SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3edn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		4 / 6 CYH A 175
VAL A 174
HIS A 212
CYH A 201
 None
 1.46A 1ekjG-3ednA:
undetectable
1ekjH-3ednA:
undetectable		 1ekjG-3ednA:
20.94
1ekjH-3ednA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		4 / 6 ASN A  20
PHE A  12
ALA A  22
GLY A  76
 SO4  A 300 ( 4.7A)
None
None
None
 0.98A 1gfzA-3ednA:
undetectable		 1gfzA-3ednA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		4 / 7 ALA A 125
GLY A 234
ILE A 285
THR A 273
 None
 0.77A 1t7iB-3ednA:
undetectable		 1t7iB-3ednA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		4 / 7 ALA A 125
GLY A 234
ILE A 285
THR A 273
 None
 0.79A 1t7jB-3ednA:
undetectable		 1t7jB-3ednA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		4 / 6 LEU A  96
GLU A  99
ILE A 104
PRO A 106
 None
 1.07A 2fcnA-3ednA:
undetectable
2fcnB-3ednA:
undetectable		 2fcnA-3ednA:
14.96
2fcnB-3ednA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		5 / 12 PHE A  12
ASN A  20
GLY A 230
MET A 121
GLY A  79
 None
SO4  A 300 ( 4.7A)
SO4  A 300 (-3.5A)
None
None
 1.16A 2fqyA-3ednA:
undetectable		 2fqyA-3ednA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 CYH A 175
CYH A 201
HIS A 212
 None
 0.82A 2iwkA-3ednA:
undetectable		 2iwkA-3ednA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 CYH A 175
CYH A 201
HIS A 212
 None
 0.77A 2iwkB-3ednA:
undetectable		 2iwkB-3ednA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		5 / 12 PHE A 185
PRO A 199
VAL A 167
LEU A 149
SER A 141
 None
 1.50A 2xrlA-3ednA:
undetectable		 2xrlA-3ednA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		4 / 8 SER A 141
VAL A 188
LEU A 189
ALA A 219
 None
 0.80A 3ax7A-3ednA:
undetectable		 3ax7A-3ednA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		5 / 10 ILE A 200
ILE A 155
PRO A 154
ILE A 197
THR A 229
 None
None
None
None
SO4  A 300 (-4.5A)
 1.18A 3clbD-3ednA:
undetectable		 3clbD-3ednA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		5 / 12 HIS A 263
GLY A 213
TYR A 205
GLU A 257
GLY A 259
 None
 1.33A 3f8wB-3ednA:
undetectable		 3f8wB-3ednA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		5 / 10 ILE A 200
ILE A 155
PRO A 154
ILE A 197
THR A 229
 None
None
None
None
SO4  A 300 (-4.5A)
 1.15A 3hbbD-3ednA:
undetectable		 3hbbD-3ednA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 LYS A 264
ILE A  24
PHE A  50
 None
 0.98A 3j7zS-3ednA:
undetectable
3j7za-3ednA:
undetectable		 3j7zS-3ednA:
18.18
3j7za-3ednA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		5 / 12 THR A 229
VAL A 228
THR A 160
ILE A 166
HIS A 198
 SO4  A 300 (-4.5A)
None
None
None
None
 1.27A 4s0vA-3ednA:
undetectable		 4s0vA-3ednA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 LYS A  93
ILE A 109
ILE A 119
 None
 0.71A 4y0qA-3ednA:
undetectable		 4y0qA-3ednA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		5 / 12 GLY A  19
ASP A 226
VAL A 228
THR A 229
ALA A 289
 None
SO4  A 300 ( 4.8A)
None
SO4  A 300 (-4.5A)
None
 1.14A 5kpcB-3ednA:
undetectable		 5kpcB-3ednA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 MET A 121
GLN A 123
ARG A 122
 None
 1.09A 5m35B-3ednA:
undetectable		 5m35B-3ednA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 MET A 121
GLN A 123
ARG A 122
 None
 1.11A 5m36A-3ednA:
undetectable		 5m36A-3ednA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		5 / 10 ILE A 142
ALA A 139
LEU A 138
ILE A 155
ILE A 200
 None
 0.95A 5mvmD-3ednA:
undetectable
5mvmE-3ednA:
undetectable		 5mvmD-3ednA:
14.72
5mvmE-3ednA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		4 / 6 PRO A 199
GLY A 213
LEU A 172
VAL A 169
 None
 0.85A 5x80A-3ednA:
undetectable
5x80B-3ednA:
undetectable		 5x80A-3ednA:
20.98
5x80B-3ednA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 MET A 121
GLN A 123
ARG A 122
 None
 1.11A 6fn9A-3ednA:
undetectable		 6fn9A-3ednA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 MET A 121
GLN A 123
ARG A 122
 None
 1.09A 6fnaB-3ednA:
undetectable		 6fnaB-3ednA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3edn PHENAZINE
BIOSYNTHESIS
PROTEIN, PHZF FAMILY
(Bacillus
anthracis) 		3 / 3 MET A 121
GLN A 123
ARG A 122
 None
 1.10A 6fnbA-3ednA:
undetectable		 6fnbA-3ednA:
23.10