SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3edl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		4 / 5 VAL D 213
THR D 214
GLN D 289
ILE D 150
 None
 1.45A 1ss4A-3edlD:
0.6		 1ss4A-3edlD:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		3 / 3 ARG D  80
ARG D  78
PRO D  81
 None
ANP  D 500 ( 3.7A)
ANP  D 500 ( 4.7A)
 1.05A 2wljA-3edlD:
undetectable		 2wljA-3edlD:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		3 / 3 ASP D 306
LEU D 226
VAL D 259
 MG  D 501 ( 4.0A)
None
None
 0.67A 4jecB-3edlD:
undetectable		 4jecB-3edlD:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		3 / 3 MET D 265
ASP D 225
PHE D 224
 None
 1.05A 4xeyA-3edlD:
undetectable		 4xeyA-3edlD:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		3 / 3 MET D 265
ASP D 225
PHE D 224
 None
 0.97A 4xeyB-3edlD:
undetectable		 4xeyB-3edlD:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		5 / 12 TYR D 161
SER D 303
ALA D 191
ALA D 143
TYR D 139
 None
 1.36A 4ymgA-3edlD:
undetectable		 4ymgA-3edlD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		5 / 12 TYR D 161
SER D 303
ALA D 191
ALA D 143
TYR D 139
 None
 1.35A 4ymgB-3edlD:
undetectable		 4ymgB-3edlD:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		4 / 7 PHE D 215
ALA D 183
GLY D 186
TYR D 139
 None
 0.99A 5uxdA-3edlD:
undetectable		 5uxdA-3edlD:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		3 / 3 LYS D 301
LEU D 298
ARG D 293
 None
 0.92A 5yw0A-3edlD:
undetectable		 5yw0A-3edlD:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		5 / 12 ALA D 377
GLY D 165
ASP D 397
ALA D 396
PHE D 125
 None
ANP  D 500 ( 3.3A)
None
None
None
 1.31A 5zvgA-3edlD:
undetectable		 5zvgA-3edlD:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		5 / 12 ALA D 377
GLY D 165
ASP D 397
ALA D 396
PHE D 125
 None
ANP  D 500 ( 3.3A)
None
None
None
 1.33A 5zvgB-3edlD:
undetectable		 5zvgB-3edlD:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		4 / 8 GLY D 154
ILE D 150
LYS D 155
ASP D 364
 None
 0.99A 6ag0C-3edlD:
undetectable		 6ag0C-3edlD:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 3edl KINESIN13 MOTOR
DOMAIN
(Drosophila
melanogaster) 		4 / 6 THR D 171
MET D 190
THR D 142
LEU D 307
 None
 1.13A 6mvxA-3edlD:
undetectable
6mvxB-3edlD:
undetectable
6mvxC-3edlD:
undetectable		 6mvxA-3edlD:
19.94
6mvxB-3edlD:
19.94
6mvxC-3edlD:
19.94