SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ee1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		5 / 9 PHE A 278
THR A 198
LEU A 209
ASP A 189
ILE A 186
 None
 1.39A 1gebA-3ee1A:
undetectable		 1gebA-3ee1A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		3 / 3 GLY A  76
ASP A  75
ASN A 130
 None
 0.66A 1vq1A-3ee1A:
undetectable		 1vq1A-3ee1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		4 / 8 GLY A 372
THR A 373
ALA A 269
VAL A 326
 None
 0.86A 2a1hA-3ee1A:
undetectable
2a1hB-3ee1A:
undetectable		 2a1hA-3ee1A:
19.95
2a1hB-3ee1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		4 / 8 VAL A 326
GLY A 372
THR A 373
ALA A 269
 None
 0.87A 2a1hA-3ee1A:
undetectable
2a1hB-3ee1A:
undetectable		 2a1hA-3ee1A:
19.95
2a1hB-3ee1A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		5 / 12 LEU A 374
ILE A 186
ILE A 216
VAL A 344
VAL A 369
 None
 0.95A 2ygnA-3ee1A:
undetectable		 2ygnA-3ee1A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		4 / 7 ILE A 395
HIS A 135
LYS A 133
ILE A 292
 None
 0.85A 3eteD-3ee1A:
undetectable
3eteF-3ee1A:
undetectable		 3eteD-3ee1A:
21.17
3eteF-3ee1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		4 / 7 ILE A 395
HIS A 135
LYS A 133
TYR A 293
 None
 0.90A 3eteD-3ee1A:
undetectable
3eteF-3ee1A:
undetectable		 3eteD-3ee1A:
21.17
3eteF-3ee1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		3 / 3 ASP A 214
ASN A 244
PHE A 254
 None
 0.65A 5dsgB-3ee1A:
undetectable		 5dsgB-3ee1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		3 / 3 PRO A 125
ILE A 321
SER A  64
 None
 0.79A 5fsaA-3ee1A:
undetectable		 5fsaA-3ee1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		5 / 10 VAL A 344
LEU A 219
ALA A 277
SER A 346
PHE A 278
 None
 1.39A 5mm4B-3ee1A:
undetectable		 5mm4B-3ee1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		5 / 10 VAL A 344
LEU A 231
ALA A 277
SER A 346
PHE A 278
 None
 1.24A 5mm4B-3ee1A:
undetectable		 5mm4B-3ee1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		4 / 7 ILE A 323
PHE A 202
ASP A 267
SER A 263
 None
 1.00A 5nr3A-3ee1A:
undetectable		 5nr3A-3ee1A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3ee1 EFFECTOR PROTEIN
VIRA
(Shigella
flexneri) 		5 / 12 ASP A 178
ARG A 389
LEU A 349
ALA A 394
ILE A 292
 None
 1.04A 5vc0A-3ee1A:
undetectable		 5vc0A-3ee1A:
20.39