SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ed3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 188
VAL A 190
SER A 182
LYS A 183
 ACT  A1106 (-4.6A)
None
None
None
 1.29A 2j9cA-3ed3A:
undetectable
2j9cB-3ed3A:
undetectable
2j9cC-3ed3A:
undetectable		 2j9cA-3ed3A:
19.53
2j9cB-3ed3A:
19.53
2j9cC-3ed3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 273
ARG A 275
ASN A 268
ASN A  47
 None
None
None
ACT  A1108 (-4.0A)
 0.93A 2nyrA-3ed3A:
undetectable		 2nyrA-3ed3A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  65
SER A  67
PHE A  69
ILE A 145
 None
 0.87A 3ko0B-3ed3A:
undetectable		 3ko0B-3ed3A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  65
SER A  67
PHE A  69
ILE A 145
 None
 0.81A 3ko0S-3ed3A:
undetectable		 3ko0S-3ed3A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 282
SER A 291
GLY A 285
ASN A 268
 None
 0.92A 3lslA-3ed3A:
undetectable
3lslD-3ed3A:
undetectable		 3lslA-3ed3A:
24.77
3lslD-3ed3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 231
LEU A 212
PHE A 181
TYR A 222
 None
 1.12A 3po7A-3ed3A:
undetectable		 3po7A-3ed3A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 251
TRP A 258
ASP A 255
THR A 225
 None
 1.21A 3vqrA-3ed3A:
undetectable		 3vqrA-3ed3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 181
VAL A 248
GLU A 259
 None
 0.75A 4fvqA-3ed3A:
undetectable		 4fvqA-3ed3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 274
GLY A 200
PHE A 278
ASN A  47
TYR A 156
 None
None
None
ACT  A1108 (-4.0A)
None
 1.42A 4pclB-3ed3A:
undetectable		 4pclB-3ed3A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 274
LEU A 247
ASN A 266
ILE A 265
 None
 0.79A 4rmjA-3ed3A:
undetectable		 4rmjA-3ed3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 235
ILE A 163
ILE A 207
VAL A 179
PHE A 250
 None
 1.16A 4y0pA-3ed3A:
undetectable		 4y0pA-3ed3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 179
ILE A 163
ASN A 209
VAL A 235
 None
 1.26A 5ajqA-3ed3A:
undetectable		 5ajqA-3ed3A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 257
VAL A 248
PHE A 273
THR A 277
 None
 0.96A 5t7bA-3ed3A:
undetectable		 5t7bA-3ed3A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 7 SER A 149
LEU A  76
ALA A  72
ILE A  31
 None
 0.89A 5te8C-3ed3A:
undetectable		 5te8C-3ed3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 212
ILE A 236
TYR A 222
 None
 0.52A 5uunB-3ed3A:
undetectable		 5uunB-3ed3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 290
THR A  49
PRO A 112
ILE A 153
 EDO  A2763 (-3.7A)
None
None
None
 0.90A 6a4iA-3ed3A:
undetectable		 6a4iA-3ed3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 284
THR A  49
PRO A 112
ILE A 153
 EDO  A2763 (-3.5A)
None
None
None
 1.03A 6a4iA-3ed3A:
undetectable		 6a4iA-3ed3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 3ed3 PROTEIN
DISULFIDE-ISOMERASE
MPD1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 107
LEU A  51
ALA A  73
ALA A  72
 None
 0.75A 6a7jA-3ed3A:
undetectable		 6a7jA-3ed3A:
12.29