SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3edv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		4 / 6 ALA A1786
ARG A1754
LEU A1783
TRP A1787
 None
 1.13A 1gahA-3edvA:
undetectable		 1gahA-3edvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		4 / 4 ILE A1853
LEU A1856
VAL A1860
ALA A1867
 None
 0.76A 1mz9A-3edvA:
undetectable		 1mz9A-3edvA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		4 / 5 ILE A1853
LEU A1856
VAL A1860
ALA A1867
 None
 0.82A 1mz9C-3edvA:
undetectable		 1mz9C-3edvA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		3 / 3 ARG A1741
GLU A1738
GLN A1737
 MG  A1006 ( 3.9A)
None
MG  A1006 ( 4.5A)
 1.09A 2p16A-3edvA:
undetectable		 2p16A-3edvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		4 / 5 LEU A1897
GLN A1854
HIS A1825
LEU A1828
 None
 1.09A 3ce6D-3edvA:
undetectable		 3ce6D-3edvA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		3 / 3 CYH A1900
PRO A1829
ASP A1852
 None
 0.88A 3hlwB-3edvA:
undetectable		 3hlwB-3edvA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		4 / 7 ARG A1980
LEU A1832
ARG A1915
PHE A1914
 None
 0.95A 3ln1B-3edvA:
undetectable		 3ln1B-3edvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		4 / 7 ARG A1980
LEU A1832
ARG A1915
PHE A1914
 None
 0.95A 3ln1C-3edvA:
undetectable		 3ln1C-3edvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		4 / 5 ARG A1980
LEU A1832
ARG A1915
PHE A1914
 None
 0.95A 3ln1D-3edvA:
undetectable		 3ln1D-3edvA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		3 / 3 TYR A1983
THR A1910
GLU A1987
 None
 0.62A 4df3A-3edvA:
undetectable		 4df3A-3edvA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		3 / 3 TYR A1983
THR A1910
GLU A1987
 None
 0.61A 4df3B-3edvA:
undetectable		 4df3B-3edvA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3edv SPECTRIN BETA CHAIN,
BRAIN 1
(Homo
sapiens) 		3 / 3 CYH A1900
PRO A1829
ASP A1852
 None
 1.01A 4pm5A-3edvA:
undetectable		 4pm5A-3edvA:
21.19