SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3eez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 8 GLY A  64
GLY A  62
TYR A 100
VAL A  36
 None
 0.84A 1dbbH-3eezA:
undetectable
1dbbL-3eezA:
undetectable		 1dbbH-3eezA:
18.62
1dbbL-3eezA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		3 / 3 TRP A 198
HIS A 234
MET A 207
 None
 0.86A 1l5qB-3eezA:
2.2		 1l5qB-3eezA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		3 / 3 TYR A 154
ARG A 337
GLN A 323
 None
 0.97A 1tw4A-3eezA:
undetectable		 1tw4A-3eezA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		3 / 3 TYR A 159
ARG A 337
GLN A 323
 None
 0.88A 1tw4A-3eezA:
undetectable		 1tw4A-3eezA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		3 / 3 SER A 297
ASP A 324
ASP A 329
 None
 0.64A 2plwA-3eezA:
2.8		 2plwA-3eezA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 7 ILE A  69
PRO A 355
GLY A  46
TRP A  47
 None
 1.19A 2pnjB-3eezA:
4.3		 2pnjB-3eezA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 7 LEU A  31
ASP A  32
ILE A  65
ARG A  66
 None
 0.99A 2qqdA-3eezA:
undetectable
2qqdE-3eezA:
0.7		 2qqdA-3eezA:
10.51
2qqdE-3eezA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		3 / 3 GLU A  16
GLN A 323
ARG A 337
 None
 1.00A 2w3bB-3eezA:
undetectable		 2w3bB-3eezA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		3 / 3 TRP A  53
VAL A 150
ARG A 148
 None
 0.91A 3b0wA-3eezA:
undetectable		 3b0wA-3eezA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 4 LEU A  13
PRO A  14
LEU A 326
ARG A 337
 None
 1.27A 3hcoA-3eezA:
4.1		 3hcoA-3eezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		5 / 12 VAL A 269
GLY A 270
LEU A  99
ARG A 277
ILE A 311
 None
 1.02A 3ijdB-3eezA:
7.4		 3ijdB-3eezA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		5 / 10 ALA A  33
LEU A 360
GLU A  49
LEU A 299
THR A  51
 None
 1.19A 3jw5B-3eezA:
undetectable		 3jw5B-3eezA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		5 / 11 VAL A 194
ILE A 174
ALA A 203
ALA A 236
ALA A 209
 None
 1.03A 3mdtB-3eezA:
undetectable		 3mdtB-3eezA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_B_ACTB601_0
(CHOLINE OXIDASE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 5 TRP A 198
ILE A 230
HIS A 234
VAL A 238
 None
 1.10A 3nneB-3eezA:
0.0		 3nneB-3eezA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_D_ACTD601_0
(CHOLINE OXIDASE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 5 TRP A 198
ILE A 230
HIS A 234
VAL A 238
 None
 1.17A 3nneD-3eezA:
0.0		 3nneD-3eezA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_F_ACTF601_0
(CHOLINE OXIDASE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 4 TRP A 198
ILE A 230
HIS A 234
VAL A 238
 None
 1.10A 3nneF-3eezA:
0.6		 3nneF-3eezA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 6 ALA A 203
ILE A 230
HIS A 234
VAL A 238
 None
 1.21A 3nneG-3eezA:
undetectable		 3nneG-3eezA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		5 / 12 GLY A 350
GLY A 352
GLU A 347
ALA A 117
LEU A 124
 None
 1.12A 3vywA-3eezA:
3.2		 3vywA-3eezA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		3 / 3 ASP A  41
ARG A  82
LYS A   1
 None
 1.13A 3wipG-3eezA:
undetectable		 3wipG-3eezA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 6 LEU A  35
LYS A  37
LEU A 360
GLU A 357
 None
 1.17A 4f3tA-3eezA:
undetectable		 4f3tA-3eezA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		4 / 5 GLY A 197
ARG A 196
GLY A 221
GLU A 222
 None
 1.02A 4z2eB-3eezA:
undetectable
4z2eC-3eezA:
undetectable		 4z2eB-3eezA:
22.09
4z2eC-3eezA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		6 / 12 ASP A 241
ARG A 268
LEU A  84
ILE A 105
ALA A 108
ALA A 300
 None
 1.39A 5vc0A-3eezA:
undetectable		 5vc0A-3eezA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		5 / 12 ARG A 133
GLY A 263
PHE A 290
ALA A 254
ASP A 313
 None
 1.14A 5x66A-3eezA:
undetectable
5x66B-3eezA:
undetectable		 5x66A-3eezA:
21.99
5x66B-3eezA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Ruegeria
pomeroyi) 		5 / 11 SER A 103
VAL A 291
GLY A 263
SER A 239
ALA A 259
 None
 1.36A 6hu9A-3eezA:
undetectable
6hu9E-3eezA:
undetectable
6hu9I-3eezA:
undetectable		 6hu9A-3eezA:
19.51
6hu9E-3eezA:
20.38
6hu9I-3eezA:
8.89