SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3edy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 7 TYR A 441
ASP A 528
GLU A 529
ARG A 371
 None
None
None
EDO  A 703 ( 4.6A)
 1.43A 1b2iA-3edyA:
undetectable		 1b2iA-3edyA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		3 / 3 ARG A 375
ARG A 371
ARG A  28
 None
EDO  A 703 ( 4.6A)
None
 1.02A 1l7fA-3edyA:
undetectable		 1l7fA-3edyA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		3 / 3 ARG A 375
ARG A 371
ARG A  28
 None
EDO  A 703 ( 4.6A)
None
 1.01A 1l7hA-3edyA:
undetectable		 1l7hA-3edyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 4 GLY A 539
VAL A 518
TRP A 542
GLY A 547
 CA  A   1 (-4.3A)
CA  A   1 (-4.8A)
None
None
 1.33A 1ng8A-3edyA:
undetectable		 1ng8A-3edyA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA8_0
(GRAMICIDIN A)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 4 GLY A 541
VAL A 518
TRP A 542
GLY A 547
 CA  A   1 (-4.2A)
CA  A   1 (-4.8A)
None
None
 1.44A 1ng8A-3edyA:
undetectable		 1ng8A-3edyA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 4 GLY A 539
VAL A 518
TRP A 542
GLY A 547
 CA  A   1 (-4.3A)
CA  A   1 (-4.8A)
None
None
 1.33A 1ng8B-3edyA:
undetectable		 1ng8B-3edyA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB8_0
(GRAMICIDIN A)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 4 GLY A 541
VAL A 518
TRP A 542
GLY A 547
 CA  A   1 (-4.2A)
CA  A   1 (-4.8A)
None
None
 1.44A 1ng8B-3edyA:
undetectable		 1ng8B-3edyA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		3 / 3 ASP A 543
VAL A 426
PRO A 419
 CA  A   1 (-3.3A)
None
EDO  A 701 (-4.8A)
 0.78A 2avvA-3edyA:
undetectable		 2avvA-3edyA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 8 SER A 125
PHE A 138
ALA A 136
LEU A 173
 None
 1.03A 2bxkA-3edyA:
undetectable		 2bxkA-3edyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 7 ASN A 489
GLU A 490
LEU A 494
TYR A  79
 None
None
None
EDO  A 704 (-4.6A)
 1.22A 2w8yA-3edyA:
undetectable		 2w8yA-3edyA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 9 ALA A 285
VAL A 216
GLY A 217
GLY A 219
ALA A 252
 None
None
None
NAG  A 565 ( 4.1A)
NAG  A 565 ( 3.8A)
 0.90A 2z0yA-3edyA:
undetectable		 2z0yA-3edyA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB8_A_IMNA800_1
(PROSTAGLANDIN
REDUCTASE 2)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 9 PHE A 378
TYR A 336
LEU A 354
VAL A 385
LEU A 344
 None
 1.43A 2zb8A-3edyA:
0.0		 2zb8A-3edyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 12 ALA A 425
SER A 538
PRO A 544
GLY A 549
THR A 550
 None
 1.09A 2zifA-3edyA:
undetectable		 2zifA-3edyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 4 SER A 456
GLY A 473
GLY A 389
GLY A 409
 None
 0.90A 3bogB-3edyA:
undetectable
3bogD-3edyA:
undetectable		 3bogB-3edyA:
undetectable
3bogD-3edyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 12 GLY A 389
VAL A 323
PRO A 379
VAL A 340
LEU A 344
 None
 0.89A 3m6wA-3edyA:
undetectable		 3m6wA-3edyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		6 / 12 GLY A 409
GLY A 410
VAL A 323
PRO A 379
VAL A 340
LEU A 344
 None
 1.38A 3m6wA-3edyA:
undetectable		 3m6wA-3edyA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 9 ARG A 208
VAL A 388
GLY A 483
PRO A 551
THR A 550
 NAG  A 564 (-3.8A)
None
None
None
None
 1.22A 3spkA-3edyA:
undetectable		 3spkA-3edyA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 5 LEU A 556
LEU A 557
LEU A 487
SER A 486
 None
 1.03A 3vhuA-3edyA:
undetectable		 3vhuA-3edyA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 5 HIS A 298
GLN A 264
GLY A 262
SER A 294
 None
 0.92A 4fu8A-3edyA:
undetectable		 4fu8A-3edyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 7 ILE A 337
GLY A 171
ALA A 335
GLU A  24
GLN A 306
 EDO  A 702 ( 4.2A)
None
None
None
None
 1.42A 4g0uB-3edyA:
2.1		 4g0uB-3edyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 12 ALA A 363
SER A 381
GLY A 411
ASP A 360
THR A 474
 None
 1.34A 4mm4A-3edyA:
undetectable		 4mm4A-3edyA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		3 / 3 ALA A  41
GLN A 128
GLY A 107
 None
 0.56A 4odoC-3edyA:
undetectable		 4odoC-3edyA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 8 ALA A 454
ILE A 488
GLY A 483
THR A 322
 None
 0.85A 4r20A-3edyA:
undetectable		 4r20A-3edyA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 12 LEU A 355
VAL A 480
GLY A 482
SER A 486
LEU A 487
 None
 1.08A 4rrxA-3edyA:
undetectable		 4rrxA-3edyA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		3 / 3 GLU A 302
TYR A 157
GLU A  24
 None
 0.78A 4ryaA-3edyA:
0.7		 4ryaA-3edyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 5 GLU A 302
TYR A 325
PHE A 230
TYR A 336
 None
 1.25A 4twdA-3edyA:
0.0
4twdE-3edyA:
0.0		 4twdA-3edyA:
19.29
4twdE-3edyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		4 / 7 GLU A 302
TYR A 325
PHE A 230
TYR A 336
 None
 1.20A 4twdF-3edyA:
undetectable
4twdJ-3edyA:
undetectable		 4twdF-3edyA:
19.29
4twdJ-3edyA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		5 / 12 LEU A 485
SER A 486
GLN A 225
VAL A 388
VAL A 452
 None
 1.11A 5dpdA-3edyA:
undetectable		 5dpdA-3edyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 3edy TRIPEPTIDYL-PEPTIDAS
E 1
(Homo
sapiens) 		3 / 3 ARG A 492
PRO A 563
TYR A  79
 None
None
EDO  A 704 (-4.6A)
 1.04A 5tzoB-3edyA:
undetectable		 5tzoB-3edyA:
14.88