6
1xmuA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
0.38A 1xmuB-3ecnA:
44.7
1xmuB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
ILE A 744
SER A 777
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.37A 1xomA-3ecnA:
44.8
1xomA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
7 / 12 TYR A 555
HIS A 556
MET A 670
ILE A 744
SER A 777
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.41A 1xomB-3ecnA:
45.0
1xomB-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 MET A 670
ASP A 726
PRO A 730
SER A 780
PHE A 781
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-3.5A)
1.12A 1xoqA-3ecnA:
44.9
1xoqA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
ILE A 744
SER A 777
PHE A 781
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.41A 1xoqA-3ecnA:
44.9
1xoqA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
3 / 3 ASN A 729
TRP A 740
GLN A 778
None
None
IBM  A   3 (-3.4A)
0.16A 1xoqA-3ecnA:
44.9
1xoqA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
8 / 12 TYR A 555
HIS A 556
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
None
None
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.37A 1xoqB-3ecnA:
45.0
1xoqB-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
3 / 3 MET A 670
ASN A 729
GLN A 778
IBM  A   3 (-4.5A)
None
IBM  A   3 (-3.4A)
0.34A 1xoqB-3ecnA:
45.0
1xoqB-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
6 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.44A 1xosA-3ecnA:
44.8
1xosA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
6 / 12 TYR A 555
HIS A 556
ILE A 744
GLN A 778
PHE A 781
ILE A 786
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
None
1.31A 1xotA-3ecnA:
44.8
1xotA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
7 / 12 TYR A 555
HIS A 556
MET A 670
ILE A 744
SER A 777
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.5A)
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.57A 1xotA-3ecnA:
44.8
1xotA-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
6 / 12 TYR A 555
HIS A 556
ASN A 729
ILE A 744
SER A 777
PHE A 781
None
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.60A 1xotB-3ecnA:
44.7
1xotB-3ecnA:
34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
7 / 12 TYR A 555
HIS A 556
MET A 670
ASN A 729
ILE A 744
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.40A 1xotB-3ecnA:
44.7
1xotB-3ecnA:
34.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.30A 2dyrA-3ecnA:
undetectable
2dyrC-3ecnA:
undetectable
2dyrA-3ecnA:
18.32
2dyrC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.32A 2dyrN-3ecnA:
undetectable
2dyrP-3ecnA:
undetectable
2dyrN-3ecnA:
18.32
2dyrP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.29A 2dysA-3ecnA:
undetectable
2dysC-3ecnA:
undetectable
2dysA-3ecnA:
18.32
2dysC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.29A 2dysN-3ecnA:
undetectable
2dysP-3ecnA:
undetectable
2dysN-3ecnA:
18.32
2dysP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.31A 2eijA-3ecnA:
undetectable
2eijC-3ecnA:
undetectable
2eijA-3ecnA:
18.32
2eijC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.32A 2eijN-3ecnA:
undetectable
2eijP-3ecnA:
undetectable
2eijN-3ecnA:
18.32
2eijP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.32A 2eikA-3ecnA:
undetectable
2eikC-3ecnA:
undetectable
2eikA-3ecnA:
18.32
2eikC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.34A 2eikN-3ecnA:
undetectable
2eikP-3ecnA:
undetectable
2eikN-3ecnA:
18.32
2eikP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.31A 2eilA-3ecnA:
undetectable
2eilC-3ecnA:
undetectable
2eilA-3ecnA:
18.32
2eilC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.32A 2eilN-3ecnA:
undetectable
2eilP-3ecnA:
undetectable
2eilN-3ecnA:
18.32
2eilP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.30A 2eimA-3ecnA:
undetectable
2eimC-3ecnA:
undetectable
2eimA-3ecnA:
18.32
2eimC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.30A 2eimN-3ecnA:
undetectable
2eimP-3ecnA:
undetectable
2eimN-3ecnA:
18.32
2eimP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.30A 2einA-3ecnA:
undetectable
2einC-3ecnA:
undetectable
2einA-3ecnA:
18.32
2einC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.36A 2einN-3ecnA:
undetectable
2einP-3ecnA:
undetectable
2einN-3ecnA:
18.32
2einP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 11 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.37A 2h42A-3ecnA:
35.0
2h42A-3ecnA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.46A 2h42B-3ecnA:
34.8
2h42B-3ecnA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
6 / 12 TYR A 555
HIS A 556
ILE A 744
GLU A 747
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.92A 2weyA-3ecnA:
36.5
2weyA-3ecnA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.31A 2y69A-3ecnA:
undetectable
2y69C-3ecnA:
undetectable
2y69A-3ecnA:
18.32
2y69C-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.33A 2zxwA-3ecnA:
undetectable
2zxwC-3ecnA:
undetectable
2zxwA-3ecnA:
18.32
2zxwC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.32A 2zxwN-3ecnA:
undetectable
2zxwP-3ecnA:
undetectable
2zxwN-3ecnA:
18.32
2zxwP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.33A 3abkA-3ecnA:
undetectable
3abkC-3ecnA:
undetectable
3abkA-3ecnA:
18.32
3abkC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.31A 3abkN-3ecnA:
undetectable
3abkP-3ecnA:
undetectable
3abkN-3ecnA:
18.32
3abkP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.30A 3abmN-3ecnA:
undetectable
3abmP-3ecnA:
undetectable
3abmN-3ecnA:
18.32
3abmP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.36A 3ag1A-3ecnA:
0.9
3ag1C-3ecnA:
undetectable
3ag1A-3ecnA:
18.32
3ag1C-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.34A 3ag1N-3ecnA:
undetectable
3ag1P-3ecnA:
undetectable
3ag1N-3ecnA:
18.32
3ag1P-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_A_CHDA525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.33A 3ag2A-3ecnA:
undetectable
3ag2C-3ecnA:
undetectable
3ag2A-3ecnA:
18.32
3ag2C-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.34A 3ag2N-3ecnA:
undetectable
3ag2P-3ecnA:
undetectable
3ag2N-3ecnA:
18.32
3ag2P-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.31A 3ag3A-3ecnA:
undetectable
3ag3C-3ecnA:
undetectable
3ag3A-3ecnA:
18.32
3ag3C-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.32A 3ag3N-3ecnA:
undetectable
3ag3P-3ecnA:
undetectable
3ag3N-3ecnA:
18.32
3ag3P-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.33A 3ag4A-3ecnA:
undetectable
3ag4C-3ecnA:
undetectable
3ag4A-3ecnA:
18.32
3ag4C-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.33A 3ag4N-3ecnA:
undetectable
3ag4P-3ecnA:
undetectable
3ag4N-3ecnA:
18.32
3ag4P-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.32A 3asnA-3ecnA:
undetectable
3asnC-3ecnA:
undetectable
3asnA-3ecnA:
18.32
3asnC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.58A 3b2rA-3ecnA:
30.5
3b2rA-3ecnA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 11 TYR A 555
HIS A 556
ILE A 774
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.55A 3b2rB-3ecnA:
30.7
3b2rB-3ecnA:
25.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 MET A 670
ASN A 729
PRO A 730
SER A 780
PHE A 781
IBM  A   3 (-4.5A)
None
None
None
IBM  A   3 (-3.5A)
1.01A 3g4lA-3ecnA:
44.8
3g4lA-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
9 / 12 TYR A 555
HIS A 556
MET A 670
ASN A 729
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
None
None
IBM  A   3 (-4.5A)
None
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.43A 3g4lA-3ecnA:
44.8
3g4lA-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
PHE A 781
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.5A)
0.33A 3g4lB-3ecnA:
44.8
3g4lB-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
8 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
ASN A 729
PRO A 730
TRP A 740
ILE A 744
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
None
IBM  A   3 (-4.3A)
0.31A 3g4lC-3ecnA:
44.8
3g4lC-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
3 / 3 SER A 777
GLN A 778
PHE A 781
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.22A 3g4lC-3ecnA:
44.8
3g4lC-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
9 / 12 TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
GLN A 778
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
0.41A 3g4lD-3ecnA:
44.7
3g4lD-3ecnA:
32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 9 TYR A 555
ILE A 744
GLN A 778
PHE A 781
ILE A 786
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
None
1.45A 3iakA-3ecnA:
43.0
3iakA-3ecnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
6 / 9 TYR A 555
MET A 670
ASN A 729
ILE A 744
GLN A 778
PHE A 781
None
IBM  A   3 (-4.5A)
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.53A 3iakA-3ecnA:
43.0
3iakA-3ecnA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 TYR A 555
HIS A 556
GLN A 778
PHE A 781
None
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.43A 3jwqC-3ecnA:
37.9
3jwqC-3ecnA:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
6 / 9 TYR A 555
ASN A 729
PRO A 730
ILE A 744
GLN A 778
PHE A 781
None
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.36A 3tvxA-3ecnA:
44.3
3tvxA-3ecnA:
34.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 7 TYR A 555
ASN A 729
ILE A 744
GLN A 778
PHE A 781
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.38A 3tvxB-3ecnA:
44.5
3tvxB-3ecnA:
34.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 LEU A 716
TRP A 793
LEU A 688
THR A 580
None
0.85A 4udaA-3ecnA:
1.6
4udaA-3ecnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.34A 5b1aN-3ecnA:
undetectable
5b1aP-3ecnA:
undetectable
5b1aN-3ecnA:
18.32
5b1aP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 8 ASP A 621
TYR A 619
HIS A 676
LEU A 608
None
1.19A 5b1bA-3ecnA:
undetectable
5b1bC-3ecnA:
undetectable
5b1bP-3ecnA:
undetectable
5b1bA-3ecnA:
18.32
5b1bC-3ecnA:
21.49
5b1bP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.34A 5b1bN-3ecnA:
undetectable
5b1bP-3ecnA:
undetectable
5b1bN-3ecnA:
18.32
5b1bP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.37A 5b3sN-3ecnA:
undetectable
5b3sP-3ecnA:
undetectable
5b3sN-3ecnA:
18.32
5b3sP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.36A 5iy5A-3ecnA:
undetectable
5iy5C-3ecnA:
undetectable
5iy5A-3ecnA:
18.32
5iy5C-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 SER A 561
ALA A 592
PRO A 513
TRP A 541
ALA A 593
None
1.38A 5tzoA-3ecnA:
undetectable
5tzoA-3ecnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
5 / 12 SER A 561
ALA A 592
PRO A 513
TRP A 541
ALA A 593
None
1.37A 5tzoC-3ecnA:
undetectable
5tzoC-3ecnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.36A 5x19N-3ecnA:
undetectable
5x19P-3ecnA:
undetectable
5x19N-3ecnA:
18.32
5x19P-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.36A 5x1bN-3ecnA:
undetectable
5x1bP-3ecnA:
undetectable
5x1bN-3ecnA:
18.32
5x1bP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.41A 5x1fN-3ecnA:
undetectable
5x1fP-3ecnA:
1.6
5x1fN-3ecnA:
18.32
5x1fP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.36A 5zcqN-3ecnA:
undetectable
5zcqP-3ecnA:
undetectable
5zcqN-3ecnA:
18.32
5zcqP-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.33A 6nknA-3ecnA:
undetectable
6nknC-3ecnA:
undetectable
6nknA-3ecnA:
18.32
6nknC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 6 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.38A 6nmpA-3ecnA:
0.7
6nmpC-3ecnA:
undetectable
6nmpA-3ecnA:
18.32
6nmpC-3ecnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo
sapiens)
4 / 7 ASP A 621
THR A 622
TYR A 619
HIS A 676
None
1.39A 6nmpN-3ecnA:
undetectable
6nmpP-3ecnA:
undetectable
6nmpN-3ecnA:
18.32
6nmpP-3ecnA:
21.49