SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ed4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 11 SER A 247
VAL A 241
TYR A 285
LEU A 252
VAL A  66
 None
 1.27A 1i9jH-3ed4A:
undetectable
1i9jL-3ed4A:
undetectable		 1i9jH-3ed4A:
18.47
1i9jL-3ed4A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 8 SER A 111
ILE A 423
GLY A 422
GLY A 108
 None
 0.68A 1me7A-3ed4A:
undetectable		 1me7A-3ed4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		3 / 3 ARG A 345
ASP A  51
ASN A 170
 None
NA  A 519 (-3.3A)
None
 0.87A 1nbhA-3ed4A:
undetectable		 1nbhA-3ed4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		3 / 3 ARG A 345
ASP A  51
ASN A 170
 None
NA  A 519 (-3.3A)
None
 0.86A 1nbhD-3ed4A:
undetectable		 1nbhD-3ed4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 6 VAL A 219
LEU A 223
PHE A 232
MET A 306
 None
 1.15A 1x8vA-3ed4A:
undetectable		 1x8vA-3ed4A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 4 LEU A 393
PRO A  43
ILE A 128
LEU A 131
 None
 0.79A 1ya4B-3ed4A:
undetectable		 1ya4B-3ed4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 4 LEU A 393
PRO A  43
ILE A 128
LEU A 131
 None
 0.97A 1ya4C-3ed4A:
undetectable		 1ya4C-3ed4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_A_8MOA501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 11 VAL A 241
ASN A 288
THR A  68
LEU A  53
PHE A 316
 None
 1.04A 1z11A-3ed4A:
undetectable		 1z11A-3ed4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 11 VAL A 241
ASN A 288
THR A  68
LEU A  53
PHE A 316
 None
 1.06A 1z11B-3ed4A:
undetectable		 1z11B-3ed4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 10 VAL A 241
ASN A 288
THR A  68
LEU A  53
PHE A 316
 None
 1.01A 1z11C-3ed4A:
undetectable		 1z11C-3ed4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 10 VAL A 241
ASN A 288
THR A  68
LEU A  53
PHE A 316
 None
 1.07A 1z11D-3ed4A:
undetectable		 1z11D-3ed4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		3 / 3 ASP A 293
VAL A 241
PRO A 322
 None
 0.69A 2avvA-3ed4A:
undetectable		 2avvA-3ed4A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 5 TYR A 285
VAL A 241
ASP A  52
SER A 318
 None
None
NA  A 519 (-3.0A)
None
 1.32A 2x45A-3ed4A:
undetectable		 2x45A-3ed4A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 5 TYR A 285
VAL A 241
ASP A  52
SER A 318
 None
None
NA  A 519 (-3.0A)
None
 1.26A 2x45C-3ed4A:
undetectable		 2x45C-3ed4A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 10 GLY A  97
ARG A  95
LEU A 145
ILE A 109
MET A 162
 None
 1.35A 3adsA-3ed4A:
undetectable		 3adsA-3ed4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 5 ILE A 128
TYR A 137
MET A 388
ILE A 313
 None
 1.23A 3eteB-3ed4A:
undetectable
3eteC-3ed4A:
undetectable		 3eteB-3ed4A:
23.27
3eteC-3ed4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 7 ASN A  70
LEU A 300
ASP A 301
LYS A 304
 None
 1.12A 3lslA-3ed4A:
undetectable
3lslD-3ed4A:
undetectable		 3lslA-3ed4A:
18.31
3lslD-3ed4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 6 ASN A  70
LEU A 300
ASP A 301
LYS A 304
 None
 1.12A 3lslG-3ed4A:
undetectable		 3lslG-3ed4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 11 VAL A 241
ASN A 288
THR A  68
LEU A  53
PHE A 316
 None
 1.03A 3t3rA-3ed4A:
undetectable		 3t3rA-3ed4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		3 / 3 GLY A 212
SER A 211
TRP A 197
 None
 0.76A 4e7cD-3ed4A:
0.3		 4e7cD-3ed4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 9 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.24A 4mm5A-3ed4A:
undetectable		 4mm5A-3ed4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 11 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.27A 4mm9A-3ed4A:
undetectable		 4mm9A-3ed4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 9 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.26A 4mmbA-3ed4A:
undetectable		 4mmbA-3ed4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 9 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.23A 4mmeA-3ed4A:
undetectable		 4mmeA-3ed4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 9 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.18A 4mmfA-3ed4A:
undetectable		 4mmfA-3ed4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 9 VAL A 192
ALA A 246
GLY A 272
PHE A 270
SER A 243
 None
 1.23A 4mmfB-3ed4A:
undetectable		 4mmfB-3ed4A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 5 ASN A 170
ALA A 172
GLY A 173
ASP A 273
 None
None
SO4  A 520 (-3.7A)
None
 0.98A 4n48A-3ed4A:
undetectable		 4n48A-3ed4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 6 LEU A 292
VAL A 241
ALA A  50
THR A  68
LEU A  58
 None
 1.16A 4o0wA-3ed4A:
undetectable		 4o0wA-3ed4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 12 ALA A 237
LEU A  99
SER A  91
SER A  92
GLY A 163
 None
None
NA  A 519 ( 2.3A)
None
None
 0.96A 4rzvA-3ed4A:
undetectable		 4rzvA-3ed4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 12 VAL A  79
ILE A 128
SER A 403
ILE A 360
LEU A  98
 None
 1.20A 5hbsA-3ed4A:
undetectable		 5hbsA-3ed4A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 9 ILE A 360
ALA A 358
ILE A 359
ILE A  48
LEU A  74
 None
 1.14A 5mvmA-3ed4A:
undetectable
5mvmE-3ed4A:
undetectable		 5mvmA-3ed4A:
9.92
5mvmE-3ed4A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 4 LEU A 245
MET A 191
ILE A 289
LEU A 252
 None
 1.34A 5nfpA-3ed4A:
undetectable		 5nfpA-3ed4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 11 GLY A 212
GLU A 240
ASP A 293
ALA A 294
SER A 216
 None
 1.22A 5x6yA-3ed4A:
undetectable		 5x6yA-3ed4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 10 GLY A 212
GLU A 240
ASP A 293
ALA A 294
SER A 216
 None
 1.21A 5x6yB-3ed4A:
3.1		 5x6yB-3ed4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 11 GLY A 212
GLU A 240
ASP A 293
ALA A 294
SER A 216
 None
 1.03A 5x6yC-3ed4A:
2.7		 5x6yC-3ed4A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 12 PRO A 367
PHE A  81
SER A 372
MET A 388
LEU A 385
 None
 0.97A 6b52A-3ed4A:
undetectable		 6b52A-3ed4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 12 VAL A 405
PHE A  81
SER A 372
MET A 388
LEU A 385
 None
 0.97A 6b52A-3ed4A:
undetectable		 6b52A-3ed4A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		5 / 12 ALA A  86
GLY A 352
GLY A 321
ARG A 345
TRP A 350
 None
 1.02A 6clxA-3ed4A:
undetectable		 6clxA-3ed4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 3ed4 ARYLSULFATASE
(Escherichia
coli) 		4 / 6 TYR A 486
TYR A 377
GLU A 402
LYS A 417
 None
 1.46A 6d8pA-3ed4A:
0.0		 6d8pA-3ed4A:
22.70