SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 PHE A 125
LEU A  75
TYR A  37
LEU A  96
LEU A  87
 PG6  A 163 ( 4.2A)
PG6  A 163 ( 4.8A)
None
None
None
 1.35A 1e7wA-3eeaA:
undetectable		 1e7wA-3eeaA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		4 / 6 LEU A  67
VAL A  29
VAL A 109
ILE A  34
 PG6  A 163 ( 4.9A)
None
None
None
 1.00A 2hyyA-3eeaA:
undetectable		 2hyyA-3eeaA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 VAL A  61
LEU A  79
ILE A  72
LEU A 103
ASP A  45
 None
None
PG6  A 163 (-4.4A)
PG6  A 163 (-4.7A)
None
 1.06A 3hecA-3eeaA:
undetectable		 3hecA-3eeaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 LEU A  21
ILE A 143
ILE A  18
ALA A  49
VAL A 109
 None
 1.07A 3vw1D-3eeaA:
undetectable		 3vw1D-3eeaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 LEU A  21
THR A 140
ILE A 143
ILE A  18
ALA A  49
 None
 1.07A 3vw1D-3eeaA:
undetectable		 3vw1D-3eeaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		4 / 8 LEU A  25
LEU A  28
VAL A  29
MET A 126
 None
 0.94A 4oj4A-3eeaA:
undetectable		 4oj4A-3eeaA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 ILE A  72
ALA A 111
LEU A  96
LEU A  87
PHE A 125
 PG6  A 163 (-4.4A)
None
None
None
PG6  A 163 ( 4.2A)
 1.18A 4pbhA-3eeaA:
undetectable		 4pbhA-3eeaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3eea GAF DOMAIN/HD DOMAIN
PROTEIN
(Geobacter
sulfurreducens) 		5 / 12 LEU A  96
PHE A 135
ILE A  72
ALA A  35
ILE A  34
 None
None
PG6  A 163 (-4.4A)
PG6  A 163 ( 4.3A)
None
 0.72A 5veuB-3eeaA:
undetectable		 5veuB-3eeaA:
17.57