SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 ALA A 107
TYR A  86
ILE A 110
ILE A 104
 None
 1.00A 2dcfA-3eefA:
undetectable		 2dcfA-3eefA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ASP A   9
ASP A  50
HIS A  52
TYR A  93
CYH A 123
 None
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 1.28A 2wt9A-3eefA:
22.2		 2wt9A-3eefA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_A_NIOA1216_1
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		7 / 10 ASP A   9
PHE A  14
ASP A  50
TRP A  62
HIS A  65
TYR A  93
CYH A 123
 None
None
ZN  A 183 (-2.6A)
None
ZN  A 183 (-3.4A)
None
None
 0.70A 2wt9A-3eefA:
22.2		 2wt9A-3eefA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_B_NIOB1216_1
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		6 / 9 ASP A   9
PHE A  14
ASP A  50
TRP A  62
HIS A  65
CYH A 123
 None
None
ZN  A 183 (-2.6A)
None
ZN  A 183 (-3.4A)
None
 0.70A 2wt9B-3eefA:
22.2		 2wt9B-3eefA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WT9_B_NIOB1216_1
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 ASP A   9
PHE A  14
LEU A  19
ASP A  50
CYH A 123
 None
None
None
ZN  A 183 (-2.6A)
None
 1.02A 2wt9B-3eefA:
22.2		 2wt9B-3eefA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 THR A  99
GLY A  95
ALA A  92
VAL A  46
ASP A 130
 None
 1.00A 2yvlB-3eefA:
3.5		 2yvlB-3eefA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 ALA A 107
TYR A  86
ILE A 110
ILE A 104
 None
 1.00A 2zm7A-3eefA:
undetectable		 2zm7A-3eefA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ALA A 107
TYR A  86
ILE A 110
ILE A 104
 None
 1.00A 2zm8A-3eefA:
undetectable		 2zm8A-3eefA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ALA A 107
TYR A  86
ILE A 110
ILE A 104
 None
 1.03A 2zmaA-3eefA:
undetectable		 2zmaA-3eefA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 PRO A  81
VAL A  75
THR A 127
GLY A  95
 None
 1.14A 3elzB-3eefA:
undetectable		 3elzB-3eefA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		6 / 11 ASP A   9
ASP A  50
GLU A  58
HIS A  52
TYR A  93
ILE A 122
 None
ZN  A 183 (-2.6A)
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 1.47A 3o94A-3eefA:
25.2		 3o94A-3eefA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		7 / 11 ASP A   9
PHE A  14
ASP A  50
GLU A  58
HIS A  65
TYR A  93
ILE A 122
 None
None
ZN  A 183 (-2.6A)
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 0.63A 3o94A-3eefA:
25.2		 3o94A-3eefA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		6 / 11 ASP A   9
ASP A  50
GLU A  58
HIS A  52
TYR A  93
ILE A 122
 None
ZN  A 183 (-2.6A)
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 1.46A 3o94B-3eefA:
25.0		 3o94B-3eefA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		7 / 11 ASP A   9
PHE A  14
ASP A  50
GLU A  58
HIS A  65
TYR A  93
ILE A 122
 None
None
ZN  A 183 (-2.6A)
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 0.65A 3o94B-3eefA:
25.0		 3o94B-3eefA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		6 / 11 ASP A   9
ASP A  50
GLU A  58
HIS A  52
TYR A  93
ILE A 122
 None
ZN  A 183 (-2.6A)
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 1.47A 3o94C-3eefA:
25.1		 3o94C-3eefA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		7 / 11 ASP A   9
PHE A  14
ASP A  50
GLU A  58
HIS A  65
TYR A  93
ILE A 122
 None
None
ZN  A 183 (-2.6A)
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 0.62A 3o94C-3eefA:
25.1		 3o94C-3eefA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		6 / 11 ASP A   9
ASP A  50
GLU A  58
HIS A  52
TYR A  93
ILE A 122
 None
ZN  A 183 (-2.6A)
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 1.47A 3o94D-3eefA:
25.1		 3o94D-3eefA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		7 / 11 ASP A   9
PHE A  14
ASP A  50
GLU A  58
HIS A  65
TYR A  93
ILE A 122
 None
None
ZN  A 183 (-2.6A)
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
None
 0.61A 3o94D-3eefA:
25.1		 3o94D-3eefA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_A_NIOA311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 ASP A   9
ASP A  50
TRP A  62
HIS A  65
LYS A  90
 None
ZN  A 183 (-2.6A)
None
ZN  A 183 (-3.4A)
None
 0.56A 3r2jA-3eefA:
23.3		 3r2jA-3eefA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_B_NIOB311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		7 / 11 ASP A   9
PHE A  14
ASP A  50
TRP A  62
HIS A  65
LYS A  90
TYR A  93
 None
None
ZN  A 183 (-2.6A)
None
ZN  A 183 (-3.4A)
None
None
 0.73A 3r2jB-3eefA:
22.7		 3r2jB-3eefA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_C_NIOC311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		8 / 12 ASP A   9
PHE A  14
ASP A  50
HIS A  52
TRP A  62
HIS A  65
LYS A  90
TYR A  93
 None
None
ZN  A 183 (-2.6A)
ZN  A 183 (-3.4A)
None
ZN  A 183 (-3.4A)
None
None
 0.65A 3r2jC-3eefA:
23.2		 3r2jC-3eefA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2J_D_NIOD311_1
(ALPHA/BETA-HYDROLASE
-LIKE PROTEIN)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		7 / 11 ASP A   9
PHE A  14
ASP A  50
TRP A  62
HIS A  65
LYS A  90
TYR A  93
 None
None
ZN  A 183 (-2.6A)
None
ZN  A 183 (-3.4A)
None
None
 0.65A 3r2jD-3eefA:
23.0		 3r2jD-3eefA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		6 / 12 ALA A 144
VAL A   7
ILE A  35
ILE A 171
VAL A 114
ILE A 116
 None
 1.46A 4dqbA-3eefA:
undetectable		 4dqbA-3eefA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 ASP A  50
SER A  51
ASN A  49
GLY A  98
 ZN  A 183 (-2.6A)
None
None
None
 0.99A 4fo4A-3eefA:
undetectable		 4fo4A-3eefA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 GLY A  95
ASP A   9
HIS A  91
ASN A  49
LEU A 101
 None
 1.26A 4pooA-3eefA:
4.3		 4pooA-3eefA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_A_URFA302_1
(URIDINE
PHOSPHORYLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 THR A  27
GLY A  29
ALA A  31
ILE A  79
 None
 0.72A 4txnA-3eefA:
undetectable		 4txnA-3eefA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 THR A  27
GLY A  29
ALA A  31
ILE A  79
 None
 0.73A 4txnB-3eefA:
undetectable		 4txnB-3eefA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_C_URFC302_1
(URIDINE
PHOSPHORYLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 THR A  27
GLY A  29
ALA A  31
ILE A  79
 None
 0.71A 4txnC-3eefA:
undetectable		 4txnC-3eefA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_D_URFD302_1
(URIDINE
PHOSPHORYLASE)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 7 THR A  27
GLY A  29
ALA A  31
ILE A  79
 None
 0.73A 4txnD-3eefA:
undetectable		 4txnD-3eefA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 SER A  41
GLY A  42
ILE A 110
ALA A   4
LEU A   5
 None
 1.20A 5zjiA-3eefA:
undetectable
5zjiJ-3eefA:
undetectable		 5zjiA-3eefA:
19.23
5zjiJ-3eefA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		3 / 3 LYS A  90
VAL A  48
ASP A  50
 None
None
ZN  A 183 (-2.6A)
 0.63A 6fgdA-3eefA:
2.3		 6fgdA-3eefA:
20.10