SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eeq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 11 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 1.00A 1hxwB-3eeqA:
undetectable		 1hxwB-3eeqA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.96A 1t3rA-3eeqA:
undetectable		 1t3rA-3eeqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.97A 1t7iA-3eeqA:
undetectable		 1t7iA-3eeqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		4 / 7 LEU A 316
THR A 328
ALA A 330
SER A 217
 None
SO4  A   3 (-3.1A)
None
None
 0.79A 1tyrB-3eeqA:
undetectable		 1tyrB-3eeqA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		4 / 8 LEU A 117
ILE A  33
ILE A  17
ILE A  19
 None
 0.80A 2bu8A-3eeqA:
undetectable		 2bu8A-3eeqA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 11 GLY A 219
ILE A 218
SER A 217
ILE A 216
LEU A 242
 None
 0.95A 2kawA-3eeqA:
undetectable		 2kawA-3eeqA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 ILE A  90
ALA A  73
ILE A  33
LEU A 117
THR A  74
 None
 1.17A 2w3aB-3eeqA:
undetectable		 2w3aB-3eeqA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKK_E_MFXE1100_1
(TOPOISOMERASE IV
DNA)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		3 / 3 ARG A  48
GLU A  35
SER A  23
 SO4  A   5 (-4.9A)
None
None
 0.69A 2xkkA-3eeqA:
2.4
2xkkC-3eeqA:
2.2		 2xkkA-3eeqA:
18.91
2xkkC-3eeqA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		3 / 3 SER A 222
GLU A 229
ASP A 225
 None
 0.79A 3bwmA-3eeqA:
3.7		 3bwmA-3eeqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 9 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.94A 3ektA-3eeqA:
undetectable		 3ektA-3eeqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 SER A 217
THR A 333
GLY A 311
LEU A 307
VAL A 273
 None
 1.21A 3fzgA-3eeqA:
undetectable		 3fzgA-3eeqA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_2
(PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 9 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.96A 3gguB-3eeqA:
undetectable		 3gguB-3eeqA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.96A 3lzvA-3eeqA:
undetectable		 3lzvA-3eeqA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 GLY A 250
ILE A 251
VAL A 238
ALA A 332
ILE A 249
 None
 1.06A 3n3iA-3eeqA:
undetectable		 3n3iA-3eeqA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.96A 3oy4B-3eeqA:
undetectable		 3oy4B-3eeqA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 9 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.86A 3u7sA-3eeqA:
undetectable		 3u7sA-3eeqA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		6 / 12 GLY A 234
ILE A 231
ILE A 329
LEU A 239
VAL A 238
ILE A 321
 None
 1.49A 4azvA-3eeqA:
3.1		 4azvA-3eeqA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.97A 4dqbB-3eeqA:
undetectable		 4dqbB-3eeqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 9 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.96A 4dqcB-3eeqA:
undetectable		 4dqcB-3eeqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.94A 4dqeB-3eeqA:
undetectable		 4dqeB-3eeqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.96A 4dqhB-3eeqA:
undetectable		 4dqhB-3eeqA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		4 / 6 PHE A 266
GLY A 234
LEU A 239
VAL A 238
 None
 0.82A 4dubA-3eeqA:
undetectable		 4dubA-3eeqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		4 / 6 PHE A 266
GLY A 234
LEU A 239
VAL A 238
 None
 0.86A 4dubB-3eeqA:
undetectable		 4dubB-3eeqA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 10 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.89A 4njtB-3eeqA:
undetectable		 4njtB-3eeqA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 ILE A 231
ILE A 235
GLY A 219
ALA A 330
VAL A 238
 None
 1.12A 4nkvA-3eeqA:
undetectable		 4nkvA-3eeqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 ILE A 231
ILE A 235
GLY A 219
ALA A 330
VAL A 238
 None
 1.12A 4nkvC-3eeqA:
undetectable		 4nkvC-3eeqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 ILE A 231
ILE A 235
GLY A 219
ALA A 330
VAL A 238
 None
 1.09A 4nkvD-3eeqA:
undetectable		 4nkvD-3eeqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 9 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.94A 4q1wA-3eeqA:
undetectable		 4q1wA-3eeqA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		3 / 3 SER A 222
GLU A 229
ASP A 225
 None
 0.80A 4xudA-3eeqA:
3.6		 4xudA-3eeqA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		4 / 7 LYS A 136
GLY A 109
ASN A 111
HIS A 107
 None
None
SO4  A   2 (-3.9A)
None
 1.24A 5a5zC-3eeqA:
undetectable		 5a5zC-3eeqA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		3 / 3 ASP A 233
ARG A 232
TYR A 236
 None
 1.04A 5a7mB-3eeqA:
3.3		 5a7mB-3eeqA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 ILE A 235
GLY A 234
ASP A 233
ARG A 256
ALA A 302
 None
None
None
None
SO4  A   3 (-3.8A)
 1.10A 5h5fA-3eeqA:
2.1		 5h5fA-3eeqA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 9 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.95A 5kr0B-3eeqA:
undetectable		 5kr0B-3eeqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 ALA A 330
LEU A 316
ILE A 317
SER A 217
GLY A  16
 None
 1.08A 5m24A-3eeqA:
undetectable		 5m24A-3eeqA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 LEU A 318
GLY A 219
ALA A 306
GLY A 250
ILE A 249
 None
 0.86A 5t2zB-3eeqA:
undetectable		 5t2zB-3eeqA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 SER A 254
VAL A 301
ALA A 330
ALA A 302
GLY A 219
 None
SO4  A   3 (-4.0A)
None
SO4  A   3 (-3.8A)
None
 1.21A 5tzoA-3eeqA:
undetectable		 5tzoA-3eeqA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		5 / 12 SER A 254
VAL A 301
ALA A 330
ALA A 302
GLY A 219
 None
SO4  A   3 (-4.0A)
None
SO4  A   3 (-3.8A)
None
 1.20A 5tzoC-3eeqA:
undetectable		 5tzoC-3eeqA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 3eeq PUTATIVE COBALAMIN
BIOSYNTHESIS PROTEIN
G HOMOLOG
(Sulfolobus
solfataricus) 		4 / 5 VAL A 157
LYS A 158
ASN A 160
PRO A 153
 None
 1.42A 6fi4A-3eeqA:
undetectable
6fi4B-3eeqA:
undetectable		 6fi4A-3eeqA:
23.24
6fi4B-3eeqA:
10.53