SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ed5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3ed5 YFNB
(Bacillus
subtilis) 		5 / 12 ILE A 178
PHE A   9
GLY A 180
LEU A 112
LEU A 220
 None
 1.17A 1fm6X-3ed5A:
undetectable		 1fm6X-3ed5A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ed5 YFNB
(Bacillus
subtilis) 		4 / 5 ARG A 132
ASP A 181
SER A 182
ASN A 201
 None
 1.15A 1kiaB-3ed5A:
3.3		 1kiaB-3ed5A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ed5 YFNB
(Bacillus
subtilis) 		4 / 6 ARG A 132
ASP A 181
SER A 182
ASN A 201
 None
 1.15A 1kiaC-3ed5A:
3.4		 1kiaC-3ed5A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3ed5 YFNB
(Bacillus
subtilis) 		5 / 9 GLY A  84
SER A  72
LEU A  87
TYR A  45
LEU A  29
 None
None
None
FMT  A 239 (-4.7A)
None
 1.21A 1y7iA-3ed5A:
3.5		 1y7iA-3ed5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3ed5 YFNB
(Bacillus
subtilis) 		5 / 8 LEU A 227
TYR A   4
ILE A 179
ILE A 226
ILE A 217
 None
 1.01A 2bu8A-3ed5A:
undetectable		 2bu8A-3ed5A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 3ed5 YFNB
(Bacillus
subtilis) 		5 / 12 LEU A   7
LEU A 223
ALA A 105
ILE A 109
ILE A  15
 None
 1.02A 2bxcA-3ed5A:
3.5		 2bxcA-3ed5A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 3ed5 YFNB
(Bacillus
subtilis) 		4 / 6 LEU A 227
TYR A   4
ILE A 179
ILE A 226
 None
 0.87A 2q8hA-3ed5A:
undetectable		 2q8hA-3ed5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3ed5 YFNB
(Bacillus
subtilis) 		3 / 3 ARG A 132
ASP A 181
GLN A  50
 None
 0.94A 3lcvB-3ed5A:
2.5		 3lcvB-3ed5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ed5 YFNB
(Bacillus
subtilis) 		3 / 3 TYR A 160
ASP A 186
ASP A  13
 None
FMT  A 237 ( 4.8A)
None
 0.83A 3ou6B-3ed5A:
undetectable		 3ou6B-3ed5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3ed5 YFNB
(Bacillus
subtilis) 		4 / 7 ILE A 212
PRO A 213
GLU A 216
GLN A  50
 None
 0.89A 4g0uB-3ed5A:
2.0		 4g0uB-3ed5A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3ed5 YFNB
(Bacillus
subtilis) 		4 / 8 GLN A 100
ASP A  12
GLY A  98
LEU A  24
 None
FMT  A 244 (-3.9A)
None
FMT  A 242 (-4.1A)
 0.97A 5hwaA-3ed5A:
undetectable		 5hwaA-3ed5A:
24.00