SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ed8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3ed8 YELLOW FLUORESCENCE
PROTEIN
(Aequorea
victoria) 		5 / 12 PHE A  84
ILE A 212
GLY A  91
SER A  86
GLU A 115
 None
 0.92A 1vq1B-3ed8A:
undetectable		 1vq1B-3ed8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3ed8 YELLOW FLUORESCENCE
PROTEIN
(Aequorea
victoria) 		3 / 3 ASN A 194
LEU A 141
HIS A 193
 None
 0.80A 2q6fB-3ed8A:
0.8		 2q6fB-3ed8A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3ed8 YELLOW FLUORESCENCE
PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.9A)
None
None
 1.16A 3t3rB-3ed8A:
undetectable		 3t3rB-3ed8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3ed8 YELLOW FLUORESCENCE
PROTEIN
(Aequorea
victoria) 		5 / 9 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.9A)
None
None
 1.18A 3t3rC-3ed8A:
undetectable		 3t3rC-3ed8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3ed8 YELLOW FLUORESCENCE
PROTEIN
(Aequorea
victoria) 		5 / 10 PHE A  71
VAL A 112
ASN A 121
ILE A  14
PHE A   8
 None
None
CRO  A  66 ( 3.9A)
None
None
 1.13A 3t3rD-3ed8A:
undetectable		 3t3rD-3ed8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 3ed8 YELLOW FLUORESCENCE
PROTEIN
(Aequorea
victoria) 		4 / 6 THR A 128
ASN A  23
GLY A  24
ASP A  21
 None
 1.22A 3w9tE-3ed8A:
undetectable		 3w9tE-3ed8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3ed8 YELLOW FLUORESCENCE
PROTEIN
(Aequorea
victoria) 		3 / 3 VAL A  16
LYS A 113
MET A  88
 None
 1.08A 5nknA-3ed8A:
undetectable		 5nknA-3ed8A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BBS_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 3ed8 YELLOW FLUORESCENCE
PROTEIN
(Aequorea
victoria) 		5 / 12 HIS A 148
ILE A 185
PHE A  84
THR A  63
THR A  62
 CRO  A  66 ( 3.9A)
None
None
None
CRO  A  66 ( 4.5A)
 1.16A 6bbsA-3ed8A:
undetectable		 6bbsA-3ed8A:
14.02